2KLL,5VI4


Conserved Protein Domain Family
IL33_bt
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pfam15095: IL33_bt (This model is not part of the current CDD release)
Interleukin 33
This entry represents a beta-trefoil related domain found in interleukin-33 (IL33), which that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. It also serves as a warning signal between cells at times of injury or cell death.
Links
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Statistics
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PSSM-Id: 494821
Aligned: 9 rows
Threshold Bit Score: 264.019
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2KLL_A         5 TGISPITEY-LASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTK-- 81  human
1_pfamImport   1 LGVTGYREYrSVSLSTYDNQSITFVVGDEGYYINVDDLGTEGEKDKVLFHLYDSQLAASGTGDDVDGHKVMVRMSPANnk 80 
XP_006939218 111 TDVPSIQEY-SASLSTYNDQSITFVFEDGSYEIYVEDLGKDQEKDKVLFRYYDFQSPSRETGDADDGHTLLVNLSPTKdk 189
XP_038536832 106 ANVPSIQEY-SASLSTYNDQSITFVFEDGSYEIYVEDLRKGQEKDKVLFRYYDSQSPSHETGDDVDGQTLLVNLSPTKdk 184
Q08DU3       113 TGLPSIKEH-SASLSTYNDQFITFVLEDGSYEIYVEDLIDNQEKDKVLLRYYDSQFPSSETDDGGSHRKLMVNLSPTKdk 191 cattle
2_pfamImport   1 TNLLSIKEH-SASLSTYNDQYITFAFEDGSYEIYVEDLRKDQEKDKVLLRYYDSQIPSSETDGGGDHRKLMVNLSPTKdk 79 
XP_004782024 110 TNFPSIQEH-SASLSTYNDQSITFVFEDGGYEIYVEDLRKDQEKDKVLFRYYDSQSPTHGTGDGVDGQTLLVNLSPTKdk 188
5VI4_A         3 QGTSLLTQS-PASLSTYNDQSVSFVLENGSYVINVDDSGKDQEQDQVLLRYYESPSPASQSGDGVDGKKLMVNMSPIKdt 81  house mouse
EHB01975     116 IGISLISES-CASLSTYNDQSVSFVLEDGSYVINVEDLGKDQEKDKVLLRYYESQYPSNESGDGVDGKLLMVNLSPTKdt 194

2KLL_A        82 DFWLHAnnKEHSVELHKCEKPLPDQAFFVLHNM--HSNCVSFECKTDPGVFIGVKDNHLALIKV-DSSENL-CTENILFK 157 human
1_pfamImport  81 DFLLHA--EEHSVKVQKYENSLPDQTLFLLHKElgPSKCVSFECNSKPGVYLGVEGNHLALIEPnDQTAHL-RRKNIIFK 157
XP_006939218 190 DFLLHAnnKEHSVELQKCKKPLPDQAFFRLHRK--SSKCVSFECKNDPGVFIGVKDNHLALIKVeDQTEYF-STENIIFK 266
XP_038536832 185 DFLLHAnnEEHSVELQKCENQLPDQAFFLLHRK--SSECVSFECKNNPGVFIGVKDNHLALIKVgDQTKDS-YIEKTIFK 261
Q08DU3       192 DFLLHAnsKEHSVELQKCENQLPEQTFFVLHET--SSQCVSFECKSNPGVFLGVKDNQLALIKRgEHPEDS-NSQNITFK 268 cattle
2_pfamImport  80 DFLLHAnsKEHSVELQKCENPLPEQAFFVLHEQ--PSKCVSFECKSHPGVFLGVKNNQLALIKLgEHPEDS-NRENTTFK 156
XP_004782024 189 DFLLHAnnKEHSVELQKCENQLPDQAFFRLHRK--SSKCVSFECKNNPGVFIGVKDNHLALIKVgDPTEDSkSIENTIFK 266
5VI4_A        82 DIWLHAndKDYSVELQRGDVSPPEQAFFVLHKK--SSDFVSFESKNLPGTYIGVKDNQLALVEEkDE-----SSNNIMFK 154 house mouse
EHB01975     195 DFSLHAnkKEHSVELQKCETTLPDQAFFVLHKE--SSEFVSFECKSNRGTYIGVKDNQLALIEGkNP-----SSENIMFK 267

2KLL_A       158 LS 159 human
1_pfamImport 158 LS 159
XP_006939218 267 LS 268
XP_038536832 262 LS 263
Q08DU3       269 LS 270 cattle
2_pfamImport 157 LS 158
XP_004782024 267 LS 268
5VI4_A       155 LS 156 house mouse
EHB01975     268 LS 269
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