Conserved Protein Domain Family
CAGE1

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pfam15066: CAGE1 (This model is not part of the current CDD release)
Cancer-associated gene protein 1 family
CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues. CAGE-1 is predominantly expressed during post-meiotic stages. It localises to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa.
Statistics
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PSSM-Id: 521636
Aligned: 12 rows
Threshold Bit Score: 644.591
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELW71759       1 MSELDVMNVNSLSQDLTH------SGSPLCMETSSTTSDLPQNEIKNVKRENESQSTLSEEIYNALDNLL-GDINIRNYS 73 
5_pfamImport   1 MMEADAMNASSLSQDFAY------SDSPFCLETSSTASDLPQNEIKNVKVENESKLTLSEDIYNTLGNLIgGDINIVKYS 74 
1_pfamImport   1 MSESDAVSVSGLPQDLVRlkdlmcSDSPNCVETISTLSDLSQNEIMNGERENESKFTLCEAFCSTVHDLSpGSHTGGCYS 80 
9_pfamImport   1 NLEADARNVSSLCQDLTR------SDSPFYMDTSSTNSDLPQNEIKHVKREDESKLTLAEEIYSTLDDRL-GDFNTGNDS 73 
3_pfamImport   1 M------NFSSFSQDLTH------SHFPLYMDTNSTTSDSPQSEIKNVKREDESKPTLSKDIYGTLDDEL-D----GEYH 63 
7_pfamImport   1 MSESDVWNVSSLSQDFTR------SESPVCVETSSITSVLPQKEIKNFKRKDEYKSTLSEDIFNTLDNLL-DDDNIGSYS 73 
Q5IR70         1 MSESETINVNGPSQDFSY------SDSPFCMEASFSSSDLLQSETKNVKRGNESTHTFSEDIYSTEGSLL-GDINLGNYP 73  house mouse
8_pfamImport   1 MSESDALNFSGLSEDLTH------SDFPCCMETSLSVSDLPQNETKNAKRENESKPTLSEDIYSTQDSL--GDINIGSYS 72 
6_pfamImport   1 MSEPDAIHISGLSQELIC------SDSPSCLE-SIPTSSSPQNERKNIERENESKATLSEDMCSTQDNVL-DDTDMGSYQ 72 
EHB06393       1 MSELDATHVSGLSQDLTH------SDSPSWME-SSPTSFFPQNETKNVKRGNESKPTLSEDMCSTQDNVL-DDTDIGSYP 72 
XP_056679377  45 PSEADATNIHTISEDLTH------SDSHLCEESSSITSDLLQDKIHKIQREKEPTFTIYKD-YATLDNFK-HDNSLKDHL 116 gray short-tail...
Q95JR0        30 ISESDTMNVSNLSQGIML------SDSPICMETTSTTCDLPQNEIKNFERENEYESTLCEDAYGTLDNLL-NDNNIENYS 102 crab-eating mac...
ELW71759      74 QKVLIQPIDA-SISSMRQFEPICKFHWTE-FNSEMTIFHNPTEGSSYTEKPELRGHLYNYAQE----EDSFKEENPMRT- 146
5_pfamImport  75 QNVLIEPPDT-SISSLKQFEPICKFHWTEaFTDEMTTFQNSMEGLRCTEKPELQSHMCHYEKDsnikKNLFNEENPIGI- 152
1_pfamImport  81 ENEQVQPVDT-SSFPLEQRDPLREVHWAEvANEKMRTCQHLTEGFSDANKPDLQSHEYTYVEEisikQDSFEEENPVET- 158
9_pfamImport  74 QNVLLQLVDP-STSSFRQFEPICKFHHTEaFSNEMITFQNLKEGLPYIVQPEMQIHVYYCAKDtnikEDSFKEENSLGT- 151
3_pfamImport  64 FNLLTQPVDT-SLSFFRQFEPICKFHLTE--------------------KPEMQSHVCNCPKDtnikEDSFKEENSVGTe 122
7_pfamImport  74 QNVLIQPFDTvSTSSLREFEPLCKFHCLEtFSDEV------------TEEPELQSHMYYYAKDtnrkQDLFNEENPMKT- 140
Q5IR70        74 ESEQNQPANT-RLSSLRQFEPICKFHWIEaFNDEM-TVEDLRGAFSYSEKPELPSQVYNDAADgsekPDPFKEESSVES- 150 house mouse
8_pfamImport  73 QKIQIEPINT-CISSLRQFEPICKFHQLEaFNDEMTTFQNLTEGFSYMEKPELQSHVYNYAKDtnikQDLCKEENPMET- 150
6_pfamImport  73 QNIKSQPINT-SISSLRQSEPICKFHWIEaFSDGM-MFQNLPEGFSYIEKPECQNTVYSYAKDnv-tQDSFKEENSIEA- 148
EHB06393      73 QNIQTQPVNT-SISSLRPCEPICKFHWIEaFNDEM-TFQNPAEGFSYIERPELQSPVYNYAKDsnvtQDPLKEENSVEA- 149
XP_056679377 117 ETVLISPDNTkSIIH-GGFDSICKFHKTEdLNNEGKLLRNDDDQLSSTGQPAPQNQFC--GSTssikQEKNLEQNDTVT- 192 gray short-tail...
