4F5D,6NT6,5CFL


Conserved Protein Domain Family
STING_LBD
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pfam15009: STING_LBD (This model is not part of the current CDD release)
STING ligand-binding domain
Transmembrane protein 173, also known as stimulator of interferon genes protein (STING), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA. It consists of an N-terminal transmembrane (TM) and a C-terminal ligand-binding (LBD) domains. This entry represents the LBD which binds to c-di-GMP. Cyclic dinucleotides induce a conformational change to the STING LBD, leading to high-order oligomerization of STING that is essential for triggering the downstream signalling pathways.
Links
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Statistics
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PSSM-Id: 521599
Aligned: 24 rows
Threshold Bit Score: 182.812
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4F5D_A        31 NVAHGLAWSYYIGYLRLILPE--------LQARIRTYNQHYNNllrGAVSQRLYILLPLDCGVPDNLSMAD----PNIRF 98  human
A7SLZ2       193 NVADGLAWSYYFGYLKFVLPE--------LEKQIEKTSKFRSK---EKFVKKMFILIPSNCFWDDKIPGSDydpqNRITF 261 starlet sea ane...
XP_002061566 145 DYASGMASSYFHGYLNLALPDrsd---dgLQHRMRRYEDSHNV---TFGVHRLIILIPDEMWVGGRIN--S----DLLEP 212
XP_001959984 151 DYAAGMASNYFHGYLKLALPDtkd---dgLKHRMAVYEAKNNV---TFGVDRLIILCPDEMFVEKKLENNS----TLLDK 220
XP_002080818 154 DYAAGMASNYFHGYLKLSLPErkd---dgLKQRMEMYEDKNNV---TFGIKRLVILIPDEMFVNGVLE--S----HLLDK 221
XP_001986375 138 DYAAGMASNYFHGYLKLSLPArng---egLQQRMTDYEDSQNV---KFGLRRLIILVPDEMFVKGLID--S----PLFEK 205
XP_002005921 140 DYAAGMASSYFHGYLKLSLPEren---dgLQKRMEKYEDMQNV---KFGIKRLIILIPDEMFVNRVIQ--S----EWLDK 207
XP_011066563 167 DYGTGMAYNFYYGYLRLTLPSsetg-kkgIIEKIENFEDYHNV---TFPVHKLFLLIPSSGYIPPDLKEASc---QWMEN 239
EFN63910     143 DYGTGMAYSFYYGYLQLILPNrgttdsksIIEKIENFEDKHEV---TFPVHKLFILIPSSGYISPHLKEMSd---QWMEI 216
5CFL_A         3 NVADGLAWSYYFGYLKFVLPE--------LEKQIEKTSKFRSK---EKFVKKMFILIPSNCFWDDKIPGSDydpqNRITF 71  starlet sea ane...

4F5D_A        99 LDKLPQQTADRAGIKDRVYSNSIYEL----LENGQRAGTCVLEYATPLQTLFAMSQYSQAG--FSREDRLEQAKLFCRTL 172 human
A7SLZ2       262 EGNTEPLEKTRGGVFLRHYKHSVYEI----KDGENEPWFCIMEYATPLLTLYDMSVAQPGE--LSREERDAQVVVFLRKL 335 starlet sea ane...
XP_002061566 213 AQPLETININRAGVKGRPYKIAVYRLn---RKINGKYYYFALEGATPMLSFFESIQSNLSAtwYMRELKREIWLKFSAHL 289
XP_001959984 221 AEPLETKYLHRAGVH-RPFKHDVYRLn---KKIDGKTYYFAMEGATPMLSFFDAMESNLSAtwQMKELKREIWLKFCKHL 296
XP_002080818 222 AEPLETQFINRAGVY-RPFKHAVYRMn---KKVNGRTYYFAIEGATPLISFFDAIYSNLSAtwQMQELKREIWLKFYKHL 297
XP_001986375 206 AKPLETHFINRAGVN-RPFKHDVYRLn---RKINNTSYYFAIEGATPMLSFFDAMHHQLSAtwQMQEMKREIWLKFCKHL 281
XP_002005921 208 AEPLETQFINRAGVN-RPFKHAVYRLn---KQINGTTYYFAMEGATPMLTFFESMHFQLSAtwQMQEMKREIWLKFCKHL 283
XP_011066563 240 IHELEEEKRNRAGNIGRTYRNNAYKIypggRKLGNKPIYIVVEGATPLLTYYEVQKHNHPEsaIYKQYKSKIIEKFYTKL 319
EFN63910     217 AGELEEEKRDRAGLRGKTYHNNVYKIypngRNSGASPIYVVAEGATTLLTFYEVQQHSHPEsiVYKQYKNEITMMFYKKL 296
5CFL_A        72 EGNTEPLEKTRGGVFLRHYKHSVYEI----KDGENEPWFCIMEYATPLLTLYDMSVAQPGE--LSREERDAQVVVFLRKL 145 starlet sea ane...

4F5D_A       173 EDILADAPESQNNCRLIAYQEPA-DDSSFsLSQEVLRHLRQEE 214 human
A7SLZ2       336 QDILEGDRACQGKYELVTFSpDRd------LADVMLRKLKDSE 372 starlet sea anemone
XP_002061566 290 KNLLTTWPETRGKVELLMYNSLDdNGNAIdVGELVIAQMEKWN 332
XP_001959984 297 KHLIETWPETRNEVDLLVYNAHDqKGKLVdIGELLIAHLKNKT 339
XP_002080818 298 RELITTWPETRDLIELIIYNSHDsKGNLVdVGELLVANMQNKT 340
XP_001986375 282 KGLLSTWPETRNEVELIFYSAHNsNGEHVdEAEVIINHVFKDK 324
XP_002005921 284 QELLNNWPETRREVQLIIYNSHKqNGELQdVGDVLISHVLTHI 326
XP_011066563 320 QEILQSNPETRDLCELIYYDDFDaQGNKInVATILLERISKIT 362
EFN63910     297 AEILESEPTTKNLCELIYYNDYDsKGTRVnVAKVILQRISEIT 339
5CFL_A       146 QDILEGDRACQGKYELVTFSPDRd------LADVMLRKLKDSE 182 starlet sea anemone
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