Conserved Protein Domain Family
Beta-prop_CATSPERD

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pfam15020: Beta-prop_CATSPERD (This model is not part of the current CDD release)
CATSPERD, beta-propeller domain
The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex is involved in sperm cell hyperactivation, a process needed for sperm motility, which is essential late in the preparation of sperm for fertilisation. This complex requires four auxiliary subunits (beta, gamma, delta and epsilon), which play a role in channel assembly. These are multidomain proteins which share a similar domain organisation. This entry represents the beta-propeller domain of the delta subunit (CATSPERD).
Statistics
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PSSM-Id: 521607
Aligned: 13 rows
Threshold Bit Score: 472.955
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_020646580  50 GEPLRFSHEDPLLIQHPCGKQ-------Fkrg-iapAIYLGPQVFLSLDRFESSLLPVVIPKEMTVSPALVSAAAFiQTT 121
4_pfamImport   1 PDQLYFSSPTPRLIKHPCQER-------V-------ALYLGKEVFFTRDDFESSLLPFSIPASMMVGKPEITSAHF-AGS 65 
7_pfamImport   1 GTVLNFSHPEPFLLQYPCNEDdpwghpsP-------ALYLGEKIFLSTNGFRTSIPPLTIPNELEPSSALVSAAAFvKRT 73 
2_pfamImport   1 GTVLSYSRTEPSLLQYPCNDS-------YawgrlspALYLGQKVFLSIDAFKTSLLPMTIPDDLETPNASVSAAVFvKGG 73 
1_pfamImport   1 GTVLSYKYKDPRLIPHPCEAF-------YfggqtppAIYLGEKVFLSQDNFQSSLLPMTIPAIIESSPAEVTSALFvQNN 73 
XP_015856278  38 GDRLFYAFSSTYVLRDICHSD-------T-------VLYLGKKIFISKDKFESSLRPLTIPKSMRAGGASVTSALFtSNS 103
XP_017452125   5 EDLLFYAFSNTVVVKNVCKTD-------I-------AVYLGQRVFITKNRFEASILPLTIPKSMEVKMPSITSAHFvSDA 70 
6_pfamImport   1 GDILRSSSTRIYLIKHPCKEN-------I-------ALYLGKQLFFTRDNFESSLLPFAIPTSLQVGVPQVTSAHF-IGS 65 
3_pfamImport   1 GDVLYFPSMTPRVIKHPCRKN-------V-------AVYLGRQIFFTTDDFESSLLPLTIPTSMQVGVPTVTSAHF-IGP 65 
5_pfamImport   1 GDLLYFSSRTTRLIKHPCRRN-------L-------AVYLGARVFFTTDNFGSSLLPFTVPTSMQVGVPAVTSAHF-AGP 65 
XP_023588859  47 EDILYFSSRTTSLITHPCKRN-------L-------AVYLGARVFFTTDSFGSSLLPFTIPTSMQVGVPAVTSAHF-AGP 111
XP_023500280  60 PDRLYFSSMTTRLIKHPCKKN-------V-------ALYLGRQVFLTTDNFESSLLPFSIPTSMQVGTPKVTSAHF-AGP 124
XP_028377724  65 GDLLYFSSMKTLLIKHPCKKR-------T-------ALYLGRQLFFTRNNFESSLLPFSIPTSMQVGTPEVTSAHF-AGS 129
XP_020646580 122 RVLLVVNGNIFIYFYS--PwTIWKQSIGINYPVTELSNYDCCYS-FiY-PGCLEISSIVLAYDTGNLVEDSHIFYSLDGG 197
4_pfamImport  66 VLLLVVNQKVYIFDYE--Y-NLWSTSIGLDDPVSHISGDNCCYS-G-Q-HFCMDINDLVFAYFLGEPVRQTKIYFSSSQG 139
7_pfamImport  74 KLAMVINGRVYSYYFKagE-EEWILAQGIDSLVTELSNTHCCYP-G-QdLACKDISMKIFAYEIGHSPSKSHIFLSENGG 150