Q95JR0       103 KNVLTQPVDTiSISSLRQFDTVCKFHCVEaFDDEM------------TEKPEFQSQVYNYAKDnnikQDSFREENPMET- 169 crab-eating mac...
ELW71759     147 -SISTNQNRLANAYVRP-PPRSPPVTPGS--GETLSYSENSLAESTARESALHPNQPQSFlyeesiqRSGRKPFYTeNSF 222
5_pfamImport 153 -SISTDKDLLANESVSE-PSRSPPLIRCC--GDKLNFMENSLAKSSAQGPALGLPQPQSF-------SDAEEPFNKeTSF 221
1_pfamImport 159 -SLSTDNDPFANECVRQ-SPSSPALIYCS--GETWDFTEKSLAACTARESALLHPPPQSCfceddvpYNVEKPSYK-GSF 233
9_pfamImport 152 -STSTNEEQFAHKCVIQ-PSGSPPVVHGS--GETVKFMEMSLAKSAAMESALKPSQPQSFwyeenvpSDVDKPFYEeNGF 227
3_pfamImport 123 fSTSTKEEQLAHECVRQ-LSRSPPLVHSS--GETLKFTETSPAKSAATEAALKPSQPQSFlyme---------------- 183
7_pfamImport 141 -SISTNKDQLAKECVRQ-PSESLPLLHCS--EETLKFMENSLANNTAKESAFNLSQSQSCfy------------------ 198
Q5IR70       151 -SISENKDELVPAPVRK-SPRSLCLNYYR--GEAQPLTEAPFVRSAVVDVGLNISQPQSFldkenvcKNGDNSSDReNCF 226 house mouse
8_pfamImport 151 -SISANKDQLAQECVRQ-SSQSPHLLQCN--GETLQFVEKSLAKSTAMESALNPSQPQSFlykegvlRNYENPFFKeNSF 226
6_pfamImport 149 -SISTTKDQPTHECVTQ-SSRS--LRHYN--KETLEFREKPLAPHNATEFILKPGQPQNFlyresmpRTVEDLDYNgDDF 222
EHB06393     150 -SISTTKDQCTHECVTQ-SSRSPSHYNYS--EETLPFTEKPLVTCTAMGSSLKPSQPQNFlykksvsRNVEDPSYSeNSF 225
XP_056679377 193 --IFIKKEVYTEQTLVN-APKSPHLTIYDefEEPLPISEESLFDSIIKDTSINLKKTSSFlfeknvcTEVGESYLKeG-- 267 gray short-tail...
Q95JR0       170 -SVSASTDQLGNEYFRQpPPRSPPLIHCS--GETLKFPEKSLAKSTAKESALNPSQPPSFvc------------------ 228 crab-eating mac...
ELW71759     223 SPLDLRVNYTTEETAVSSYEILNSGEISEMSVSHPKEVTEVGTDSPEAVSAWSPAGISWTSSMFRENCGTPGTEHSFESF 302
5_pfamImport 222 NLHDLRANCETEETAVSPSEIQNSGEMPEMSVSHQREARVEDVESPGLFSAWSPTDVSWSGGGFRGECKTSDTERSFENL 301
1_pfamImport 234 SRCDLRANDKTQETEVASKEIQNFGEISETSVHPQEEVTVESMGSPEIASTWRPADVSWSDGAARQKCRTPDKEQSFESL 313
9_pfamImport 228 NQLDLKANYATEKISVSSKGIQSFGDIPEMPVSHQKEVTVEDTDRPGTVSYWSPAVISWSSGASQEDSKAPDMEQSLESL 307
3_pfamImport 184 ---------nvpSIEGFLLTIQSFEDVPDMPVCCQKEAPLEGLASPRIASPWFPAGIPWSGGAPLGDGMMPDTEQELESS 254
7_pfamImport 199 ------------kIAVSSKEIQ----IPEMLLSHQKEVAAEDVERPGIALPWSPAGISWNSRKSQQTCKTPNVEHSFESS 262
Q5IR70       227 EQLDLRAIYKAEEPEVSSKEVQNSGEISELSVSHQEEVTEDGVDSLAITSPWSPAGI-FKGSGPQDNSLRPDREVSCEGL 305 house mouse
8_pfamImport 227 RLLDQRVNYKTEETEVSSKEIQNPEESPEMSVSQQEEAIAGNAESPGIALSWSP-GISKSGGNSWENRLTPDTEQSLEGL 305
6_pfamImport 223 HLYDLSVASKTEETEVSSKEIQISEESPEMSASHQDEVLAEDLESPVTALAWCPARLSRDSRAFQENCEIPDMEQSFENL 302
EHB06393     226 KLHDLRVNYKTEETEVSSKEVHIYEETPEVFVSHQEEVLVEGLESPRTASIWSPAGISRSVEASRETCVTPDMEQSSESL 305
XP_056679377 268 --FDQTAIHTAQVIFVNPKESKDAVEGPEKSNICPKKVKEESENHNENFLTYFT-DTSSWSEASIEDFNTQDAKQGFESL 344 gray short-tail...
Q95JR0       229 ------------kTAVPSKEIQNYGEIPEMSVSYAKEVTAEGVERPEIVSTWSSAGISWRSKASQENCEMPDMEQSAESL 296 crab-eating mac...
ELW71759     303 QSP-DEDMALNDILRKLKHTNRKQQTQIQDLQCTNLYLEEKVKELQMKMTKQQGLVKIINKLKENVEDLIEDKYTIMLEK 381
5_pfamImport 302 QPL-EEDMALNEVLRKLKHTNKKQQIRIQDLQCSNMYLEKKVKELQVKITRQQVLVDIINKLKENVEKLIEDKYKVILEK 380
1_pfamImport 314 QPL-EEDMALNEVLKKLKHTNRRQQMRIQDLQCSNLYLEKKVRELQGKTAKQQGFVDIINKLKGHIEELIEDKYNIILEK 392
9_pfamImport 308 QPL-EEDMALNEVLRKLKHTNKRQQTLIQDLQCSNKYLEKKVEELQRQTTKQQVFVD-INKLKEKMEELIEDKYRVMLEK 385
3_pfamImport 255 QSL-EEEMAC-EVLGKLEHTNRKQQSQIQDLQSSNKYLERKVEELQMQDTKQQVFVDIINELKAKVEELIEDKYRMMLEK 332
7_pfamImport 263 QPL-EEDMALNEVLQKLKHTNRKQQAQIQDLQCSKLCLEKKVKELQVKITKQQVFIDIINKLKENVEELIEDKYKVILEK 341
Q5IR70       306 EPL-EEDMALNEALQKLKQTNKKQELQIQDLHGKNLNLENRVQELQTKVTKQHVLVDIINKLKVNIEELINDKYNVILEK 384 house mouse
8_pfamImport 306 QPL-EEDMALNEALRKLKYTNKTQQVQIQDFQCKNLHLEKKVKELEMKITKQQVFIDIINKLKENIEELIEDKYNIILER 384
6_pfamImport 303 QPL-EEDMALNEALQSLQHANRQQQIQIQDLQCSNLHLQKKNKELQMKIIKQPVFFDIISKLEKNMEELIEDKYNMKLEK 381
EHB06393     306 QSL-EEDMALKEVLQILQHNNREQHMEIQDLQCSNLCLQKKNKELQMKIVRQPVFLDIINKLEKNMEELIEDKYNMKLEK 384
XP_056679377 345 TPLvEEHIDFNDVINTLKQDNHKQQNKILELECSNLYLENNVKELQMKISKQEVFVDIINKLKENVEELIEDKYKVILEK 424 gray short-tail...
Q95JR0       297 QPV-QEDMALNEILKKLKHTNRKQEARIQELQCSNLYLEKRVKELQMKTTKQQVFIDVIDKLKENVEELIEEKYKIILEK 375 crab-eating mac...
