7EEB


Conserved Protein Domain Family
CATSPERG_beta-prop
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pfam15064: CATSPERG_beta-prop (This model is not part of the current CDD release)
CATSPERG beta-propeller domain
The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex is involved in sperm cell hyperactivation, a process needed for sperm motility, which is essential late in the preparation of sperm for fertilisation. This complex requires four auxiliary subunits (beta, gamma, delta and epsilon), which play a role in channel assembly. These are multidomain proteins which share a similar domain organisation. This entry represents the beta-propeller domain of the gamma subunit (CATSPERG).
Links
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Statistics
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PSSM-Id: 521634
Aligned: 4 rows
Threshold Bit Score: 717.418
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7EEB_F        208 FLKRDASGKSLFAIGYESLVLKSSHFRLSKSRPLWYTVNHAPVFILGGFYDEKSILFSDSNFQDYVLLELSIDSCWVGSF 287  house mouse
1_pfamImport    1 FLERQRDNSLQFTVGNELFDLIPRYFVNVPSRPLWYTVDQAPVLILGGIPEEKAILLTDTNFEDFFLVELSIDSCWVGSF 80  
2_pfamImport    1 FLKRKRYNTIEFLVGDEISDVSPRAFVNVPSRPLWYTVDVSPVLILGGIPNEKRVLMTDTSFKDFSVVELSIDSCWVGSF 80  
E9Q355        208 FLKRDASGKSLFAIGYESLVLKSSHFRLSKSRPLWYTVNHAPVFILGGFYDEKAILFSDSNFQDYVLLELSIDSCWVGSF 287  house mouse

7EEB_F        288 YCPILGFSATIHDAIATESTLFIRQNQLVYYFTGTYITLFDKSHGSSRWVRVLPSECIKRLCPVYASGNGSEYVLALTTG 367  house mouse
1_pfamImport   81 YCPQANFTATIYDAIATESTLFIRQNQLIYYFTGTYTTLHETNHGSGRWVRILANECVKKLCPVHFHSNGSEYVMALTTG 160 
2_pfamImport   81 YCPHSGFSATIYDAIATEATLFIRQNQLVYYFTGTYPILHESNRGSGSWVRVLASECIKKLCPVYFHSNGTEYVLALTTG 160 
E9Q355        288 YCPILGFSATIHDAIATESTLFIRQNQLVYYFTGTYSTLFDKSHGSSRWVRVLPSECIKRLCPVYFSGNGSEYVLALTTG 367  house mouse

7EEB_F        368 KNEGYIHIGTITDGLVSFEMVPDGWSVCEKLPGKNCSIDWATYIADERNLLLLVKID---SGQFYL-VNFNTE-FKTLNI 442  house mouse
1_pfamImport  161 KHEGYVHFGTITDGRVSFELLPRQQSVCNGIRVVNCSITWAVFIAGDYDLLLLVEIEepaSRKYFLvVSYNLV-SDYLVI 239 
2_pfamImport  161 KNEGYLHFGTIRDGSVSFEMLPRERSVCEHIGVDSCSITWAEYLADDYYLLLLVESKhntAGTYFQvVGYSTKnNDALTQ 240 
E9Q355        368 KNEGYIHIGTITDGLVSFEMVPDGWSVCEKLPGKNCSIDWATYITDERNLLLLVKID---SGQFYL-VNFNTE-FKTLNI 442  house mouse

7EEB_F        443 LYKIPEFIPEAKELDFLVLLDTVTYTNTPMTPKGLFFNTLNNMLYIWGNFILQsynreefifladfpkestikymvnsfk 522  house mouse
1_pfamImport  240 LYTIPEFIPDARGLEFLMILGTESYTNVPMVPKGMSYNEYNNLLFIWGNFLLQ--------------------------- 292 
2_pfamImport  241 LYRIPEFIPDARGLEFLMILGTESYTSTPMIPKGMFFNPYNNLLFIWGNFLLQssnkknyiyladfpmelsikylvrsfh 320 
E9Q355        443 LYKIPEFIPEAKELDFLVLLDTVTYTNTPMTPKGLFFNTLNNMLYIWGNFILQsynreefifladfpkestikymvnsfk 522  house mouse

7EEB_F        523 gqmavvteneeIWYFLEGGYDVYQVVPSQGWETYHNLQKMQKSSFHSEDESLVSLFFEDGKLFQLVYLFDVGKERLVKRL 602  house mouse
1_pfamImport  293 -----------IWYLLEGSYQVYKLFPSKGWELYLSLQLMQQSSLYAPNETMITLFYDDSKLYQLVYLIDKQQGRLVKRL 361 
2_pfamImport  321 gdmaivteteeIWYLLEGSYKVYKLFPSKGWGIHTSLQAMHQSSFYSHNETMVTLFYEDNELYQLAYLINNQEGKLVKRL 400 
E9Q355        523 gqmavvteneeIWYFLEGGYDVYQVVPSQGWRTYLKLQKMQKSPLYSTNESLVSLFYQDENLFQLVYLFDVGKERLVKRL 602  house mouse

7EEB_F        603 LPVGTLMEY-NLPKPFTVVNQGNYQAISFTHTCPFKEIHLIDVP 645  house mouse
1_pfamImport  362 VPVEQLLMYqQLGNHYLLEQQGSHLTLSFANFCPFTVMRLLDLP 405 
2_pfamImport  401 LPVEKLLMY-QIHSQYDMERQGSHLTLSFTNPCPFTAMHLQRLP 443 
E9Q355        603 LPVGTLMEY-NLPKPFTVVNQGNYKMITFTNTCPFKAIHAVDVP 645  house mouse
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