2_pfamImport  74 WLVMVINGRVYLYFFTggE-EEWIPVVGIDSLVTKLSNTHCCYS-EpD-PDCPTTSMTIFAYETGHSASQSHVFMSKNGG 150
1_pfamImport  74 RALFVINGKVYVYFYS--TwKTWKVSAGIDSPVTDITNMDCCYSlK-D-INCYDTSNFIVAYTTGKPTESTDIFTSKNGG 149
XP_015856278 104 KLLLVVNKKVYMYNYL--S-NRWHKAIGIYQPVSHISGDKCCFK-N-E--FCLELSYKVFAYLRGGPLPRTKIYFSDNGG 176
XP_017452125  71 MILFVIDGKVYSYNFI--E-DIWRTVNGITEPVSHISGDPCCFE-G-Y--FCLELSNNLFAYFRGGQMPGTNIYFSNNGG 143
6_pfamImport  66 SLLLVVNQKVYIYNYE--D-SSWNVSLGIKHPVSHISGDTCCYV-E-T-IFCVNIGNLIFAYLHGDQISHTNIYISTTGG 139
3_pfamImport  66 SLLLVVNWKVYIYNFE--D-ASWEVPVGIRHPVSHISGDHCCYV-G-N-TFCVHMSFSIFAYLHGEPVSQAHIYKSTTGG 139
5_pfamImport  66 VLLFVINQKVYVYDYR--A-NSWNAAVGVKHPISHVSGDNCCYS-Q-N-SFCLDIGDSIFAYLYGEVVSRANIYYSNTYG 139
XP_023588859 112 VLLFVINQKVYIYDYQ--T-NSWNAAIGIEHPISHISGDNCCYS-Q-N-SFCLDIGDSIFAYLYGEMVSQANIYYSKTFG 185
XP_023500280 125 VLLLVLNQKVYIYDYE--V-NSWNASVGIKHPVSHLSGDNCCYS-E-H-PSCMDISNSVFAYLHGDQVSEANIYFSDSCG 198
XP_028377724 130 VLLLVVNKRVYVYEYE--D-DSWRASIGVRHPVSHITGENCCYD-K-H-PFCADISDSIFAYLRGAEISQTTIYISETWG 203
XP_020646580 198 YVFQPLLSRP--HTDGILLGVYNFASISEIGMLLNK-----T------EgnvtS---IYFMYGDFrDMRN-----ETGTP 256
4_pfamImport 140 YGFQKLVHKIqeQEFGSLGGIFYFHSLSQIGMLFVV-----Y------E----K---AMFKYSDH-PLNR-----TYGEV 195
7_pfamImport 151 YSFTPVKLSp--ELPGVLLGVYNFVSLSQTGVLIRH-----SdgerkgG----E---AYFIYTNG-NLSQtsshiSMGFH 215
2_pfamImport 151 YMFTPVKLSP--GLQGVLLGVYNFVSLSQTGMLINHthsgrE------E----KaaeAYFTYTAG-NISHi----AMGFH 213
1_pfamImport 150 YRFVKTSPAGy---ENALIGIYNFVSLAQLGVILNKtd--gD------G----E---AYFTYTDM-NLAHq----EQGAE 206
XP_015856278 177 FAFQSLASEKldGLEGTLGGVFHFHSFSQVGILEVK-----D------K----L---GSFHYMEH-PLNH-----SAGIP 232
XP_017452125 144 FSFELLNSDRmsHLKGLLGGIFHFHSLSQVGILLVE-----N------N----L---GTFHYLEY-PLNH-----STGVP 199
6_pfamImport 140 YSFKKYTHEKqeELLGVLGGIYHLHSVSEVGLLVID-----G------E----K---AMLKYSYH-PLNR-----SFGLA 195
3_pfamImport 140 RRFKKYTYIGqaDLVGSLGGIFHFYGLSQIGLLIID-----R------Q----K---GTFKYSHH-PLNR-----SLGLA 195
5_pfamImport 140 YTFQKFAFYHqeALLGYLGGIFFFHSLSQIGLLVLD-----G------T----K---AKFVYSDH-PLNR-----SFGLP 195
XP_023588859 186 YSFQKFAFYRqeELVGSLGGIFFFHSLSQVGLLVLD-----G------T----T---AKFVYSDH-PLSR-----SFGLP 241
XP_023500280 199 YTFQKFAYERqaELAGSLGGVFYFHSLSQVGLLLID-----Q------G----K---AMFCYSHH-PVNH-----SFGLP 254
XP_028377724 204 YKFHKYVHERqtAQVGALGGIFHLHSLSQVGLLTSN-----Q------G----K---AKFVYSDH-PLNQ-----SFGLP 259
XP_020646580 257 FELephdNER--VQ---S--ILPPGMKGYIKFWTQDSFVSSSNNGLTTEGITIIPTDSYPNkTLPLHEDGVCFVAVSSTE 329
