Conserved Protein Domain Family
BRI3BP
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pfam14965: BRI3BP (This model is not part of the current CDD release)
Negative regulator of p53/TP53
This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumourigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumour suppressor. BRI3BP induces tumourigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumours.
Links
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Statistics
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PSSM-Id: 521571
Aligned: 12 rows
Threshold Bit Score: 156.724
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003796088  52 TVNTFSQSVSSLFGEDNVRAAQKFLTRLTERFVLGVDMFMETLWKVWTELLDVLGLDVSNlsqYFSPASVANSPARALLL 131
Q28GF3        39 AATGFYQTVNNVFGEENVRAVQKFFSRLTERFVYGVDVLVETLWRIWTDLLEVLGIDASNlthYFSPAAVANNPTRVLML 118 tropical clawed...
4_pfamImport   1 AANGLYQTLSSIFGEDNIRALHKFFSKTTERFVYGVDAFLDTIWKIWTDLLDVLGIDSSNltyYFSQTALTSSPARTLLL 80 
NP_001082804  38 AASGFYQTLSNVFGEENIRALYKFFSKTTERFVHGVDSLLDTLWKLWVDLLDVMGIDSSNlthYFSPSSVSSSPARALLL 117
3_pfamImport   1 LCEDGHGFLVSLFGRQSVDSGLKTLREITTWALESTAGSLNILASYVTEVLGAAGITAN-----LPVKRITPEGVAFVTK 75 
NP_001139031  44 LSEEAHSFLVSTIGEKRVDLSLKFLQSGVKWLSDAVASALNVAIRYITEILESAGIDAK-----LPFQKVTPEGVIFVTQ 118
XP_006010221  47 TGRAVLEGLEQVLGKELLQRALEFLTSCSEVIADGLSAGLRTLYRFANDGLRALGVEGER---FTHFLNLSSQEVHTLLI 123
XP_005046602 115 MGRTTWDTLENWVGPQLLQMVAESLSTTLWIVSSGISAALTTLCGILGDLLAASSISGHR---LVRAAALAPREVQRVLL 191
1_pfamImport   1 MSRAIRKTVEDLIGRDNFQILSENLSSLLWIVSSGISSALLVVARVSGQFLTSFGLAGDH---LTQFLKRSPDEVQTLLL 77 
XP_003993469  53 IGRSVRGTLEAWLGPETIHLVSETLSQVMWAISSAISVAFFALSGIAAQLLNALGLDGDH---LTQGLKLSPSQVQTFLL 129
XP_005988983  34 AAQGLYRGLCSVFGEENIGALQRFFSKITDQFVCGMDVLVETLYRIWTDLLDVLGVDASNlthYFSPTAVTSNPTRAVLL 113
XP_003970428  60 TYREIQRYAESAMGIGVIRSAVEFLEMVIRFLAEGAASGLNVIAVYLTEILRVTGFNVA-----VTLPLFTPEGVTAIAQ 134 torafugu

XP_003796088 132 VGVV-LLAYWFLSLTLGFTFSILhlvfGRFFWIVRVVLFSMSCVYILHKYEGEPENAVLPLCFVVAVYFMTGPMGFYWRS 210
Q28GF3       119 VVAI-LLAYWFASLLLGFFFYLLhivfGRFFWLVRVSLFALSCIYILQKYEGEPEHAMIPLCFVVAVYFMTGPVGLYWRR 197 tropical clawed...
4_pfamImport  81 VASV-VVAYWLLSLFLGGLFYLLqvafGRFFWLVRVVLFALSCLYILQKFEGDPERAVLPLCFVMAVYFMTGPVGSYWRK 159
NP_001082804 118 VAAL-LVAYWFLSLFLSGFFYILhavfGRFFWLARVTLFALSCLYILQKFEGDPEKAVLPLCFIMAVYFMTGPVGAYWRK 196
3_pfamImport  76 WVLLaVLVYWILSLAVCFVSGIV----QRTLWLVKITVAIAMFGLILSDTGATAETTAMRLAGLMLACILLGIGPSPFKG 151
NP_001139031 119 WAILaVLAYWILSFILRLVVGAV----RQALWLLKLSFAVGTFGLILSDSGASAETTALRLAGLACVCVLLGIGTASAKS 194
XP_006010221 124 WGAVaLIGYWLFSFLLHLILSVV----GRVFWLLKIGLFLSAFVYIITAYEDP-ARRATLLLVLLVVYVLLGRFC---SS 195
XP_005046602 192 WAVAaLLGSWVLSRLRRLLLPLL--------HWLKLFLFLCAFLHVAASQESP-TVQAGMLLGLWVLYALLGSL----VA 258
1_pfamImport  78 WGLAaLIGYWLLSLVLSLLVAIL----SRIMWGLKVVLFVACFMFIVSSVPDR-SVQTLLLLALLTLYVLLGWL----SG 148
XP_003993469 130 WGAGaLVVYWLLSLLLGLVLALL----GRILWGLKLVLFLAGFVALVRSVPDP-STRALLLLALLTLYALLSRL----TG 200
XP_005988983 114 VGAV-LLAYWFLALFIGVLFSLLhavfGRMFWIVRVILFALSCLYILQKHEGNPEQAVLPLCFVVAVYFMTGPVALYRRR 192
XP_003970428 135 WGLLaLFGYWVLTMLLHLVICVV----KRVFWVVKTVLVLWLFGLIVTDKNANADTTAVRLWGLVLGCVLLNLL----KS 206 torafugu

XP_003796088 211 Np-SNPNVEEKLEHLENQVRLLNIRLN 236
Q28GF3       198 S--SNNNLEDKIDHLDNQIRLLNIRLT 222 tropical clawed frog
4_pfamImport 160 G---GSSLEDKIDHLDGQIRLLNIRLS 183
NP_001082804 197 Gg-GSGTLEEKIDQLDTQIRLLNIRLS 222
3_pfamImport 152 D--TNTHMEVKVKVLERKVRELEKKSK 176
NP_001139031 195 D----AHLENKVKMLERRLKEMEKSKM 217
XP_006010221 196 SesEVHYLRDRVRSLEGEVNNINRNME 222
XP_005046602 259 SpdPSARLDAAVRNLEWKVEELRRRQK 285
1_pfamImport 149 ShnSGTRLEAKIRGLERQVEELQRRQR 175
XP_003993469 201 TraSGAQLEAKVRGLERQVEELRWRQR 227
XP_005988983 193 N---SSTLEDKIDHLEGQIRILNIRLS 216
XP_003970428 207 DseKTCSMDNRLRNLEGRLKAVEKRKG 233 torafugu
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