8RHN


Conserved Protein Domain Family
CA109-like
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pfam15011: CA109-like (This model is not part of the current CDD release)
Ribosome biogenesis protein C1orf109-like
Ribosome biogenesis protein C1orf109 is involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. It has been first identified as the downstream target of a protein kinase, casein kinase 2 (CK2) which is upregulated in cancer cells. C1orf109 has been found upregulated in cancer cells and therefore, it has been suggested to be important in the regulation of cancer cell proliferation. The precise mechanism of CK2 targeting C1orf109 is not well characterised. It is found to be localised in the nucleus and cytoplasm.
Links
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Statistics
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PSSM-Id: 521601
Aligned: 28 rows
Threshold Bit Score: 128.542
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8RHN_A        74 ALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLRFEDVp------aLRAFPDLKERLRRKQLVAGDIVLD 147 human
RCV43727       7 KVQQRVRKAREEMDLWDDLNSRLLTNFNRATSVIDRLPVLGEDKNYGA--------LRGVANIQEDLMGKQIESLELIFV 78 
XP_006855714   7 KYQQKYKRVRDQMDTWEDLNSRLLSQFGNASSIIERMQVLQNTKYYGV--------LTCVPGMKKELLGKQMESLESFLR 78 
Q6NPG7         7 KWQQKFRKGKEEMEKWEALQVRWVSLFRNASSIIQRLQEMQNHGSYGA--------LRCLKGIEDAVVQQQMGQLESLLR 78  thale cress
5_pfamImport   1 KWQQKFRKAKEEMNKWEALQVGWVSRFSKASSIIQRLEAIQNPGSYGA--------LRCVKGIEDALLQKQMDQLETTLL 72 
1_pfamImport   1 KYQQKFRKVRDETKRWDELQSRLLSQFRNASSIIERLQSIQNSKNYGT--------LKCIDGIGDAVLRKQMESLETILL 72 
XP_006586169   7 KFQSKFRKVREEMSRWDELQSCLISQFRNASHIVDRLQVLQNSNNYGV--------LNCASGLKDALLVKQIESLRNILV 78 
XP_001418475   7 AFRDAYGALARCRARWDDAQGASVALLGTAVNAFERLPAIHDAARARAvdgseiliDDAF---ASRVVEAQYAALDRVFA 83 
XP_003059506   8 KYRSLYAKARVVLERWSAAQTRATNLVDSVASIYERLAHLSETSRYGPl-------ADSFPDLPARTRDAQYAALDRVLA 80 
XP_004238440   7 KYQQRFRKVKEEMEKWNELQSRLLSQFNNASSIIQRLQILQDSKNYGA--------LTCVEAIQEAVLLKQMNSLQNILL 78 

8RHN_A       148 KLGERLAILLKVRDMVSSHVERVFQIYEQHADTVGIDAVLQPSAVSPSVADMLEWLQDIERHYRKSYLKRKYLLSSIQ-- 225 human
RCV43727      79 SMRETLEKFNGIVKALNKALRDTNQMVRGGSA-LTAKQMQLQVGILPTIAECLDGLRTLCEMHQAEFALKSSIISLLTw- 156
XP_006855714  79 AMKTTLNEFDGIVKALEKLWQDGCQLLKGESKQPTARQMQARIGIRPSLSDCLEGLRAIHEMHHSEYLLKSSIIAAISl- 157
Q6NPG7        79 SMKNVMEEFWGCVLTFEKLHRDGLQLRE---IESSKRRVEERIGVKPCITDCLEGLSILYDMHQSEYHLKSSILSVLScl 155 thale cress
5_pfamImport  73 SMRNDLEEFRGCVLTFEKLRREGSQLLK---MEQTKRRIEERIGVKPCIADCLKGLSLLYEMHQSEYHLKMSILSALScl 149
1_pfamImport  73 SLKKTLKEFHGIVLSLEKIVRDGRQLVKGGSVKLTMKQLQQRIGVKPSLADCLDGLSLLHEMHQSEYLLKSSVVSALStl 152
XP_006586169  79 SMRKTLEEFHCIVLSLDKIHRDSRQQVKGGSCHLNMKQLQQQIGIKPSLIYCLDSLMFIHEIYNSEYLLKSSVISALSei 158
XP_001418475  84 RLREECARFDALTRELERAKTDAWTRTRNLKP-PPKRAGGERSGPQPSIADCVLGLEEAWRMHKDECALKREIVKRAs-- 160
XP_003059506  81 ALEDELELFDDLANLLDKIQRDGSALVRALRP-PPPFAGALRRAHQPSLAECALGLEDVWRAYHDEATLKRVVCDELVvd 159
XP_004238440  79 SMNETMEKFHVVVLSLDKMVRDGRQLIKGGSVQKNVKQLQQHVGMKPSIADCLDGLQLLYEMHQSEYRLKLSVISAISaf 158

8RHN_A       226 --WGDLANIQAL 235 human
RCV43727     157 --KSSSSDIVVL 166
XP_006855714 158 --NSSSADLSAF 167
Q6NPG7       156 ilKPSPGDLNAL 167 thale cress
5_pfamImport 150 alKPSPGDLVAL 161
1_pfamImport 153 tlKPSASDLGAL 164
XP_006586169 159 alKPSDSDLGAL 170
XP_001418475 161 -tCEDAEELKML 171
XP_003059506 160 asVEDVKTMAKL 171
XP_004238440 159 alQPSATDDLAA 170
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