Conserved Protein Domain Family
FAM124

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pfam15067: FAM124 (This model is not part of the current CDD release)
FAM124 domain
The FAM124 domain belongs to the Vicinial Oxygen Chelatase (VOC) superfamily of proteins and is comprised of two tandem alpha/beta domains. Residue conservation suggests that it might be enzymatic. Certain FAM124 domains fused to the TRADD-N domain are predicted to have secondarily lost their enzymatic activity and might be involved in protein-protein interactions.
Statistics
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PSSM-Id: 521637
Aligned: 23 rows
Threshold Bit Score: 223.714
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002111349  50 CIIHCEFENGLKKKMERLYRPMLDYINSTRQCISIEDDSK--------------RSFNRSRnSSSSSEDinqfdv----- 110
8_pfamImport   1 VSVHIITDPGNAKALQKAADSVLAWIHPELQLFRVSERGAwrrpkrprpgggagQ-------------P----------- 56 
XP_040057281  10 VCVHLIVDPGQGKLLQRAADGVLAWVHPELQLLRVSERASfsgpks---rqnagQ-------------P----------- 62 
7_pfamImport   1 VSVHLIADPGEGRILQRAADSILACVHPDLQLFRVSQRQSaelg-------parQ-------------P----------- 49 
2_pfamImport   1 --MHIIANPGESALLQQAIDNLLTWIHPDLQLFRVSERRLp------------rR-PRRLH-KAITSQP----------- 53 
XP_011221296  46 VSIHIIADPGESQPLQEAIDKVLAWIHPDLQLFRVSERRA---------------SRRRRK-PWKVAQP----------- 98 
Q6DIL6        25 VSIHIIADPGESKCLQEAIDRLLVWIHPDLQLFCVSERRVlkkkkp--sksfasH-------------P----------- 78  tropical clawed...
XP_032236696  52 CTLQIRTKKGEGGFLKNLYRPLLEGIDPTFQFICIEESED-------------------------VEYPltvwgdnlpss 106
XP_006006399  38 VSVHIITDPGNARTFQNAIDNLLAWINPELQLFRVSERGIckkqkks-csgivvQ-------------P----------- 92 
XP_001233732  49 VSVHIITDPGESKTLQQAIDKLLAWIHPELQLFRVSERRVs-------------KKHRKPD-KAGVSQP----------- 103 chicken
XP_002111349 111 -gkpkilSLGIQLFLHECnYGnyHDNI---RNYLQQSIWNIKLNVAlSSTyiKscPPNDNLESYVANGPMMPWWAIRTIH 186
8_pfamImport  57 -------SLAVILFLQEE-YG--EEQVlqlHRALRAPPWQFHHTEK-VNG--RllPYMPCSQDFFTLAAGTPLWAVRPVH 123
XP_040057281  63 -------ALAVIVFLRDG-NGg-EEPAlmlHRVLRRPPWSYHHTEK-VSNahPmlPLSPCSQDFFTLSSGTPLWAVRQIN 132
7_pfamImport  50 -------ALALILFLQEA-CGgeEEELlalRRALRRPPWRYHHTET-VSSr-RmlPLSPGSQDFFTLAPGTPLWALRQVH 119
2_pfamImport  54 -------ALAVILFLQED-FD--GEPIlqlHESFQSPPWHYHHTER-VHG--KflPYMPGSQDFFILVPGTPLWAIRPVH 120
XP_011221296  99 -------ALAVVLFLQEE-YG--EEQIlrlHRTLQRPPWRHHHTER-VPG--RflPYLPCSQDFFTLAPGTPLWAIRPVH 165
Q6DIL6        79 -------ALAIILFLQED-YG--EEQIlhlHKCFQKPPWQFHHTER-VHG--KflPYMPCNQDFFTLANGTPLWAIRQVH 145 tropical clawed...
