Conserved Protein Domain Family
DUF4504

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pfam14953: DUF4504 (This model is not part of the current CDD release)
Domain of unknown function (DUF4504)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 253 and 329 amino acids in length. There are two conserved sequence motifs: LLGYP and SFS.
Statistics
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PSSM-Id: 521560
Aligned: 21 rows
Threshold Bit Score: 211.751
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002533364  14 DSSLSHI--KWRLKSHAKHRLQIDVLALCTEMRPVIMVDY-GGKMPELQEHLCALlrlcqQESP-I-------------- 75 
CBI36690      14 STSLSRT--KWRLKASSKRRLEIDILALCTGMRPVVMVDY-GGKMPELQERLCAVlklsqKASS-I-------------- 75 
XP_006858895  14 ENSIFRV--QWRLRAASKRRLILDVLALCTGLRPVVMVDY-GGKVPELQERLCSVlnlvhKESS-F-------------- 75 
4_pfamImport   1 RGTTSRN--KLKCHAE----LLADIMFLCTRLRPVVLMDY-GGTMPELQENLCSLlhharQETS-I-------------- 58 
XP_003576730  18 EACAARI--RWRLRPQSKRRLLNDILFLCAGLRSVILMDY-GGTMPLLQENLCSLlhhaqQEAS-I-------------- 79 
XP_020147922  18 EACAARI--RWRLRPQSKRRLLNDITFLCTGLRPVILMDY-GGTMPQLQENLCSLlhharQEAS-I-------------- 79 
XP_002681017  26 FNINVSKigSTTNKKQNNYSLGRDLFHLWSGLRDTILLDY-----AVLKDSDCTDlqnlsKQLSiLennnsellnnfpht 100
XP_015462602  15 FLCCGNK--KKRLSSLSCLDVAVQILAVDLGLKPAFLYDCnAASAEQLLQYLNSL-----QDAGlL-------------- 73 
Q567C3        14 QKCLCSR--KKRLSPSSCLEVTIHIIAVDLGVKPALLYDSnGASPDQLQLYLHSL-----QESSvV-------------- 72  zebrafish
NP_001118858  14 SSCLSQI--KWRLKSNSKRRLEIDVLALCTGMRPVVMIDY-GGKMPELQNRLLSLlelirEGLP-V-------------- 75 
XP_002533364  76 ---------FEHLKVMII----------EDMI--YLIHVKGLVEYVKSSLNsEVDLVFVNLEQDPPKMVTQAENSSLNAA 134
CBI36690      76 ---------FYHLRIMVI----------EDMI--YLIHVKELAEHVRSSLNsEPELHFVDLEHNPPKMIVQAEKSSVAMQ 134
XP_006858895  76 ---------FLPLRVMII----------EEMV--YLVHIEGFSQHVLSSLSlQWQLQFVDLDQDPPKIISYQGQNSVASQ 134
4_pfamImport  59 ---------LSPLRVMVI----------KDML--YLIHAKGLAEHASPNARsQHQLAFVDLGKSCTKLLPDTEENDNVHE 117
XP_003576730  80 ---------LNPLRVMVI----------KDML--YLIHVKGLAEHVSPNARsRHQPAFVDLEKSCCELLVNTEENGTVLE 138
XP_020147922  80 ---------LNPLRVMVM----------KDML--YLIHAEGLAEHVSPNARsQHQLAFVDLEKSCCELLANTEKNETMVE 138
XP_002681017 101 shenvnklnFGNIGVMIIkfwmffdgkrEEMIfnYLINTEKLKQRLEKLQScDLNLIFIDIDALDRKEPYLECGEKIQNN 180
XP_015462602  74 ---------TTILQVVSI----------DGNN--LVVNSELMKSHLAELIS-ERRIITVDVCPWKEQPAICDMESRSVEM 131
Q567C3        73 ---------SNSLRIMSI----------NDNT--FIINPDIMKSHLGELLK-SKSLPLIDVCSSRKRPVLCAFERSAEEM 130 zebrafish
NP_001118858  76 ---------FKDLKVMVI----------EDMI--YLINVRSLPKFVSSSLDsEPELFFIDLEQDPPKMVTQSKESNLGMQ 134
XP_002533364 135 LVRVQKLFSLYLPVNenvspchltetaanasdnvanaadsvanaadsvasaessinkpiISQSSEFIDFSSCMQDSEVTV 214
