Conserved Protein Domain Family
NCU-G1

?
pfam15065: NCU-G1 (This model is not part of the current CDD release)
Lysosomal transcription factor, NCU-G1
NCU-G1 is a set of highly conserved nuclear proteins rich in proline with a molecular weight of approximately 44 kDa. Especially high levels are detected in human prostate, liver and kidney. NCU-G1 is a dual-function family capable of functioning as a transcription factor as well as a nuclear receptor co-activator by stimulating the transcriptional activity of peroxisome proliferator-activated receptor-alpha (PPAR-alpha).
Statistics
?
PSSM-Id: 521635
Aligned: 29 rows
Threshold Bit Score: 261.107
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EFN86794      29 TTLYLRADGANDT---LHYLWDFaiGRPSVLLALTSS---SAW---LN-----------ITWPDYLDK------QENSIH 82 
XP_002429837  19 SINYVKAEGPNDT---LHYLWDFt-HKPTLFLAKTDL---DTN---FH-----------FDCNDFING------YPHSFN 71 
XP_032514324  46 TLVYVRCDGSADS---IHQIWDFtrHLPTVIFTITSL---NST---LN-----------VTWDGT---------TPKSFA 96 
XP_001605131  51 RIAHVRAVGPNDT---LHYLWDFt-ENPTILIAVTSH---TAK---LQ-----------IDWKKYLSR------TPNSLN 103
EFN61421      44 TTLHLSADGPNDT---LHYLWDFi-GNPSVLLALTPP---STS---LN-----------ISWEDYLAR------RENSVH 96 
XP_002109294  56 NLIHVMAKNPYNNghdIHYVWSTi-GSPAVLIAYTVK---STE---IK-----------IDWAKFISDn-----PANSIT 112
EDO37624      55 SLVYVSAESA-DHdnvVHFVWSGf-QGPSIINAYSEKlpeKHAkpgLN-----------VKWENLFKNd-----TEGALE 116
XP_015793561  65 DLVYTHSTDNDTS---IHFISSTlgGFPGFFITRTAT---PTI---LQ-----------INWDSLL-Nn-----CSDSFN 118
XP_001746362  34 TSVEI-AMGSLDA------------QPGTLFLAVASQ---DFTyfaLNfddhvdpgavaINWTLFRNPtitpalVAEAIT 97 
XP_001867233  50 TVIHIRADSAKDT---IHYVWDFt-GKPTILVALTDK---SAT---LD-----------IQWDDFLGG------KPESVR 102
EFN86794      83 FSEPP--VYVFGVIVNKIIEFNDVNDTALIDTaDVASTn--vLRPEYFYWRLVS--MSKTD---EFVYLDMEGnSYND-- 151
XP_002429837  72 FTKVP--SYEFSLLFNKLIEFNDVNDTGILTPdSKTIT----YDMKNFLWETTG--KLIGDkngKFVKIVMTGfNHSD-- 141
XP_032514324  97 LSEKP--HYSFATAIDKLYEYNDLDDNGFIVPkYPQHE----YSLSKVIWHLNE--SRFAD---KEVMVRLNG------- 158
XP_001605131 104 FTEKP--LYTFGVAIERILEFNDFYNTSRIDEvNDKNIt--eINFENFQWHHEN--MTKHD---NLVQFYTYAdSYKD-- 172
EFN61421      97 FSEKP--TYSFGMIINKIIEFNDVNDTALIDTaDIANMn--vLHLEYFNWQRVS--LTQNN---DFVYLNMEGnSYHD-- 165
XP_002109294 113 FDPEP--FYTSGMQLTHLIEFVDVNDTARLNS----SAeihmYPFHDMLWDSTS----------WVNSEKSDGrVNFT-- 174
EDO37624     117 FTPKV--DYITAFSLSSVLQFADPKDEIYFTKtGGVIE----HNLRSVQWRKVIldKDNDN---ATFVGEFLG------- 180
XP_015793561 119 LPSIP--DDSIGVLLLSFFN----------------------IDHKDIHWT-----LDKNGsinCDSSTCKFGyTSSE-- 167
XP_001746362  98 IKSGNrlQYGQAFVLDALLEFNDTKVEALHREm--------pLSLRSSAWTVKP------------------GaTSDTlt 151
XP_001867233 103 FSKQP--VYTFMTVINRIFQFDDIGDTGTMTNqSKAFV----YDPHTFAWNRTLlwASERD------------------- 157
EFN86794     152 TakNISRYGSIklsLRGFCTVDHSDIVPHMLHTENSTQVDIILDDI-QTNasFSRS-RFA-------------------- 209
XP_002429837 142 P--NYNLMGRV---ITAFGFENHDVELPRLLHSPNSTQIKIILDDL-KSDsgFNESrRFA-------------------- 195
XP_032514324 159 FidDERVKGVInvkLDLIPFKDYATDLPHLIHTANSTLFDISLTNL-TTRshYNAS-RFA-------------------- 216
XP_001605131 173 QynNV-RSGNIsflMHGFGAVNHSNITPRMLHSENATQVDIVFDHL-QVRkdFLRS-RLA-------------------- 229
EFN61421     166 TakNISRYGSIklsLRGFCTLDHADIVPHMLHTENSTQIDIILDNL-QTNetFSNS-RFA-------------------- 223
