Conserved Protein Domain Family
SPMIP4-like
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pfam15093: SPMIP4-like (This model is not part of the current CDD release)
Sperm-associated microtubule inner protein 4
This family (previously DUF4555) includes the homologs of human sperm-associated microtubule inner protein 4 (SPMIP4) that is found predominantly in testis. SPMIP4 is a microtubule inner protein (MIP) part of the axonemal dynein-decorated doublet microtubules (DMTs). Members of this family adopt rather extended conformation and contain a single or multiple Mn motifs. Each Mn motif consists of a 5- to 6-residue helix flanked by a Tyr/Phe residue on one end and by a Ser/Thr on the other that binds the shoulder of the alpha-tubulin S9/S10 loop. Members of this family are likely to stabilise the microtubule structure in the sperm flagella.
Links
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Statistics
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PSSM-Id: 521649
Aligned: 7 rows
Threshold Bit Score: 412.666
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003467976   1 MKLINRRP-YCCKELEGADILSDTLYSNEVHTPLLTTTRPTASGDRYqELRESL-PQCRLPWGAEREYGGIIPVALPEEH 78 
XP_003788562   1 MEVIQGRP-YCCRELEGSDILSDTFYSNELHTPLQTTTRSTASHARY-ELRDTV-RECRLPWGAGKEYGGIMPISLPEEY 77 
2_pfamImport   1 MEVIHGRS-CCCSELEGDD-LSDTFCSQEVHTPLQTPARPTASDDRYqELRESF-QQRRLSWGADREYCGMTPTSLPAEH 77 
XP_002109610   1 MDYTANRMrELYKETIAVPVLSPTYQSNQIFTPLQSPQRETVSESQYrTYYEKWgRATKTPWGRHHSYAGIGPLFLPPGH 80 
XP_010711092   1 MMILHDLL-RYHRETGGKTILSRTFESNEVLTPLQIPSPPTVLQDRYeEFRESL-HHCKLPGGTEREHGGIVLPVLSKDQ 78 
3_pfamImport   1 MM--HDQP-RYHREIKGTESLSRTFESNEILTPLQIPSRLTVSQDRYkKFRESL-HCCKLPGGIQSVHGGTALPVLPEDQ 76 
XP_007508010   1 MEALHDLP-DYYRQQEGTDILSRTLISDGVHTPLQIPARPTSSEDRYrELKQTF-SAYRLPWGLEREYGGTMPLSMPEDY 78  gray short-tail...

XP_003467976  79 RPKCEPPCVMGKGHQHYGFGGEICS----------------RKLPIEQFYYLTQNKKSDVYGNDSLLPKPPNSAVEEICL 142
XP_003788562  78 RLKFDPPYAMGKGHLHFGFGGDTYP----------------RKLSMEQFYHLTQNRKSDIYGNDSLLPKPPSSAIGETCL 141
2_pfamImport  78 RPKSEPPRVMGKGHQHYGFGGETWQ----------------RKLPVEQFYYLTQNKGSDIYGNDSLSPKPPNPTVEEICC 141
XP_002109610  81 RPKEEPPTRVEKGHKHYGSGIIPFPtlyedsekfmlflmiyDSTPVQQNYCRTGSQLSRLRKTDELVPKPLTADLVNIQV 160
XP_010711092  79 K----SPCAHVRGHPHFGSNVFPWP----------------RGLPIEQYYDVTLLKKSDVRMNDDLLCKPPSSLAKPLSL 138
3_pfamImport  77 RAKAKSPCTVVRGHYHFGSAVDPCP----------------RGLPIEQYYDVTLLKKSDVRMNDDLLHKPPSSLAKPLCL 140
XP_007508010  79 RPKSEPPRYLTKGHRHYGFGGDPWP----------------RGIPIRQFYHLTQNKKSNLYDNDSLlpkppcmeakPLPM 142 gray short-tail...

XP_003467976 143 --PYPVEHPYHTHTPRGAMFPTFTFPKELYSRYKPRTH-----RPFPPTVPTKTYDTTVL-KTRGNPYRYELL---DFPM 211
XP_003788562 142 --PYPIEHPYHTHIPRTSMFPTFTSPKDLYTGIKARTQ-----QPFPPTVPTKPYDTTVL-KIKGHPYRYELI---DIPT 210
2_pfamImport 142 --PYLVEHPHNTHISGCAKFPTFTSPKELYAGIKARSQ-----QPFPPTVPTKAYDTTIL-KARGNPYRHELV---DFPS 210
XP_002109610 161 khPLPREHPYASHISKLSIFPSPVSPDEANGRLAVASTpyggpPPVPSTIATQPSEQIIRgKTKGSPWRHEIVqngEHPL 240
XP_010711092 139 --PFPTSHPYQTHISKYAMFPDFRSPEDRDTGTDASSC-----QSFHSNISCKAFDMVVLrNTRGNPYRHEVV---SIPF 208
3_pfamImport 141 --PFPISHPYQTHISRYAMFPNFRSPEDRDTGIDASNH-----QPFHPNIPSKPYDVVVLrKTKGNPYRHEVV---SIPP 210
XP_007508010 143 --GFPIAHPYQTHISRCALFPTFTSPLDVCKGLDASLQ-----QPFPATVPTMPYETTVLkKSKGNSYRHEHL---YFPS 212 gray short-tail...

XP_003467976 212 DSKKRALSWPGQDVYYNFPKCVEKNKPLFYPKPPKTFAPNTCLNSLDATNYAKEANIQRNLERSQWISSYNH 283
XP_003788562 211 DSKKKALTWPGQGVYYDFPKCVEKNKPIFYPKPPKTFAPNTSLNSWDPINSAKEANIQRNLERSHWLTSYTR 282
2_pfamImport 211 DSKKKTSTWPGQGVYYNFPKCVEKNKPVFYPKPPKSFAPNTSLNSWDPINSLKEANIQRNLERSHWITSYTH 282
XP_002109610 241 --HRKALTWHGESVYQIYSGPNTPVRQQIYPAPPKSIAPNPRPRDGNLAISPRTADTLIDVRKSLMTTTYQS 310
XP_010711092 209 DSLKEALCCSRQHACLQLPKFSEEKDQIYYPNPSKIVAPNSTFRELEHKVSSRTSNILQNIERAQWITTYNR 280
3_pfamImport 211 DSLKKALHWPGQYTYFQLPKFAEEKGQIYYPNPPKMVAPNSTFKELEHNLSPRTTNMLRNTERAQGITTYSR 282
XP_007508010 213 DSQKKALRWPGQELYYDIPKFDLKNTQIYYPKPPKLVAPNTTSMTLDPLHCKQEANIKRNLERSHWITSYTH 284 gray short-tailed opossum
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