Conserved Protein Domain Family
TCRP1
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pfam14944: TCRP1 (This model is not part of the current CDD release)
Tongue Cancer Chemotherapy Resistant Protein 1
This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.
Links
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Statistics
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PSSM-Id: 521555
Aligned: 7 rows
Threshold Bit Score: 197.537
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001232126   1 MNPVYSPVQPGAPYGNPKNMAY-TGYPTGYPTAAPAYNPNMYPTSSPGYAPATL-----------LMKQAWPQTSSSCAT 68 
1_pfamImport   1 MNPVYSPVQPGTPYGNPKNMAF-TGYPGGYPATAPTYTPNLYQTGSPGYPPAFSflf------wrLLKFAFKNRWDGSMC 73 
3_pfamImport   1 MNPVYSHAPSGVPYANPKGISYpAGFPVGYAAAAPAYSPNIYPGANPAFQTGHQae-------esLFEAVLRGWNYHNND 73 
6_pfamImport   1 MNPVYSPAPTGVPYPNSKGIGYpAGFPVGYAAAAPAYSPNMYPGASTAFQTASQgytsspagplrVHETACVLWDSWSSP 80 
XP_029699230  29 MNPVYSPVQPGTPYGNPKNMAF-PGYPGGYPATTPTYTPNLYQTGSPGYPPG---------------------------- 79  torafugu
XP_003967860   1 MNPIYSPASSGVPFTNTKGLGYpAGFPVGYAAAAPPYTPGVYAGANQAFPSG---------------------------- 52  torafugu
XP_029699229  29 MNPVYSPVQPGTPYGNPKNMAF-PGYPGGYPATTPTYTPNLYQTGSPGYPPG---------------------------- 79  torafugu

NP_001232126  69 EGT--------FHLPVDTGTENRTYQASSAAF--RYTA-GTPYKVPPTQSNNAPPPYSPSPNPYQTAMYPIRSAYPQQNL 137
1_pfamImport  74 GQQgv-----iHLFVPLSLCERRAFISSSAAT--RYTSaGTPYKVPPTQSNGAPPPYTPTPTPYPTAMYPIRSAYPQQNL 146
3_pfamImport  74 RSCwq----avLSFKMDQLTKRRTEPSSSDSF--CYTP-GTPYKMSCSPTSGTVPPYSSSPNPYQTTVYPVRSPYPQQNP 146
6_pfamImport  81 AKNlaltlsgqYDLTCTWSKKSQNTDFRSQMLefWYTP-GTPYKV--SPTTGAVPPYSSSPNPYQAAVYPVRSAYPQQNP 157
XP_029699230  80 -----------------------------------YTSaGTPYKVPPTQSNGAPPPYTPTPTPYPTPMYPIRSAYPQQNI 124 torafugu
XP_003967860  53 -----------------------------------YAP-GTPFKMSCSPNTGTVPPFSSSPNPYPAAVYPVRSTYHQQNP 96  torafugu
XP_029699229  80 -----------------------------------YTSaGTPYKVPPTQSNGAPPPYTPTPTPYPTPMYPIRSAYPQQNI 124 torafugu

NP_001232126 138 YT--------QGAYYTQPVYAAQPHVIHHTTVVQPNSIPS-AIYPAPVA--APRTNGV-AMGMVAGTTMAMSA--GTLLT 203
1_pfamImport 147 YA--------QGAYYTQPVYAAQPHVIHHTTVVQPNSIPStALYPAPVPvnAPRNNGMaAMGMVAGTTMAMSA--GTLLT 216
3_pfamImport 147 YAq-------QGTYYTQPLYG--PHVIHHTTVVQPNGMPA-AMYPPAIP--PPRANSV-TMGMLAGTTMALSAvlGTLLT 213
6_pfamImport 158 YAq-------QGTYYTQPLYATPPHVIHHTTVVQPNGMPA-AMYAPPIP--PPRANGV-TMGMVAGTTMAMSA--GTLLT 224
XP_029699230 125 YA--------QGAYYTQPVYAAQPHVIHHTTVVQPNSIPStALYPAPVPvpTPRNNSIpAMGMVAGATMAMSA--GTLLT 194 torafugu
XP_003967860  97 YAqalipsqqQGTYYTQPLYAAPPHVIHHTTVVQPNGMPA-AMYAPHIP--PTRHNGV-AMGMVAGTTMAMSA--GTLLT 170 torafugu
XP_029699229 125 YA--------QGAYYTQPVYAAQPHVIHHTTVVQPNSIPStALYPAPVPvpTPRNNSIpAMGMVAGATMAMSA--GTLLT 194 torafugu

NP_001232126 204 TPQHTAIGAHPVSVPTYRAQGTPTYSYVPPHW 235
1_pfamImport 217 TPQHAQIGGHPVTVPTYRPQGTPGYSYVPPHW 248
3_pfamImport 214 -HSPTPVAPHAVTMPTYRPPGTPTYSYVPTQW 244
6_pfamImport 225 THSPTPVAPHPVTMPTYRPPGTPTYSYVPPQW 256
XP_029699230 195 TPQHPQIGGHPVTVPTYRPQGTPGYSYVPPHW 226 torafugu
XP_003967860 171 TPSPASVTPHQVTMPTYRPPGTPSYSYVPPQW 202 torafugu
XP_029699229 195 TPQHPQIGGHPVTVPTYRPQGTPGYSYVPPHW 226 torafugu
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