Conserved Protein Domain Family
AIF-MLS
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pfam14962: AIF-MLS (This model is not part of the current CDD release)
Mitochondria Localisation Sequence
This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localisation sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.
Links
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Statistics
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PSSM-Id: 521568
Aligned: 10 rows
Threshold Bit Score: 193.924
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001103026   6 AVSKTLALPRRAPPGPAPLGKDASLRRVSSSKFPGPSGSNMIYYLVVGVTVSAGGYYTYKAFTSKQVRHTEHVTDPKEQT 85 
XP_004768551   1 MYLRRAVSKTLALPLRAPPGPAPLRKDASLRWMSSNKWFGSSGSNMIYYLVVGVTVSAGGYYTYRTITSEQGKQTERVTN 80 
A6QLZ1         1 MYLRRAVSKTLALPLRAPPGPAPLRKDASLRWISSNKFPGSSGSNMIYYLVVGVTVSAGGYYTYKRVTSGKAKRSDHVTD 80  domestic cattle
2_pfamImport   1 CTSAGPVSRSLALPLRAPPSPAPLRKDASLRWMSSNKSPGSSGSNMIYYLVVGVTVSAGGYYTYRTVTSEQVKHTGHIKN 80 
3_pfamImport   1 MYLRRVVSKTLALPLRAPPGSTPFRKDASLHRLSSNKLPGSSGSNLMYYLVVGVTVSAGGYYTYKAVRSEQARHTEHTTN 80 
XP_006144687   1 MYLRRAVSRTLALPLRAPPSAAPLGKDASLRRMSSSKFPGPSGSNMIYYLVVGVTVSAGGYYTYKAVASEPAKHTEHVTT 80 
XP_005327629   1 MYLRRVVSKTLALPLRAPPNPAPLGKDASLRWMSSNKFPGTSGSNMIYYLVVGVTVSAGGYYTYKTVTSKQAKHTEHITN 80 
ELK17444       1 MYLRRAVSKTLALPLRAPPSPAPLGKDASLRWMSSNKFPGSSGSNMLYYLVVGVTVSAGGYYTYRTVTSEQARHTEHITN 80 
4_pfamImport   1 MYLRRAVSKTLALPLRAPPSPAPLGKDASLRRMSSNKFPGSSGSNMIYYLLVGVTVSAGGYYTYKTVTSDQAKHTEHITN 80 
Q8TDB4         1 MYLRRAVSKTLALPLRAPPNPAPLGKDASLRRMSSNRFPGSSGSNMIYYLVVGVTVSAGGYYAYKTVTSDQAKHTEHKTN 80  human

NP_001103026  86 KAELQPLPGETEHVAEAGKACSETGEISVKESDSVDAEEVPEAAAVLPEESQ-ASASEVPAEaaLVETSVLSSEPELKIT 164
XP_004768551  81 LKEKNKAELHPLQGEKENVAGAEKASSDVCEVSAPEVLEVDAEGTPDVPAAA-VEEASAGPG--DVEATAGEPDAVSAKV 157
A6QLZ1        81 LKEKTKAELQPPQGEKENLVGAEEASLEAPEVSSTEASPVVTEDIPDAPAVV-GKEAPPCPD--DAEAAPSETVVVGAEP 157 domestic cattle
2_pfamImport  81 LKEENKAELQPLQVEKENLEGAEKASSEAPEVSSEEAQVVDAEESSDAAAAGrAEEASACPD--AAEAAPVEITAVGAET 158
3_pfamImport  81 LKENNKAELYSLQGEEENAVEAERASAEAPEVSVVEAEVVGTEEVPSATDAV-IEEDLACPE--GGNAALVGKAAVGAET 157
XP_006144687  81 LKEKTKAELHPLQGVKGNVEEAEQAGFEVPEVSAVAAEVEGAEGLPGATAES-TPEDRPCPG--GVEAP-----AAGVEP 152
XP_005327629  81 LKEKTKAELHPLQGEKENVAEAEKASSEALEVSVVQAEVVGAEEIAEAAVG--DVEESAGPG--DVEATKEEVTAVGAEM 156
ELK17444      81 LKEKTKAELQQLEGEKENLGGAEKASSEAPEVSSVEAQVVDAEEIPDATVAV-ITEASACPD--TAEAAPVETTAVSAET 157
4_pfamImport  81 MKEKTKAELHPLQGEKEHIAEAEKASPEAPEVSVVEAEVVAAEEIPDATVAA-LTEASACPG--GVEAAP-ETAASGAET 156
Q8TDB4        81 LKEKTKAEIHPFQGEKENVAETEKASSEAPEELIVEAEVVDAEESPSATVVV-IKEASACPG--HVEAAP-ETTAVSAET 156 human

NP_001103026 165 DDHDAspvETTEGVPE-SPPEVEGAAPDQADVCSEGVDD 202
XP_004768551 158 GAEAT---DAGLGATA-EASAEAPPEVQSAALDGAVAGN 192
A6QLZ1       158 KPEMT---DAATVETT-EVSTETTSEVTSTGPEEAAAVD 192 domestic cattle
2_pfamImport 159 EPEVP---NVTPCESA-QVSTGATSEVTSAAPDEAVAIS 193
3_pfamImport 158 GLEGT---DAPTGETT-KVDAEATQGVTEAAPYEAVAHS 192
XP_006144687 153 ASEGT---DTATGETT-EVDSEESPEVPSAAPGDAVAIR 187
XP_005327629 157 EPKVT---SAQTGDTT-EDGSEMTPEATDVAASEGISTC 191
ELK17444     158 GPEVP---NAATGETA-EVSIQTTSEVTNAALDEAVAID 192
4_pfamImport 157 APEVP---EAVVGDTTeEVSAGTTPEVTDPTLGEAVAID 192
Q8TDB4       157 GPEVT---DAAARETT-EVNPETTPEVTNAALDEAVTID 191 human
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