6R0X


Conserved Protein Domain Family
G6B
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pfam15096: G6B (This model is not part of the current CDD release)
G6b-B extracellular V-set Ig-like domain
G6b-B is a unique platelet ITIM-containing receptor that is highly expressed in mature megakaryocytes and platelets. t is a type I transmembrane protein that consists of a single N-glycosylated immunoglobulin-variable (IgV)-like domain in its extracellular region, a single transmembrane domain and a cytoplasmic tail containing an ITIM and an immunoreceptor tyrosine-based switch motif (ITSM). The extracellular matrix heparan sulfate (HS) proteoglycan perlecan was identified as a G6b-B binding partner. Subsequent in vitro biochemical studies and a cell-based genetic screen demonstrated that the interaction is specifically mediated by the HS chains of perlecan. This entry represents the N-terminal extracellular HS binding domain.
Links
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Statistics
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PSSM-Id: 521651
Aligned: 9 rows
Threshold Bit Score: 220.159
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6R0X_E         1 NPGASLDGRPGDRVDLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWAAAAGAPTVPPLQPFVGRLRSLDS-GIRRLEL 79  human
2_pfamImport   1 DPGVSLDGRPGDRVNLSCVGVSQPIRWVWAPSFPACKGLPKGRRRILWASSSGTPTVSPAQPFAGRLRVLDHpGIRRLEL 80 
4_pfamImport   1 DPGASLNGHPGDRVNLSCIGVSQPTRWVWAPRFPACKGLSKGRRPILWASPSGTPTVSPAQPFAGRINALDL-GIRRLEL 79 
3_pfamImport   1 GALPFLEGRPGDRVNLSCVGVSHPIRWAWAPSFPACKGLSKGRRPILWASSSGTPTTPPAHPFAGRLRALDP-GIQRLEL 79 
XP_004043747  18 NPGASLDGRPGDRVNLSCVGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDS-GIRRLEL 96 
Q6MG59        18 NPEVSLEGNPGDRVNLSCIGVSDPTRWAWAPSFPACKGLSKGRRPILWASSSGTPTV--LQHFSGRLRSLDT-GIKRLEL 94  Norway rat
XP_014445579  18 DPGASLHGHPGDRVNLSCIGVSHPVRWAWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFAGRLRSLDS-GIRRLEL 96 
Q0P5G6        19 DPGASLNGHPGDRVNLSCIGVSQPTRWVWAPRFPACKGLSKGRRPILWASPSGTPTVPPAQPFAGRINALDL-GIRRLEL 97  cattle
XP_036731471  38 NPGASLDGSPGDRVNLSCAGVSHPIRWAWAPSFPACKGLSKGRRPILWASSSGTPTVPPVQPFAARLRALDP-GIRRLEL 116 Chinese pangolin

6R0X_E        80 LLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKA 114 human
2_pfamImport  81 LLSAGDSGTFICRGRQEDESHTVLHVLGDAADCRG 115
4_pfamImport  80 LLSAGDSGTFICKGRQEEESRTELHVLGDRAYCKA 114
3_pfamImport  80 LLNEGDSGTFFCKGRQDEESRTLLHVLEDGADCRP 114
XP_004043747  97 LLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKA 131
Q6MG59        95 LLSAGDSGTFFCKGRQENESRTVIQVLGDKAGCRP 129 Norway rat
XP_014445579  97 LLSPGDSGTFICRGRHEDESRTVLHVLGDRADCKA 131
Q0P5G6        98 LLSAGDSGTFICKGRQEEESRTELHVLGDRAYCKA 132 cattle
XP_036731471 117 LLSAGDSGTFFCRGRHEDESRTVLHVLGDRADCRA 151 Chinese pangolin
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