4_pfamImport 196 FDY----AET--FD---I--LVTPGQRGILLLWSQKGLMVSRNAGQLISPVWVQERPNTQY-SIFEANITIHNVAANENE 263
7_pfamImport 216 LKF----TRG--HD---IhrIQHPHLWGFTILWNNDTLLVSSNNGLLVEPVTVLEFSRNSHp--F-PGNGLCHVAISKTE 283
2_pfamImport 214 LKS----TGDpdVQ---V--IQDSDLSGFTILWNKDSLLASFNNGLLVEPVTVLHTREFPDtSPPFPGSGLCHVISSNTE 284
1_pfamImport 207 FDM----KLY--ADesvIg-IIPPGLRGFILLWTKDTFVFSFNHGLNVALITVHPTDKYVNvTLP--VQGLCNVAANRNE 277
XP_015856278 233 FKY----NDP--LD---V--IIKPGQRGFLVLWNQTSLLVSPNSGQIIETVQLWRGNTIVTpNISDMGINIHSIASNTYE 301
XP_017452125 200 FLY----ESP--LE---V--IIKPQQRGFLILWNQKTLLVSSNSGQIVEAMQLMEEGNINDlNVEHAKLTIHSIASNTYE 268
6_pfamImport 196 FDY----NGT--LD---I--LISPGQRGVLILWSERTLLFSHNSGQLFDSVWVYDGPYDIYpSVFESGITIHNVAANENE 264
3_pfamImport 196 FDY----NET--LD---V--LIIPGHRGLLILWSDRSLLYSHNSGQLVDSIPVKRGEQILYrSISQANITIHTIAFNENE 264
5_pfamImport 196 FEY----KGT--LE---V--LITPGQKGILIIWSDDSLLISRNAGQLVNTVVMNLRRYLFYsSISKANLTIHSIAAKKKT 264
XP_023588859 242 FDY----VGT--LD---V--LITPGQKGILILWSDNNLLISPNAGQLINTVMVNFRPYKFFsSILEANLTLHSIATNENE 310
XP_023500280 255 FDY----NGT--LD---I--LITPGQKGILIFWFEKSLLVSWNAGQLVDPVEVKEGRQIVYsSLSEAKVTIHTVAANENE 323
XP_028377724 260 FDY----NGT--LD---I--LIVPGQKGFLIFWFEKSLLASRNAGQLVNPVQVQEGSHTVYsSVFETNITIHSLAANENE 328
XP_020646580 330 IAALTRH-QLFYGSLDMNSNQMVHLGKENSNDT---RepcEVLMFENTGTLSIINPVRSNDSAHYHFEKC 395
4_pfamImport 264 LAILTREnNLYYGSLGILSNSLIKFSDQNLWSQ---Q---SVLMFTDSGKLEILTPLPDKMFAAFDFQKC 327
7_pfamImport 284 IAALTRDhQLFYGSLDMVSTSMVQNGKRNTSQKgicN---AVLMFNKVGMLTLLSLVPSNGTQAYTFWKC 350
2_pfamImport 285 IAALTQDhQLFYGSRDMVSTTMVHIGESNSSQGglcD---AVLMFNRIGMLTMLSPVPINGSWAYNFQKC 351
1_pfamImport 278 IAALTKNqKLFYGTLDMESTQMVYIGDKTKGKP---TdpcEAMMFENIGVLFFVSLIPSMDSALYHFQKC 344
XP_015856278 302 LALLTREnVVYYGSQGYLGTTLVQLPDQPLWSE---E---TGISFTDTGMLEVLTPVADPQFPAFDFQKC 365
XP_017452125 269 LAFLVEQdQLYYGSQSYMGNYIIKLSNQQFWSE---E---ASVHFWDVGMLEVLTPVSDPYFPAFDFKKC 332
6_pfamImport 265 LAVLTKDdRLYYGSLGVLSSSIIKFPDQPIWSE---E---AAMVFLETGMLKILTPLPDTAFQAFDFQKC 328
3_pfamImport 265 LAVLTKEdRLYYGSLRLLSSSIIKFADQPIWSP---G---AAMMFLNPGMLEILTPLPDPASQAFDFRKC 328
5_pfamImport 265 VFLLLAHhCMT--VYSLCPSICLKLSSENVWSR---E---AALMFTHVGKLEILSPLPDLDFPAFDFLRC 326
XP_023588859 311 LAILARNdSVYYGSLSTLSSSVIRLSNQRVWSQ---E---AALMFTHLGELEILTPLPDVNFPAFDFLRC 374
XP_023500280 324 LAVLTQEnHLYYGNLGVLSRSLVKFADQNIWSQ---E---AALMFTNVGMLEILTPLPDSVFLAFDFQKC 387
XP_028377724 329 LAVLTREsNLYYGSLGILTNFMIKFAHQNVWSQ---D---AALMFSNLGMLEILTPIPDSVFPAFDFQKC 392
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