Conserved Protein Domain Family
BROMI

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pfam14961: BROMI (This model is not part of the current CDD release)
Broad-minded protein central region
The Broad-minded family proteins are essential for the proper response to Sonic hedgehog (Shh) signaling during neural tube development. Members of the Broad-minded family collaborate with cyclin-dependent kinase 20 (CDK20) to regulate the structure of the primary cilium. They are involved in the coordination of the ciliary membrane and axoneme assembly, which is crucial for the activation of the GLI2 transcription factor in response to Shh signaling. This entry represents a central series of alpha-solenoid repeats.
Statistics
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PSSM-Id: 521567
Aligned: 7 rows
Threshold Bit Score: 1074.78
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006005873  173 EQLQVIAERLDPSQPKEMRQEALQTLCCAPPSDVLNCESWITLRKNLTVALSDPDSALSDKILRFYAKTFSSSPLNITRE 252 
4_pfamImport    1 EQLQAIAEKIDSSQPKEVRWEALQTLCCAPPSDVLSCESWTGLRRNLSAALGDPDPAFSDKVLKFYAKTFSSSPLNITRE 80  
Q5RHR6        173 EQLQVIAEKLDPGRPREVRWEALQSLCHAPPSDVLSCESWTGLRRNLSTALTDPDPELSDKVLQFFAKTFSSSPLNVTKD 252  zebrafish
3_pfamImport    1 EQLQVLAEKLDSNKPKEVRWEALKVLCRAPTSDVLSCESWSSLRRNLCVALSEPDPDLSDNALRFFAKSLSSSPLNVTRE 80  
XP_004940317  173 EQLQLLVEKLDPIQPKEVRQEALQMLCLSPPSDVLNSECWPNLRKHLMMSLSDPDAIFSEKILRFYAKTFSSSPFNMARE 252 
2_pfamImport    1 GKLQLIVDQLDPRQPKEVRHEALQMLCSAPPSDILGCENGASLCQRLTAALSDPDPVLSDRILKFYAQAFILLPLHMTNE 80  
XP_018668106  172 EQFHCIADEMDCRKPIDIRRDALTRLCHVPPSDVMASESWSQLRVSLMDALADPDPFLSHTTLSFHAKMFAVSNYQIMRE 251  vase tunicate
XP_006005873  253 IYTSL--AKHLESYFLSSGSQIpTLHSGVDITDPDIARLLKKVRLLNDFQKEASSFWIRHPEKYMEEIVESTLSLLSVTH 330 
4_pfamImport   81 IYTSL--AKHLESVFLSQKTSF-STAAGLDISNQDVARLLKKMRLLNEFQKEVTSFWIRNPEKYMEEIIESTLSLLSLNL 157 
Q5RHR6        253 IYASIgnTKTLEAHFLYHKLSFpSGTTSIDANRPDMARLLKQMRLMNDFQKEVTTFWIRHPEKYMEEIIENTLSLLALHS 332  zebrafish
3_pfamImport   81 IYTSL--AKSVASSFLSHKLSFpSGSATIDINRPEISRLLKQIRLMNDFQKEVTNFWIRHPEKYMEEVIESTFSLLSYHH 158 
XP_004940317  253 VYTSL--AQHLEFYFFSGEYSL-RISSGLDVSNADVNHILKKVRLLNEYQKEAPSSWIRYPEKYMEEIVESTLSLLSVKH 329 
2_pfamImport   81 IYTSL--AKYLELYFLSRESHIpTLSAGVDVNNPDVTRLLKKVRLLSEYQKEAPSFWIRHPEKYMEEIVESTLSLLSAEH 158 
XP_018668106  252 TYTCL--AEHLIRWFKSSSQSLpSIYEPLDITKSEVVLLIKRIRLLNEFQCEVPSIWVRYPESFLEVIVDSSLSLLCLQL 329  vase tunicate
XP_006005873  331 EQALRTDTAHKALDPVYFMAMLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIAVSVQQCFDYFGSCNPEADDITKIST 410 
