Conserved Protein Domain Family
DUF4536
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pfam15055: DUF4536 (This model is not part of the current CDD release)
Domain of unknown function (DUF4536)
This domain family is thought to be a transmembrane helix. It is found in eukaryotes, and is approximately 50 amino acids in length. In humans, it is located in the chromosomal position, C9orf123. The family contains the uncharacterised Sch. pombe protein TAM6 which is found in the mitochondrion.
Links
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Statistics
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PSSM-Id: 521631
Aligned: 18 rows
Threshold Bit Score: 58.098
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Download Cn3D
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_016279740  29 GCLSCRLLSGVGLLGAGGYVYWMARR-----PMKLGYYPSPGTIFQMVVGIS 75 
NP_001373262  23 DCWSCRLLSGGGLIAAGIYVFAQVHR-----R-NLGKPPTVSAVLQMMFATG 68 
OWR46846      11 DCTPCRIVGSIGLVSIGAYLANAAFK-----NKTTPGKVLVSTISFAFVTLG 57 
XP_025268809  17 DCLECRLLSGGGLVAAGLYVCHHSKQ-----HQNQMGKVAMYSIASVLVLLG 63 
Q16JW2        12 DCLPCRIVSGTGVLGMGVYVWIQAKK-----RPQAVGRFAMYGVAAVAGGIG 58  yellow fever mosquito
XP_002072790  18 DCWACRLISGFGMMGIGAFLLAQAKR-----RNRPFENYTMKSLAAAAGFLG 64 
XP_001990720  18 DCIACRLISGFGMIGIGAYLLSQAKR-----RRSPVEHYAMKSIATVAGFLG 64 
XP_001966764  18 NCLACRLYSGFGLLGIGAYLLVQSKK-----RPKPLESYTMMSLAATMGVLG 64 
1_pfamImport   1 DCLPCRLVSGFGVIGMGVYIAVQAQK-----RTKPLGRFTMLGIAAVAGSIG 47 
XP_011049062  39 DCLPCRLVGASAFTGLGVYAYVQSRRlphnvPLYRTKRFGILGLA-TAFALT 89
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