XP_032236696 107 sdnfvctSLSVVLFLRET-FG--RLSAlsmQKNLGAEPWRFHHRIE-LPL--DvrPRVTARQDFYQAFPELPLWAISPVH 180
XP_006006399  93 -------ALAVILFLQEE-YG--EEQIlqlYKSFQQPPWRYHHTEH-VQG--KilPYMPCNQDFFTLANGTPLWAIRQVH 159
XP_001233732 104 -------ALAVILFLQEE-YG--EEPIlqlHETFQRPPWHYHHTER-VHG--KflPYMPCSQDFYTLAPETPLWAIRPVH 170 chicken
XP_002111349 187 SGKEVIRINLFVN--DLDNMLQFYEVILRQQPQIKRKDFCCFTLVRYPEFDFQFSLKALNKlSPKPTPTDDFLLEFFHTG 264
8_pfamImport 124 YGKEIVRFTVYCRheNFPDMVKMYQLVLQRELAQRREDFCFFVVYASLDTEVQLSLKRLPR-GQSPAPTESAVVEFRVQD 202
XP_040057281 133 YGKEVVRFTVYCRqeNYVHMVRLYKLLLQRGPTQRKEDFCFFVVYSNHEMEVQLSFKRLPR-GQRPVALEAAVMEVRVPD 211
7_pfamImport 120 YGREIVRFTVYCQhqNYGDTVRLYRLLLRRRVWQRKEDFCFFLLYSNPRLEIQLSFKRLPP-GRRPAVLESALLEVRVRD 198
2_pfamImport 121 YGKEIIRFTVYCRheNFASTMKLYELVLKRQPHQQKADFCVFPIYSNVDIDVQFSLKKLPR-GLVPTPTESAVLEFRVED 199
XP_011221296 166 YGKEIVRFTIYCRhdNYADILKFYELILRRSPSQRKTDFCIFPIFSNLDVDIQFSLKRLPC-DQTPVPTDSSVLEFRVKD 244
Q6DIL6       146 YGKEIIRFTIYCSyeNFADMMKMYELIIKKRVWRKKTDFCVFPVYSNMDFDIEFSLKRLVK-GQKPVPLESSLLEFRVRD 224 tropical clawed...
XP_032236696 181 YGNEHLRFHIVVK--NFNQMKYFYELLTGVTPRGNSPGFCYFPIYTQKGLDIQISLKCLPQ--VSPRPSSGYKLQFKVEN 256
XP_006006399 160 YGKEIVRFTIYCSyeNFADMVRLYKMIVKKEGCQRKLDFCFFTVYSNMDIEIQFSLKRLPK-GQYPTPTESAVLEFRVKD 238
XP_001233732 171 YGKEIIRFTIYCRneNFVDILKFYELILKRPVCQKKADFCVFPIYSNMEIDIQFSLKKLPK-GHVPMPTESAVLEFRVKD 249 chicken
XP_002111349 265 YSSLVNLLPDCVTLVSKKCWKIKDPEGNTLLLH 297
8_pfamImport 203 IGRLVPLLPHPCTPISEVRWQTEDYDGNKILLQ 235
XP_040057281 212 VGALVALLPRPCCPISDARWQTEDYDGNKILLQ 244
7_pfamImport 199 VGALVPLLPRPCSPISQVRWRTEDYDGNQILLQ 231
2_pfamImport 200 IRKLLLLLPYPCSPLSEGRWQTEDPDGNKILLQ 232
XP_011221296 245 IGELVPLLPNPCSPISEGRWQTEDLDGNKILLQ 277
Q6DIL6       225 FGQLIPLLPNQCSPISEGRWKTEDHDGNKILLQ 257 tropical clawed frog
XP_032236696 257 VGSLAPYCGGPLLPYGRNSWMTNDPDGNYVILE 289
XP_006006399 239 IGQLVPLLPNPCTPISEVRWQTEDYDGNKILLQ 271
XP_001233732 250 VGQLVPLLPNPCSPISEGRWQTEDHDGNRILLQ 282 chicken
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