4_pfamImport  158 DQSLKTTSADKVLEPIYFLSMLDIKANWFKKWMHGYYSRTVVLRLLENKYKSLIVASLQQCINYYESCESSCDKTSNIAH 237 
Q5RHR6        333 EQGMSSPGSEKSLEPIHLISLLDIKATWFKKWMHGYYSRTVVLRLLERKYKSLIVNALQQCIYYFDSCDALSEETLEMIH 412  zebrafish
3_pfamImport  159 EHG--SPGTERVLEPVHLLALLDVKATWFKKWMHGYYSRAVILRLLERKYKSVAVAALQQCIKYNESCERFTNETTE--- 233 
XP_004940317  330 DPN--HPASPDFLSPIYFLALLDIKAMWFKKWTHAHYSRTVILRLLEKKYKSLINAAVQQCLDYFEYCKAAVSKTPRVSG 407 
2_pfamImport  159 APG--PLLSPKILDPICFFALVDTKAVWFKKWTHAYYSRTTVLKLLEKKYKSLIIAAVQQCIQYLELCETSKADLI---- 232 
XP_018668106  330 KLGKNSNNSDK-LTALHFLSLIDIRANWFRKWLHGNYSRATLINSLEGKYQPVLQDAVLQCLTF---CRDSLSKPK---- 401  vase tunicate
XP_006005873  411 LMHQQYISNKHRTY-YTGRELNYIYFVHSLCLLGRLLMYTHGRKLFPVKVKNRKEMVSLMDILVLLIRIIYWNPRSTQKR 489 
4_pfamImport  238 VRQQQQTGTTQRMF-YTARQLEYTYFVHSVCLLGRLLMYTHGRKLFPIKLKRRKDPVTLTDLIVILIRIMYRHPIPYYSE 316 
Q5RHR6        413 SLEHQQIGPAGRTL-YTSKELEFVYFVHSLCVLGRLVMYTNGRKFFPIKVKKRRDPVTLTDLVVILINIMYQHPKPSCGE 491  zebrafish
3_pfamImport  234 SGEQRSIGLVQRSV-YSGKELEYCCFVHSLCVLGKLVIYTNGRKLFPIKIRKYKDPVTLTDLIVILLNIMFKHPRPLDRD 312 
XP_004940317  408 FSQ-QHLNNEQKFF-YTGSELQYIYFVHSLCLLGRLLIYKQGRNLFPVHLENKKDCISLTDLLVLFARLIYYSP-SYSKE 484 
2_pfamImport  233 LGHSKHCGDKQKTLyYSGQEVQYIYFIHSLCLLGRLLIYTQGRKLFPIKLKNRHDSVSLTDLVVLFIRLIYYSP-SHPDT 311 
XP_018668106  402 -SHPHHTPQDGRRTtYTPNEIRYARFVHSLCFVSRLLFYTGGRELFPVSIDIFPHPISVQHLLISWIQLI-----GLAKS 475  vase tunicate
XP_006005873  490 LT-AQTDIYTPATLVMEVLQMLCDRKECATECLYNSTVLDSLLFPISSLLKGKRAKSN-YNETTLTYIADILARIASTEG 567 
4_pfamImport  317 IPhVVVDSLSPACLVMDVLRTLCDRKECAVECLYAIAVIELLLSPIIALLKGKQVNLT-SPETTLTHIADILARIATTER 395 
Q5RHR6        492 T--ALADTMSPTNLVMEVLRTLCDRTECAVECLYQIPVIETLLAPLITLLTGKLPKLN-SMESALTHTADTLARIATTER 568  zebrafish
3_pfamImport  313 CShTGSDVVSPSTLVMEVLWMLCEQTEWAAECLYQTPVIEKLLAPVIALLNGQKAELK-SPAATLSLIADILARIANTDR 391 
XP_004940317  485 ALtAHTDNYSPASLVMEILQVFCDQTGCAADCLYTDAVMDALLDPLQSLLNGTEVYIN-CLETTLIDVADILARIAAAED 563 
2_pfamImport  312 TPdVDSEDYSPASMVTEILQILCDQKECAMECLYSSTVISTLLQPIHNLMKGNEAAPH-CSETALIHAAGVLARIASAEE 390 
XP_018668106  476 KPkHGHKAYEPASLVCKAICNLCLSNAFVEQCV-GDEVISVLLIPIRTWL---EPSSKrYSESCMLHIAEILACLTSTCA 551  vase tunicate
XP_006005873  568 GLILLLYGETTKSPEKQSFSAAHIIAQFTKKLLDEEIP--ALSESETFP--SLKGTFLFVCRQMYNTCEGLHVLISYGLH 643 
4_pfamImport  396 GLSLFLYDGNFIYTEGEGISAAHVIVQFTKKLLADKIS--VLSEAGPLT--SLKGAFIFVCRQMYNTCEGLQVLKPYGLH 471 
Q5RHR6        569 GLSLLLYDRNLVSAEGESISAAHLIVQFTQKLLAKELQ--VENSS------SMSGAFIFVCRQMYNTCEGLQVLRPYSLH 640  zebrafish
3_pfamImport  392 GLALFLFEKNLAAAHSERTFAAHIIVQFTQRLLDKELP--SLCESDMPH--SLCGAFILVCRQMYNTCEGLQVLRPYGLH 467 
