8Q5R


Conserved Protein Domain Family
IL33_bt
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pfam15095: IL33_bt (This model is not part of the current CDD release)
Interleukin 33
This entry represents a beta-trefoil related domain found in interleukin-33 (IL33), which that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. It also serves as a warning signal between cells at times of injury or cell death.
Links
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Statistics
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PSSM-Id: 521650
Aligned: 10 rows
Threshold Bit Score: 265.934
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8Q5R_A         3 QGTSLLTQS-PASLSTYNDQSVSFVLENGCYVINVDDSGKDQEQDQVLLRYYESPCPASQSGDGVDGKKVMVNMSPIKDT 81  house mouse
1_pfamImport   1 LGVTGYREYrSVSLSTYDNQSITFVVGDEGYYINVDDLGTEGEKDKVLFHLYDSQLAASGTGDDVDGHKVMVRMSPANNK 80 
XP_006939218 111 TDVPSIQEY-SASLSTYNDQSITFVFEDGSYEIYVEDLGKDQEKDKVLFRYYDFQSPSRETGDADDGHTLLVNLSPTKDK 189
XP_038536832 106 ANVPSIQEY-SASLSTYNDQSITFVFEDGSYEIYVEDLRKGQEKDKVLFRYYDSQSPSHETGDDVDGQTLLVNLSPTKDK 184
Q08DU3       113 TGLPSIKEH-SASLSTYNDQFITFVLEDGSYEIYVEDLIDNQEKDKVLLRYYDSQFPSSETDDGGSHRKLMVNLSPTKDK 191 cattle
XP_005660169 116 TNLLSIKEH-SASLSTYNDQYITFAFEDGSYEIYVEDLRKDQEKDKVLLRYYDSQIPSSETDGGGDHRKLMVNLSPTKDK 194
O95760       114 TGISPITEY-LASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTK-- 190 human
Q8BVZ5       111 QGTSLLTQS-PASLSTYNDQSVSFVLENGCYVINVDDSGKDQEQDQVLLRYYESPCPASQSGDGVDGKKLMVNMSPIKDT 189 house mouse
EHB01975     116 IGISLISES-CASLSTYNDQSVSFVLEDGSYVINVEDLGKDQEKDKVLLRYYESQYPSNESGDGVDGKLLMVNLSPTKDT 194
XP_004782024 110 TNFPSIQEH-SASLSTYNDQSITFVFEDGGYEIYVEDLRKDQEKDKVLFRYYDSQSPTHGTGDGVDGQTLLVNLSPTKDK 188

8Q5R_A        82 DIWLHAndKDYSVELQRGDVSPPEQAFFVLHKK--SSDFVSFECKNLPGTYIGVKDNQLALVEEKDE-----SCNNIMFK 154 house mouse
1_pfamImport  81 DFLLHA--EEHSVKVQKYENSLPDQTLFLLHKElgPSKCVSFECNSKPGVYLGVEGNHLALIEPNDQta-hlRRKNIIFK 157
XP_006939218 190 DFLLHAnnKEHSVELQKCKKPLPDQAFFRLHRK--SSKCVSFECKNDPGVFIGVKDNHLALIKVEDQte-yfSTENIIFK 266
XP_038536832 185 DFLLHAnnEEHSVELQKCENQLPDQAFFLLHRK--SSECVSFECKNNPGVFIGVKDNHLALIKVGDQtk-dsYIEKTIFK 261
Q08DU3       192 DFLLHAnsKEHSVELQKCENQLPEQTFFVLHET--SSQCVSFECKSNPGVFLGVKDNQLALIKRGEHpe-dsNSQNITFK 268 cattle
XP_005660169 195 DFLLHAnsKEHSVELQKCENPLPEQAFFVLHEQ--PSKCVSFECKSHPGVFLGVKNNQLALIKLGEHpe-dsNRENTTFK 271
O95760       191 DFWLHAnnKEHSVELHKCEKPLPDQAFFVLHNM--HSNCVSFECKTDPGVFIGVKDNHLALIKV-DSse-nlCTENILFK 266 human
Q8BVZ5       190 DIWLHAndKDYSVELQRGDVSPPEQAFFVLHKK--SSDFVSFECKNLPGTYIGVKDNQLALVEEKDE-----SCNNIMFK 262 house mouse
EHB01975     195 DFSLHAnkKEHSVELQKCETTLPDQAFFVLHKE--SSEFVSFECKSNRGTYIGVKDNQLALIEGKNP-----SSENIMFK 267
XP_004782024 189 DFLLHAnnKEHSVELQKCENQLPDQAFFRLHRK--SSKCVSFECKNNPGVFIGVKDNHLALIKVGDPtedskSIENTIFK 266

8Q5R_A       155 LS 156 house mouse
1_pfamImport 158 LS 159
XP_006939218 267 LS 268
XP_038536832 262 LS 263
Q08DU3       269 LS 270 cattle
XP_005660169 272 LS 273
O95760       267 LS 268 human
Q8BVZ5       263 LS 264 house mouse
EHB01975     268 LS 269
XP_004782024 267 LS 268
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