CBI36690     135 LISVQKWFSLLFPVDeinndllpsitte------------------vmsiakpsisepvASQSSEIIDLSSGIQGTQVAV 196
XP_006858895 135 LIAVQNLFSVAFSSEgtnnlfmga---------------------------tpsrdvlvPSQPSQCIDLSSCLENSKVVI 187
4_pfamImport 118 FVSIQDLFSAKFPVDaaleipegtt-------------------------dtdcsgsctADRISLVIDLTASIE-SALAL 171
XP_003576730 139 LLSIQDGFSGKFPLEaafepgttkqeskl----------------aekataveytdihvANRTSLVLDLSAILENTQIAL 202
XP_020147922 139 LLSIQDRFAATFPLEadvepettqqksrl----------------peratdvertgisiPDTTSLVVDLSAFLEGTQMAL 202
XP_002681017 181 IQPFIQLISNQIIENfn----------------------------------------ngNGKCVFEIDFSSHLTPSLPFL 220
XP_015462602 132 IKAISELFLNKADKD-------------------------------------------------SSVCMLPEQMYDQWNL 162
Q567C3       131 VRSFLEVFMNGLD-----------------------------------------------------LVVLEEELYKDWNL 157 zebrafish
NP_001118858 135 LRSIQKLFSSTFPLDdsntdtt------------------------------tvldeanSSQTSLCIDLSCCLQDTKVTI 184
XP_002533364 215 P----TLNGWLLGYPVVYL----FSKEHIADaiYNLS------TKYLRIFQILVSRNISPNKASr-pEELMSFSVPYELS 279
CBI36690     197 P----TLNGWLLGYPVVYL----FSTEHISDaiFNLS------TKSLRIFKILICRNDAYKGSGk--EELLSFSVPYDLS 260
XP_006858895 188 P----TLNGWLLGYPVVYL----FSKEHTSHavCNLS------TRPLHIFKILVCRKGASARENsqeEELMSFTVPYELS 253
4_pfamImport 172 P----SLNGWLLGYPVIYL----FCNGSAEIatQNLS------KHSLHIYRIYAVRHRPSAAKQs-eQELMSFSVPIDMS 236
XP_003576730 203 P----SLNGWLLGYPVTYL----FRNESAEAatQNLS------KHSLHIYRIYVVRSPHSDAKPs-eEELLSFSVPCEMS 267
XP_020147922 203 P----SLNGWLLGYPVTYL----FRNESGETatQNLS------KHSLHIYRIYVVRNRHSDSKQs-eEELLSFSVPCDIS 267
XP_002681017 221 PfdatLMNGILLNYPIILFygsrFPIQQTSN--KNLKfyanhvLNNIDLYRYTLSCTQEHQ------ETLLQFIIPQSIY 292
XP_015462602 163 C----TLFGIILGYPATYW----FDQSQNFE--NCLK------MTPLVVYKVWVCWEAGDKKHC---SCLYSFSVPEILW 223
Q567C3       158 C----TFFGILLGYPASYW----FEQTQGFE--NCLS------MTPLVVCTVWVRWQIHEIKQR---CCLYSFSVPEELW 218 zebrafish
NP_001118858 185 P----TLNGWLLDYPVVYL----FGTDHIEEaiYNLS------TKSLRLFKVLVCRNGTTEKDSh-lEELTSFSVPYDLS 249
XP_002533364 280 ------MGGSKEPWAEAFLAQMQSRwekskQIWRTLQMEVSECYPQAiVL 323
CBI36690     261 ------MGGSNEPWAKAFMAHLEAKwekckQVWSSLQMEESDLATYS-RW 303
XP_006858895 254 ------TGGRNEAWAQEFLTHMLLKiakckNIWRHLRMEVIECSPQSiAL 297
4_pfamImport 237 ------TKRDEEPWAKSFLCYMNEKikqcnHVWASIWMEIEVFQSQSgLV 280
XP_003576730 268 ------VRRDEEPWAKSFLACMNEKlercnHVWASMRLEIDVFRSQSgVI 311
XP_020147922 268 ------MKREEEPWAKSFLARVNGKlercsQVWASVRLEIEVFQSQSgVI 311
XP_002681017 293 sensqmIDSTIEQWLSTQQQSNKKP---------HLQLSKETIQYDNiVL 333
XP_015462602 224 s----eVHAYIQQWTELLSDRFSKQ-----KVLTELSFSQETVVLPSvAL 264
Q567C3       219 s----dVQSHIQRWTDHLRERFSKQ-----TVLTDICFSRDTVTLPSvTL 259 zebrafish
NP_001118858 250 ------MEGSKEVWAEKFLERMSSRweeckHIWRSLDLQVSECYPQAiVL 293
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