XP_004940317  564 GLPVLLYGGSKNSAKESSPTAVHVIVQFTKKLLHDDIS--LLSGSELLQ--VVKGAFIFVCRQMYRTCEGLQMLIPYGLH 639 
2_pfamImport  391 GLALLLYGEDMSPSEEDSLTGAHVTAQFTKRLLEGEVP--GLAGSALLP--AVQRAFVSLCCQMCGTCEGLQALLPYSLH 466 
XP_018668106  552 GRKLLLHG----SGSEKKSAAAHVIAEFAQKSLNSKLPsgTLQSAGNIPsySVVGAFVFVCRQMYNVCEGLLLLLEYNLH 627  vase tunicate
XP_006005873  644 ESIAEAWKKASLF---SERIPTPVAGa----DSSASVAPE-LQNMVVWEETLLDNLLNFAATPKGMLLLQQTGAINECVT 715 
4_pfamImport  472 DCIAEAWKQTVSL---SERVPTPVPG-----DCSSSATQD-SQNNMVWEETLLDNLLNFAATPKGLLLLQQTGAINECVT 542 
Q5RHR6        641 ECIAQAWRTTSSM---SERVPTPVPGa-----PPALASQE-LQSVVAWEEMLLDNLLNFAATPKGLLLLQQTGAINECVT 711  zebrafish
3_pfamImport  468 KALAAAWKKTSTL---SERVQTPVPGg----DAGSS-TQE-LQNMLIWEETLLDSLLNFAATPKGLLLLQQTGAINECVS 538 
XP_004940317  640 ESIGEAWKKASLL---SERVPTPVTGa----DCTSSISLD-SKNVLLWEETLLDALLNFSATPKGLFLLHSTGAMSDCVS 711 
2_pfamImport  467 EAVAQARRKASLP---SEGIPTPVLGs----HSVSSVSQG-SQNIMAWEESLLDDLLNFAATPKGLLLLHRAGVINDCVT 538 
XP_018668106  628 QGIAAAWKQAHEKwgdSHAVPLKFDDsneniDEQSSPTQSsSRNLVLWEETLLDNLLNFAATPKGLLLLQQTGAINECVA 707  vase tunicate
XP_006005873  716 YMFSRFTKKLQVSRCEKFGYGVMVTQVAATSPGAVALQCSGFINALVMELWSVLEWGRDDVRVVHPKSTPMDPIDRSCQK 795 
4_pfamImport  543 YMFSRFTKKLQVSRCEKFGYGVMVTQVAATAPGVAAIWSSGFVQAIVLELWSVLECGRDEVRMIHPKSTPMDPIDRSCQK 622 
Q5RHR6        712 YMFSRFTKKLQVSRCEKFGYGVMVTQVATTAPGIVALQSSGFVQTIVVELWSALECGREDVRVVHPKSTPMDPIDRSCLK 791  zebrafish
3_pfamImport  539 YMFSRFTKKLQVSSCEKFGYGVMVTQVAATAPGVVALHSSGFIRALVLELWSVLECSGDNIRVVRPKPTPIDPIDRSCLK 618 
XP_004940317  712 FMFNSLSKKHQTNEREEFGNGVIVAQMATTPTAAVALQSSGFIKAFITELWALLECGKDDVRITQPKSTPVDPIDQSCQK 791 
2_pfamImport  539 FMSNQYAENLQVSRQKKVGYGVLVTQVASTAAGAAVLRDSGFVSALVAGLWSSLECGGEDTMVNHPRPTPVEPIDRSCQK 618 
XP_018668106  708 YMHSRYTKKLQVSKCEKFGYGVMVTQVAATAAGTSALYKAGFLRAIIHELWSHLEHATDEIRMTAPRPFPLHPIDRSVHK 787  vase tunicate
XP_006005873  796 SFLALVNLLSSYQAVYELLGNQELPNKTEYSLREVPTSIIDVMDRLVIMNSDAKIHS 852 
4_pfamImport  623 SFLALVNLLSSYSAVYELLVKQELPNKPEYPLREMPTSIIDLIDRLIIINSEAKIHS 679 
Q5RHR6        792 SFLSLVNLLSSPHAVWELLGHRALPNKTEYNLREMATSVLDLMDRLIIINSDAKIHS 848  zebrafish
3_pfamImport  619 SFLYLVNLLSSSQSVWELLGRQPLANKSEYTLREMPTSIPDLIDRLIAMNSDVKIHS 675 
XP_004940317  792 SFLYLINLL-TYPAVFELLSEQDIPNKPMYSHREVPTDIINVIDRIIIVNSEAKIHS 847 
2_pfamImport  619 SFLALVSLL-SSPAGYELLGLQDLPNRAEYSLHELPTCVTDIIDRLIILNSEAKIHS 674 
XP_018668106  788 SFMGLVNVLSSYPAVHELFYQQQLPNKTSYTFREMPESPINLIDRLVMINSEAKIHA 844  vase tunicate
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