Conserved Protein Domain Family
TCRP1
?
pfam14944: TCRP1 (This model is not part of the current CDD release)
Tongue Cancer Chemotherapy Resistant Protein 1
This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumor cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.
Links
?
Statistics
?
PSSM-Id: 494693
Aligned: 7 rows
Threshold Bit Score: 189.047
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
NP_001232126   1 MNPVYSPVQPGAPYGNPKNMAY-TGYPTGYPTAAPAYNPNMYPTSSPGYAPAtllmkqawpqtssscategtf------- 72 
5_pfamImport   1 MNPVYSPVQPGTPYGNPKNMAF-TAYPGGYPATAPTYTPNLYQTGSPGYPPG---------------------------- 51 
1_pfamImport   1 MNPVYSPVQPGTPYGNPKNMAF-TGYPGGYPATAPTYTPNLYQTGSPGYPPAfsflfwrllkfafknrwdgsmcgqq--- 76 
3_pfamImport   1 MNPVYSHAPSGVPYANPKGISYpAGFPVGYAAAAPAYSPNIYPGANPAFQTGhqaeeslfeavlrgwnyhnndrscw--- 77 
6_pfamImport   1 MNPVYSPAPTGVPYPNSKGIGYpAGFPVGYAAAAPAYSPNMYPGASTAFQTAsqgytsspagplrvhetacvlwdswssp 80 
4_pfamImport   1 MNPVYSPASTGVPFTNTKGMGYpAGFPVGYAAAAPAYTPGVYAGANQAFPSG---------------------------- 52 
2_pfamImport   1 MNPLYSPVQPGTPYGNPKNMAF-TGYPGAYPATAPTYTPNIYQTGSPGYPPG---------------------------- 51 

NP_001232126  73 --------------hlpvdtgtenrtyqassaafrYTA-GTPYKVPPTQSNNAPPPYSPSPNPYQTAMYPIRSAYPQQNL 137
5_pfamImport  52 -----------------------------------YTPaGTPYKVPPTQSNGAPPPYTPTPTPYPTAMYPIRSAYPQQNI 96 
1_pfamImport  77 ----------gvihlfvplslcerrafisssaatrYTSaGTPYKVPPTQSNGAPPPYTPTPTPYPTAMYPIRSAYPQQNL 146
3_pfamImport  78 ----------qavlsfkmdqltkrrtepsssdsfcYTP-GTPYKMSCSPTSGTVPPYSSSPNPYQTTVYPVRSPYPQQNP 146
6_pfamImport  81 aknlaltlsgqydltctwskksqntdfrsqmlefwYTP-GTPYKV--SPTTGAVPPYSSSPNPYQAAVYPVRSAYPQQNP 157
4_pfamImport  53 -----------------------------------YAP-ATPFKVSCSPNTGTVPAFSSSPSPYPAAVYPLRGTYPQQSP 96 
2_pfamImport  52 -----------------------------------YTSaGTPYKVSPTQSNGAPPPYTPTPTPYPTAMYPIRSAYPQQNI 96 

NP_001232126 138 YT--QGAYYTQPVYAAQPHVIHHTTVVQPNSIPS-AIYPAPVA--APRTNGV-AMGMVAGTTMAMSA--GTLLTTPQHTA 209
5_pfamImport  97 YA--QGAYYTQPVYAAQPHVIHHTTVVQPNSIPStALYPAPVPvpAPRNNGMpTMGMVAGTTMAMSA--GTLLTTPQHPP 172
1_pfamImport 147 YA--QGAYYTQPVYAAQPHVIHHTTVVQPNSIPStALYPAPVPvnAPRNNGMaAMGMVAGTTMAMSA--GTLLTTPQHAQ 222
3_pfamImport 147 YAq-QGTYYTQPLYG--PHVIHHTTVVQPNGMPA-AMYPPAIP--PPRANSV-TMGMLAGTTMALSAvlGTLLT-HSPTP 218
6_pfamImport 158 YAq-QGTYYTQPLYATPPHVIHHTTVVQPNGMPA-AMYAPPIP--PPRANGV-TMGMVAGTTMAMSA--GTLLTTHSPTP 230
4_pfamImport  97 YAqqQGAYYTQPLYAAPPHVIHHTTVVQPNGMPA-AMYAPHIP--PNRHSGV-AMGMVAGATMAMSA--GTLLASPSPAP 170
2_pfamImport  97 YA--QGAYYTQPVYAAQPHVIHHTTVVQPNSIPStALYPAPVPvpAPRNNGMaAMGMVAGTTMAMSA--GTLLTTPQHPQ 172

NP_001232126 210 IGAHPVSVPTYRAQGTPTYSYVPPHW 235
5_pfamImport 173 IGAHPVTVPTYRPQGTPGYSYVPPHW 198
1_pfamImport 223 IGGHPVTVPTYRPQGTPGYSYVPPHW 248
3_pfamImport 219 VAPHAVTMPTYRPPGTPTYSYVPTQW 244
6_pfamImport 231 VAPHPVTMPTYRPPGTPTYSYVPPQW 256
4_pfamImport 171 VTPHPVSVPTYRPPGTPSYSYVPPQW 196
2_pfamImport 173 IGAHQVTVPTYRPQGTPGYSYVPPHW 198
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap