Conserved Protein Domain Family
TC1
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pfam15063: TC1 (This model is not part of the current CDD release)
Thyroid cancer protein 1
Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.
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Statistics
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PSSM-Id: 521633
Aligned: 6 rows
Threshold Bit Score: 90.2662
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007238793   4 YASSESRRVTPRVHGSGFDTARRKRAAPHIFEQVREDALVRLFRKAGDAKAEERARSVFaaaASHEPGETARALMALH 81  Mexican tetra
XP_001232955  10 SAMSTSLRVSPSVHGYRFDTALRKKAVANIFESVDEESLQKLFKHSGDKKAEERAKIILd--TDQDVEEKARALMALK 85  chicken
XP_023564889   1 MGTPASVVSEPPLWQAPTEARGRKQASANIFQDAELLQIQGLFQRSGDQLAEERAQIIW---ECAGDHRVAEALRRLR 75  degu
XP_015201894   5 AAPAAAAPASPSQLWRLSGRRSRKAASPDIFRGVHLRQLQRLFRRSGDQQAEQRAQLVW---GRSDAAGLAQALTRLR 79  spotted gar
XP_022619439  15 ASPPSSMVAGPSSLWRLAERRSRKAGSGNIFSDVNLWQLQRLFKAAGDQDAEQRAQLVW---GHGDEAELAQALIGLR 89  greater amberjack
XP_014325207   6 ASASPSVVASPSSLWRLAERRNRKSGSGNIFSTVNLWQLQRLFRAAGDEDAEQRAQLVW---GHRDEAELAKALVALR 80  southern platyfish
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