ELW71759     382 NGINKTLQNSQEVLANTQKRLQESKKEKGNLQLELKKIKINYVRLQKRCISAIRQKNRSVSYCIEMDKTLSKKEEeVARL 461
5_pfamImport 381 NDGDRTLKNVQEILSDTQKHLQESRNEKKTLQAELKKIKVNYIHLQERYMTEIQQKNKCVSQCIEMGKTLSKKEKeVERL 460
1_pfamImport 393 NEADRTLQNLRETLADAQRHLQESRKEKEALQLEVRKIKVSFIRLQESYVTEMQQRSVSVNQWTQTDRVFGIKEG-VQRL 471
9_pfamImport 386 NDTEKTLQNLHEVLTNTQKHLQESRNEKETLQLELKKVKGNYVHLQERYMTEMQQKDKTVSQCMEMNTTLSKKEE-VERL 464
3_pfamImport 333 SDTNKTLQNLHKVLTHTQNRLQEVKNEKETLQLELKRIKGNFVHLQEKYMTAVQQRDKTVSLCLQMNRTISEKEEeVERL 412
7_pfamImport 342 NDIKKTLQNSQEILANTQKHLRESRNEKQALQLEFKKIKANYTHLQERYMTEMQEKNKSVSECLEMDKTLSKKEEeIERL 421
Q5IR70       385 NDINKKLQDLQEASAHTKKHLQESKKDKESLQLQVKKIKVHYVRLQERYIAEIQQKNRSASQCLEIEKTLSKKDEeLQRL 464 house mouse
8_pfamImport 385 NDIKKKLQNLQEILANTKKRLQESRKEKEILQLEVKKVKVGYIRLQERCITEMQQKNRSVNQCIEMDKTLSKKEEeVRRL 464
6_pfamImport 382 NDMNRKLQNLQESLAITEKHLQESRKEKETLQLQVKKIKANYIHLQERYITEVQQKNRSVSQCIEMDRSLSEKEGeVERL 461
EHB06393     385 NDINRKLQNLQEILAITEKHLQESRKEKEMLQLQVKKVKANYIHLQERYITEVQKKNRSVSQCIEMDRSLSEKEGeVERL 464
XP_056679377 425 KDIENSLKNLQKASAEIKKQLEESILEKNTLILELKSMKTDYVLLQEQHKNELELKNKSLSYCLEMDKILNKKEEeIGKL 504 gray short-tail...
Q95JR0       376 NDTKKTLQNLQEILANTQKHLQESRNDKEMLQLQFKKIKANYVRLQERYMTEMQQKNKSVSQYLEMDKTLSKKEEeVKRL 455 crab-eating mac...
ELW71759     462 QRLKEELEKATTSALDLLKRERKVQEQEF-------QKYEKNNLEETQKLKSRLEKLVVQVN 516
5_pfamImport 461 QQVKGELEKATASALDLLKRERETRVPEFlslqeefQKHEKRNLQERQKLKSSLEELVTQVK 522
1_pfamImport 472 PRPRGGLEEVTPSALDLLKKEKDTQELEFlalqeefQKHEKKNMEERQKLKSRLQKSVTQVK 533
9_pfamImport 465 KQLKGELEKATTSALDLLKREKKTREHEFlslweefQKHEKKNLEERQKLKSRLEKLLTQVN 526
3_pfamImport 413 QQLKGELEKATTSALD-LKREKKTLEQEFlslqeelQKHKKENLEERQSLKLRLEKLLAQVS 473
7_pfamImport 422 QHLKRDLEKATASALDLLKREKETREQEFlslqeefQKREKKNLEERQKLKSRLEKIFTQCK 483
Q5IR70       465 QRHKGELEKATSSALDLLKREKEIREQEFlsfqeefQRREKESLKERRKLKSRVEKLVAQVK 526 house mouse
8_pfamImport 465 QQLKGEMEKATTSALDLLKREKETREQQFlslqeefQKHEKENLKEKQKLKLRIEKLIPQVK 526
6_pfamImport 462 QQLKGRLERANTSALDLLQKEKETREQEFlslqeefQKREKENLEERQKLKLRVEKSTAQVK 523
EHB06393     465 QQLKGELERATTSALDFLQREKETREREFlalqkefQKHEKENLKERQKLKLRNEKLIAQVK 526
XP_056679377 505 QNLRGELETVT-SALEILqt--------------efQRHEEVKIQERQELKSSLGKLVAQVK 551 gray short-tailed opossum
Q95JR0       456 QQLRKEQEKVTASALDLLKREKETQEQEFlslqeefQKRDKANLEERQKLKSRLEKLLTQVK 517 crab-eating macaque
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