XP_002109294 175 TeyGTNTNGSIllsFDAGKSKERISRLPFLMITSNSSAVDLALHNL-STI--SNHS-RFG-------------------- 230
EDO37624     181 --------GTIsfsCAAADHDDRDEEPPRPRYSSNSTRFTVNLSHLk-----TNSTdRLA-------------------- 227
XP_015793561 168 ---QSSLNETIsisLEMKNKQSSFEDLPHLLFSPSSMHIDLQITNLdKSQ--MNKS--DG-------------------- 220
XP_001746362 152 FntSFTRDCSVnvsLLMHTGKGYAAVAPAIPIMPNASDINLILLGC-NAT--IKNS-RFGtrnhvytsrtvrstiaplsr 227
XP_001867233 158 VmlAINAKNDFlfkLNAFSMRDHGLDFPHLLHSSNSTQVDIVFNNV-SSK--FDRP-RFA-------------------- 213
EFN86794     210 ----------IELL-VVGGGD-------PEIPMFVDPKKSLDDEHTPGIFEVV--EVRTPPYKDlDIalnAGAYLQWRPV 269
XP_002429837 196 ----------LEML-LVSSNEdddddikKNSSSKIILRKNTDDENSPGIFSMV--DVMTPGSLNqKH---RGAFLQWRPI 259
XP_032514324 217 ----------LHLL-MASTDH-------VTDTMHFTMRKSLDDEHTPGVFEII--EIKTPSLYHtG----EGGYLQFRPV 272
XP_001605131 230 ----------LEFL-VVSEIS-------PNLTLNVDTKRKLDDEFTPGIFEVM--DLSTPVINE------RSAYLQWRPV 283
EFN61421     224 ----------IELL-MVGGGD-------PDILMFVDPKKSLDDEHTPGIFEIV--EVRTPPYRElNGalnGGAYLQWRPV 283
XP_002109294 231 ----------LEMM-FVNSYTqk----pS----KFKSYRSIDDEYCPAVFTMIdvNLYGED----AS---NGSYCQFRPV 284
EDO37624     228 ----------LEFV-SVVKSE-------ESMPSCSREFQSIDDEHSPGIFRTVviN---------NTyatYSSFISWKPV 280
XP_015793561 221 ----------IKLL-VFS----------SFNEYKETLERTIDDENSPGVFTKR--TFLFSQDNEnNT-----NFLQWKPV 272
XP_001746362 228 erhfsnlmpfLQTV--------------LATDMKLKTEMSIDDEHSPAVFKLS--ILGTEKAPQaPSnqvTHGYLAFKPV 291
XP_001867233 214 ----------LELLfVVSEQAv------AGSDFEITKRKSLDDEHTPGIFEII--DVLSPGAFKfS----AGGFIEYRPV 271
EFN86794     270 SYNTGSREVTSSTETMQYPPKK----------VSNRTNAIDNSMLYCYYGKDTDa-LLLQKVTVSFGSKGDGFYRKTSYS 338
XP_002429837 260 IYVTKNPSITNSSEIVAYNLANv--------sPDSENDDDLIDSLPLIYHGDDIknCLIERIVVSMGSSQDGFYKKTNYT 331
XP_032514324 273 GYTQPERGVASSTVAHVSDFNR--------------TRLPYRSTLRLFYGGSDIadLLIQDMFVSFGENGDGFYKQHNYT 338
XP_001605131 284 SYTDELRDVTDSVGSIFYPVKK----------ATVDDYFNKNNLLYMYYGENLFn-NLVQRMNVSLGAKGENYYKESQYA 352
EFN61421     284 SYNSALRDVTSSTETMQYSPKR----------ISKYTNAVKNSMLYCYYGNATN--LLLQKLTISLGSKGDGFYKKTNYL 351
XP_002109294 285 CYVNPHRALSGQKEVQYYEFVQa--------------SILPHGILTAFYGEQD---INIYGMNITFGQKKDGFYVATQFT 347
EDO37624     281 MYTKLDRGLKTQLPAFNYLYKNgkfeqtkissKHCFHLTERKTLLPKIILGAMSkdIITYPIRLSSGQKKDGWYKATQLL 360
XP_015793561 273 AYNSKERVMSKTMEINSSHLTDa--------eLPRL-NYPLYCFHKQFYSN-----YSVHKFNASFVQEGKSSATKIDLI 338
XP_001746362 292 VYGSASRGSSNMTSVQt--------------nVSSLVPVDNATLPSSLFGGAGEg----sELILLFGSKGDGWENASSYY 353
XP_001867233 272 SYTHPERDVSTSTETHQSEPQT----------VESPANALNSTLAYAIYGQELDr-LLVQGMNISFGFSGDGFYTKTNYT 340
EFN86794     339 TWTFIIGYGTPPEERFSNLVIMIISIGLGLPLLIMVIVGLYLCIRRMPK 387
XP_002429837 332 SWTFLMNYGSPEQEKFSLLVILVMCIGLGLPTLLIIIGGLYLCTKPLRR 380
XP_032514324 339 AWSFTIGYGTPPVEKFSLFVIMIISIGLGVPLALALSGILYVVLRRYRQ 387
XP_001605131 353 TWTFIAGYGTPPDERFSVMVMLIISIGVGVPVILIMTLGIWACLRRKNP 401
EFN61421     352 TWTFIIGYGTPPEERFSSLVIMIISIGLGLPLLIMVITGLYLCIRRMPK 400
XP_002109294 348 SWTSTFGFGIPPVEKLSLAIIMIISVGLGAPVVLLIFGGIGVFIKARRK 396
EDO37624     361 SWSGQAGCGQPLFDSISKTLYITIIAGLGIPA-LIILGGFYCLAADLRK 408
XP_015793561 339 TWSLIFGLDQPPKEKLSTFLQLMLFVGVGMSFVVMFVSLIYVVAKKWQK 387
XP_001746362 354 M-SAVLGTGDHGSNQFSFALLMTTIVSFGVPFIAFIVGGVYAVWKRSRL 401
XP_001867233 341 TMTFQVGVGMPPVEQLSAFVLIVAGIGIGVPLVMLVFGGGYVCLRKMRA 389
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap