Conserved Protein Domain Family
TEDC1

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pfam14970: TEDC1 (This model is not part of the current CDD release)
Tubulin epsilon and delta complex protein 1
This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex is required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerising microbial metabolite Chivosazole F.
Statistics
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PSSM-Id: 521575
Aligned: 28 rows
Threshold Bit Score: 100.134
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_025049302  48 GYGRSEFYQLPS-DG--SVGSRELLLAFSWLLHRINLLEQL---------LSVNRVKI--RDET-------SLC-Tgdsk 105
PAA89076      93 GFYCRDFDLLPE-DQ--SSGSRELLLAFGWLACKETLLQRF---------ARQLTSPLdfeh-----feqsDSF-Trrqn 154
XP_023931041  86 GFTSVDFNLLPA-DM--STGSRDLLLAFGWLMCKEGIIDKF---------MESCASPLa-eDTIgly---meeL-Gdgvp 148
ELT99332      86 GFFSNDLSHPSS-LA--KCGSRELLLAFAWLLCREDIITRF---------MQKCTSPLqeQDTAflyaqerKFL-Asem- 151
XP_009063110  86 GYLLPDFACLSN-HG--NTGSRELLLALGWLMCQQNILEKF---------MQKCSSPLd-dDTSifyesylDTD-Nkhsa 151
RUS71910      90 GYLSDSFAKLPN-DF--STGSRELLLALGWVIYQQSFINKI---------IKRRSCPLhqDFVKfsksksgILKsPeeqs 157
VDP54840      89 GFPLIRK-NVDE-----SFTSRQLLLGSIWILVSFDVLQKVeqilistafGMTEKIFVhqNEQIftc-pgsNVS------ 155
2_pfamImport   1 GYVSRLG-FYQSgDDvlGLGSRELLLALGWVVLQYDIVERVglmc--vqrLAHPLLPLkePMNGlledtnlLLDgFksqm 77 
PNF21616      76 EYNSIEFYCLPQ-DM--SFGSRELLISVGWLMLTSNVLEIS---------TNRKLRESpmNMEFdvegy----------q 133
KOX78246      82 QYPAIEFYALSE--K--SKNNRPLLLAFAWLLGTQDILNII---------IRINLSNSvlGRECsqln--sveKkEtqyn 146
XP_025049302 106 lgeCgd-----nLL--KSWkgmtelapepglknevD--------IRYLQWLNGRLRFQWRSLHVDYQEQCKLLYKihvyt 170
PAA89076     155 gasQgeapvsglSGdvCND-------------------------LKQLVWLNGKLRMTLKQLQAATKAGASKAQAvaaas 209
XP_023931041 149 dvlDdshlsprsRTdpVRK-------------------------VKQLLWLNGKLRLSLRNLYALQRERAKLMHKlhqst 203
ELT99332     152 ----------petTnpVSR-------------------------VRQLLWLNNKLQLSLRSLYALNREKMSLQHKihgat 196
XP_009063110 152 l------fqssyKIepQAK-------------------------IQKLLMLNGKLQLNLRRMYALQIQDANLSHKihtct 200
RUS71910     158 t------------------------------ksrcDnlmclkekIQYHMMLTGKLRMSLRRLYSTYQQLTSFTYCihqst 207
VDP54840     156 --------------------------------------------IPRLIWLLGRLRIHLKKLYHLKSETMRDFLKlsier 191
2_pfamImport  78 eeiRkemhenslTLs----------------------------sIERLVWLKGRLDKELRTLNRISHTCQKLSTRiseyt 129
PNF21616     134 qsrDvpsqpvfkAGslECT-------------------------LNSILWIAGKIRHNVNSITETCQARVKFATKvhest 188
KOX78246     147 vpeTf-----------NAQ-------------------------INNILYLNGK--------------KAKLVNRihaas 176
XP_025049302 171 ngshmdqtvghf------svtetdlirqpdnykqLMQLLESETSRLEAFLEWKQLE----PVYWQWMETVLD 232
PAA89076     210 ggrrtple--------------lflarhpdmlsrNLQLLERDNERLQCLLRWKDFE----EEFWLWMESVLD 263
XP_023931041 204 ngisldpeknhl------smlevymlrhpellkkNLQLLEKDNIRLQNLLEWKSKE----DIFWKWMESVLD 265
ELT99332     197 sgvsvvpeknhl------smlevfmlrkpellkkNLQLLVKDNERLQNLLKWRENE----DVFWRWMESVLD 258
XP_009063110 201 ngvtlstyrnhl------tpfevrllrypnhlkkMLELLEKDNYRLQNLLLWKEKE----HIFWSWMESVLE 262
RUS71910     208 egvhlqsafnhl------tplevhvlrhpgslkkMLHELEKDNLELTHLLEWKQKE----NVFWEWMGSVLS 269
VDP54840     192 pkllppsh--------------ywvlldpndlrqHIHNVQKSVSKLHLLLSWRDVN----HRFWQWVRSILV 245
2_pfamImport 130 ysskdsplsl----------qdlyflrhgerlkaYLKESETSLMLLKQCHEWSNDGgrarTVVSNWFNSVLE 191
PNF21616     189 inccglphls---------vsetklvrypellpvYLDRISEYVVLMDTHKQWLKKC----HVFWEWMETVVA 247
KOX78246     177 vnvsglphlsvseaalikrvsttnknalsnedkiYIKELSTIASLLDVHMKWSKKK----HVFFEWMVTVVQ 244
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