8TO0


Conserved Protein Domain Family
TKTI1
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pfam15041: TKTI1 
Tektin bundle interacting protein 1
This family includes Tektin bundle interacting protein 1 (TKTI1) which has been recently characterised as a microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. It is located at the center of the tektin bundle where may function to recruit tektins or stabilize the bundle.
Links
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Statistics
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PSSM-Id: 494778
Aligned: 7 rows
Threshold Bit Score: 327.635
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8TO0_A3       23 PDHLYRNDYVSLEGPRWAPAIKQAVRWKFTPMGRDAAGQVWFTGLTNSEPGDAWYKLPRALDTPYREAHTRWHGCFQSRQ 102 house mouse
1_pfamImport   1 ETSFPADDYLSLEGPRWAPAIKQATRWKYTPMGHDAAGQLWYTGLTNLDSREAWYKLPSALDRPFREAYNRWHGCSRHRE 80 
A6H6Q4        23 PDHLYRNDYVSLEGPRWAPAIKQAVRWKFTPMGRDAAGQVWFTGLTNSEPGDAWYKLPRALDTPYREAHTRWHGCFQSRQ 102 house mouse
XP_003506494  23 PAPLYSNDYMSLEGPRWAPSIQQALRWKFTPMGQDAAGQAWLTGLTNSEPRDAWYMLPRSLDSPFREALTRWNGCFQSRQ 102
XP_005332264  40 PASLDSDDYEALEGPHWTPAIKQATRWKYSPMGHDAAGQAWYTGLTNSEPREAWYTLPRDPESPHREAYSRWHRCHNHRE 119
XP_003421961  23 PAPLYSDEYLALEGPRWAPAVKQATRWKYTPMGRDAAGQQWYTGLTNSEPRDAWYTLPRELDSSHRAAYTRWHGCHSHRE 102
ELV09281      94 PPLPPSDDYLSLEGPRWAPAIKQATRWKYTPMGRDAAGQLWYTGLTNADPREAWYNLPRAPGSAFREAYGRWHRCYGHRE 173

8TO0_A3      103 RGLPPAYTQHLREMAFWDPAITAQYLNSGPRWGCMQWRDRQIRGKEFVVTRNQFGAKLPWR-SDYVPLLSLPQRPRFTAQ 181 house mouse
1_pfamImport  81 CSLPSAYTQHLRETAWHDPIVPAQYLDPSTRWGSMLWKDRPILGKDYVVNRNQYGVEPLWSaSDYVPFLSAPQRPPHTTQ 160
A6H6Q4       103 RGLPPAYTQHLREMAFWDPAITAQYLNSGPRWGCMQWRDRQIRGKEFVVTRNQFGAKLPWR-SDYVPLLSLPQRPRFTAQ 181 house mouse
XP_003506494 103 RGLPSAYTQRLRETAFWDPTLPAQYLNPGTRWGCVPWRDRRIRGKEFVVNRNQFGAPVPWR-SDYVPYLSPPQRPRYTSQ 181
XP_005332264 120 RGLPPAYTQRLRETAWHDPTIPAQYRGSSTRWGNALWRDRPLRVKDYVVNRSRYKAEPHSHvADYVPYLSVPQRPRYTTQ 199
XP_003421961 103 HSLPSAYTQRLREASWYDPTIPAQYKTPSTRWGSLLWKDRHIRGKEYVVNRNRYGVEPPSQvSDYVPYLSPPQRPRYTTQ 182
ELV09281     174 RSLPSAYTQHLRETAWYDPIVPAQYEGPSTRWGSMLWKDRAVRGKEYVVNRNRFAAEPSWRaSDYVPYLSAPQRPRYTTQ 253

8TO0_A3      182 DFRQRGLQRPCPAIGQ-PPPAFTP 204 house mouse
1_pfamImport 161 NYLQWGLEPYCPSTGQwLPPGPTP 184
A6H6Q4       182 DFRQRGLQRPCPAIGQ-PPPAFTP 204 house mouse
XP_003506494 182 DFKQLGRQRPCPATGQ-MPPTFTP 204
XP_005332264 200 NYRLWDLDPYCPATDQ--PSTYTP 221
XP_003421961 183 NYRQWNLEPYCPSSNQrPPSIYTP 206
ELV09281     254 NYRHWDLNPYCPSTNRrSPPGYTP 277
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