Conserved Protein Domain Family
FAM101
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pfam15068: FAM101 (This model is not part of the current CDD release)
FAM101 family
This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilise peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localisation and shape in the nucleus plays a role in cellular and developmental processes.
Links
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Statistics
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PSSM-Id: 521638
Aligned: 17 rows
Threshold Bit Score: 236.937
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006640307   1 MVGHLHL-QAMD-----EsLKGKTREGLLDSPDSGLPPSPSPPFYSLsPAILESRAGGSTTPMEQQGFSyRKESKEGKL- 73 
XP_005988985   1 MVGHLHL-QGMD-----EsLKGKNREGLLDSPDSGLPPSPSPPFYSLsSGILEGRAGGSTTPIEPLGHSsRKEAREGKL- 73 
NP_001008059   1 MVGRLNL-QDVPdl--lD-MKK-KGERVLDSPDSGLPPSPCPSNW-----HLSAGTAEKSPEQDISGQNaPANLALS--- 67 
3_pfamImport   1 MVGRLSK-QDVPel--vD-AKK-KGSGPLD-----------PHSWRLrTVTLAWGWGARECVCVCGGASpGSGPALTAFs 64 
1_pfamImport   1 MVGRLSL-QDVPel--vD-TKK-KGDGVLDSPDSGLPPSPSPGHWGL---AAAGGGGERSAAPGTLEPDaAASPANP--- 69 
Q6AXS9         1 MVGRLSL-QDVPel--vD-TKK-KGDGVLDSPDSGLPPSPSPSHWGL--AAATGGGGERAPVAGTLEPDaTVTSVVP--- 70  Norway rat
6_pfamImport   1 MVGRLSL-QDVPel--vD-TKK-KGDGVLDSSDSGLLSSSS--HWGD--GAAAPGSGSDHECKHVSSFQpFAKPQQSLq- 70 
XP_006641101   1 MVGRLNL-QHVSdddplN-MRR-KAEKVLDSPDSGLPPSPGPSAW-----LPSPVSGDR------GVCGgIAEAETRKEp 66 
XP_003441619   1 MVGSLNL-PNLCegdplD-MSC-RAERGLDSPDSGLPPSPSPSAW-----LL-PVSADKA-----GGVSsVSEDEGR--- 63 
4_pfamImport   1 MVGRLNLqPNACegdplD-MSC-RAERGLDSPDSGLPPSPSPSAW-----LLQPVCAYKP-----GGVSpVSEDEGR--- 65 

XP_006640307  74 ----LPYLLLNSSGTEMKSRMYPVFFGESIEVCPKPKREVRCNSEVKYDSDKHYRDNVYCAPVP-TVTSYSETVIAAPNC 148
XP_005988985  74 ----LPYLLLNSAASDPRPKMHPIFFGESIEVKPEPSQEIRCNSEIKYDSEKHYRDHVYYAPIP-TVTAYSETVIAAPNC 148
NP_001008059  68 ----------LSLSSSFTPRLCPLSFGEGVEFDPLPPKEIRYTSSVKYDSEKHFIDNIYM-PMGlGLSSCSQSVICVPNC 136
3_pfamImport  65 lswkTPASVPSALAAGCSPRLCPLSFGEGVEFDPLPPKEVRYTSSVKYDSERHFIDDVQL-PLGlAVASCSQTVTCVPNC 143
1_pfamImport  70 ------APLPSPLAFACSPRLCPLSFGEGVEFDPLPPTEVRYTSSVKYDSERHFIDDVHL-PLGlAVASCSYTVTCLPNC 142
Q6AXS9        71 ----NPASLSHSLAGICSPRLCPLSFGEGVEFDPLPPKEIKYTSSVKYDSERHFIDDVQM-PLGlVVASCSQTVTCIPNC 145 Norway rat
6_pfamImport  71 ----NPASLPAPLASGCLPRLCPLSFGEGVEFDPLPPTEVRYTSSVKYDSERHFINDVHM-PLGlAVASCSQTVTCVPNC 145
XP_006641101  67 ---------aPPVPSSSVPRLHLLSYGEGVLVDPLPPKEIRYKSSVRYESDSHYIHHVSLRPVGlGVSSCSQTVMVLPDR 137
XP_003441619  64 ------GSLVPALPAGSFPQLHPLSFGEGIALDPLPPKEMRYTSSVHYDSDRHFIQNVSLEPWGqSLEHCRQTVMAVSNS 137
4_pfamImport  66 ------GSLVPVLPCGSLQQLQPLSYGEGIALDPLPSKEIRFTSSVHYDSDRHFIQGVALRPVGqGLEHCRQTVVAVPHS 139

XP_006640307 149 TWRNYKTELQFEPRQKPLRFQSTTIIFPKHAKNIYRTTLNYNGSSADRWFVSRVQLESS 207
XP_005988985 149 TWRNYKSELIFEPKQKPLRFQTTTIIFPKHAKNIYRTTLSYNSRNAKRWFMSSVQLEST 207
NP_001008059 137 TWRNYRAEVHLEPKNKPQRFKSTTIVYPKHTKVIYTTTLDYNCKKCMRRFLSSVELESA 195
3_pfamImport 144 TWRSYKAEVRFEPRHKPARFLSTTIVYPKYPKTVYTTTLDYNCRKKLRRFLSSVELEAM 202
1_pfamImport 143 TWRNYKAEVHFKPCHKPTRFLSTTIVYPKYPKTVYTTTLDYNCRKTLRRFLSSVELEAT 201
Q6AXS9       146 TWRNYKAEVRFEPRHKPARFLSTTIIYPKYPKTVYTTTLDYNCHKKLRRFLSSVELEAT 204 Norway rat
6_pfamImport 146 TWRNYRAEVRFEPRHRPARFLSTTIVYPKYPKTVYTTTLGYNCRKTLRRFLSSVELEAP 204
XP_006641101 138 TWRRYKTQLEFQPRQRALRYQSTTIVYPKRTRAVYTTRLQYDCPRLARRFLAKVEMEAS 196
XP_003441619 138 TWRHYVTQLEFHPRHRPKQFKSTTIIYPKKASTIYTTELSYNCHRLSRRFLSSVELDAV 196
4_pfamImport 140 TWRHYKTQLDFQPRHRPQCFKSTTIVYPKKTSALYATELSYDCRRLSKRFTSSVEME-- 196
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