Conserved Protein Domain Family
TMEM107
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pfam14995: TMEM107 (This model is not part of the current CDD release)
Transmembrane protein
This family of proteins is found in eukaryotes. Proteins in this family are typically between 138 and 164 amino acids in length. There are two completely conserved residues (H and E) that may be functionally important and four transmembrane helices. The domains in this family vary in length from 124 to 126 amino acids. The precise function of the protein family is still unknown.
Links
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Statistics
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PSSM-Id: 521588
Aligned: 28 rows
Threshold Bit Score: 78.8258
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001302812   8 LFPFRVLAFSAIYITVNVILYTLDSdyggeanivkNYYSArfsnsNLSpnlpdfiksaisrTLSSNEMIADaTTELRIWL 87 
XP_012652285   8 IIPIKFVLIIFHLLVVTITIYSPIQ----------NIYAG-----IPAn-----------tPIGEKSFYTPaFNETQAVG 61 
A0CXY8         7 LIPSKFILVSCHFITSLMAYYGAKE----------NILANfqlktY---------------DTNSDAYTTA-YNSIVSCI 60  Paramecium tetr...
XP_001310398   8 IFPFRVFAFCSLYIVMNVVLFVIDKnesqqanpikNYYANrinnsVANpympdsfknsirgIFSSGKQIKHvQKQIKIWL 87 
XP_045100264   7 TLTKYYQCLLGHFAMATIVIFDQTA----------HLEAS---------------------IIGGIPVAEEaRIGFTVCL 55 
NP_001252431   7 TCTKYFQCLMGHFALSTITIFSQAS----------HLEAS---------------------VSGGASISEEaRIGFTVCL 55 
Q583R6        28 LIPFRIFSILLYLTALICVAGSSDD----------FVLIEsr-----------------dnEVSGGGDRVDlRRSVNVYL 80  Trypanosoma brucei
Q4D1W7        28 LIPFRLLMMVVHFTALVCVSDGSDA----------MIRGGsl-----------------psNYMESEYRFL-RRATDGFL 79  Trypanosoma cruzi
XP_002509302   9 L-PARFITTAAHLIATLTIVYDSSE----------TVKRAl--------------------GSDLSDYSTE-LTSLEGMA 56 
XP_001466968  31 LVPYRLAMWCVHFSTLICVTRGSDR----------MIRVSsl-----------------arGCAEADYVFL-RQVTNLCL 82  Leishmania infa...

XP_001302812  88 IFADIFLVFLFISLIFGIVTTVAHLSFIEGVLHLIGVILMSHALFQNAHRNFVICGVFFGIMLPFLMELWQL 159
XP_012652285  62 SINLLFLIIELCILVFGQNLFYDFFNSLQIFIHFIGAFLTTWYIIEGWNYRSLKYIFGVFTVIPMCLEFFPL 133
A0CXY8        61 IIGMIGLGIEMIFIITGITMFYDTSNFLIICLHAVGIIVYSEFIIGAWPYYELWYYWAAFILLPVLLEIVAT 132 Paramecium tetraurelia
XP_001310398  88 IVSDVLLALVFIFIILGFSTTSAPLSFIEGCLHFIGTVLISNTMLQPASSDYIICGVFFGVMAPFLLEIWEI 159
XP_045100264  56 VLTMLGIIIEFVSIV--LEMPSVVRSLFATSSHTIATCLFLLFIYDAHPVSHFWILLVLLSAPSFFLALLSL 125
NP_001252431  56 VFTKLAILIEFASIL--VDLPSPSRSLYSTLSHTIASIFFLIFIYDSHPPAHFWLLFAFLSLPPCVLAVSAS 125
Q583R6        81 VVSFMLLFVTCWGIFTGRTLRSGTVNFMHCCSHTTAAIALIVIWCLKLHLHRMWHVFYAFGAIPTAMEVCAL 152 Trypanosoma brucei
Q4D1W7        80 AGSFLCLFFNVWGVVTARTLRSGLLNIMHGCFHAAAAVLLIVAWHMQERAERIWHVFYIFSVIPTGLEAIAL 151 Trypanosoma cruzi
XP_002509302  57 YTSIFFFCVEFLGMFTGVSLFMPSANVFYIFAHFFGALFTGLFVTLQWDLQAYPWMFTLFSFFPAFTESVIA 128
XP_001466968  83 ATSFLCLFFNLWGVLTTRTLRFGVDNWFQGSCHCAAAVLLIVSWQATVHVARIWQVFYIFSIIPTGIEAITL 154 Leishmania infantum JPCM5
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