Conserved Protein Domain Family
Muted

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pfam14942: Muted (This model is not part of the current CDD release)
Organelle biogenesis, Muted-like protein
The protein is a coiled-coil protein and belongs to a family found in eukaryotes. It undergoes alternative splicing forming two isoforms. The larger isoform is 187 amino acids long in protein sequence length and 21 kDa in mass. The smaller isoform is 110 amino acids long in protein sequence length and 12 kDa in mass. This protein associates with other proteins in order to form biogenesis of lysosome-related organelles complex-1 BLOC1 complex. BLOC-1 is required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system.
Statistics
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PSSM-Id: 521553
Aligned: 27 rows
Threshold Bit Score: 106.212
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEC20157             11 VKDIGEVHSRLFDHKPFLQGEIKyfikefeEKRNDREVQRLFEILENVTEIRETQIDRICRNs------DQKLCNLT--G 82 
7_pfamImport          1 IKDCGEIWNRLFDHRPFLNGEIK-------ESRGDREISRLFEIHELVTDFRDTQIPKTCEK-------ENTLNKLN--V 64 
2_pfamImport          1 FKDLSDIWDRLFSHRPFLQGEIKyflsefdKKSYRADEENLKKISELVSDLKEKKIERFLQSs------GENLFLLN--S 72 
WGS:AAPU:GI10477-PA  17 GRELYKVPHRILDHRVFINGEIDifldnfeLKRNDSEVETLFQVTEIVGSLKYDLSERCIALg------NQRLTELS--T 88 
XP_001954048          6 GRELYKVPLRILDHRVFVNGEIEsfldnfeTRRNDSEVEKLFQVTETVGSLKYDLSDRCIASg------SQHLTQLG--S 77 
XP_002433201         30 FKDIGEIWTRLFDHRPFLNGEIRfilqefeEKRGNKEVERLFAILQNITEIKYNQIDSIKLKa------DENLETLQ--N 101
XP_003288334         19 IRDIGTVYEFYFDQNTFVENEVKtflkefeTKRGDRDIISLSQQTFNANATMAIINKSLSLSkqhlssiNTTLSETN--K 96 
Q54TC6               17 IRDIGTVYEFYFDQNTFIESEIKtflkefeTKRGDRDLYSLSQQTINANNTIVNINRSIHQSsqfleniNNNLNQIN--S 94  Dictyost...
A7SPE8                7 VRDISGVYARLFDHRAVLQAECKymlrefeGKRNDRELERLRESEQKIRQVQEE-IPKCITE-------SVKLKDLL--E 76  starlet ...
XP_009022670          9 TPSASDVYHRLFDHRAAIQGEINyfldiveEK--DDGLVRMKSMRNTLNNLDKNVFPSLMNSl------ELHMKSLNdsS 80 
EEC20157             83 NLEVALSMCNKILEA--EDKINVAEDLSERR---KQRQCEWEKFMQDIKDKTARMDEAFQQKEREVIDHFRCLQEKL 154
7_pfamImport         65 LLDISLQNCAIVNEN--KEKYSQNQTLEAKR---ALRKTEWENFMKDIRCKYSNIDKTFKEKEDELKEFYDDLEKKL 136
2_pfamImport         73 AINEALNLSQAILDQ--ENNIISEEDLKTKEefhERRQRELETFKSDLKTRYESIDKDIEDKVEAIKIHFEEDINKL 147
WGS:AAPU:GI10477-PA  89 AVNNLLNGVETLLEKa-KVERKPSVELQEAR---RAREQRKAEFLSNLQHNYKRIDNSFEEKEEEIAELYSDLQLKL 161
XP_001954048         78 EVNQLLEGVNDLLAKa-KVERTASTQLQEAR---LAREKRRAEFLTNLEHGYRRIENSFEEKEEEIAELYSDLQLKL 150
XP_002433201        102 KIDDSLVVCNTILQE--EEQYRTDTTILKNK---ERRKAEWDVFIKDISQKCVKIDEEFNVKEKDLRDYYADLDNIT 173
XP_003288334         97 R------INEQLLKEnsHQEQRDTDRINKHQielMERKNVEDNY----NKRKEEIEREFNEKASQLRDKYQ---IVL 160
Q54TC6               95 K------LSTQVENEsiHQEQRNNDRLNKFElelVEKKSIEDSF----NQRKSQIENDFNEKASVLRDKYQ---IVL 158 Dictyosteli...
A7SPE8               77 ELKVAREKCHEILVK--EEQDLFKERREEIF---IESKKNWETFIGEIAEEEKRIEEEFEQSAEKLRARYGVQLVRN 148 starlet sea...
XP_009022670         81 KIVGLTNDVDHLMTEvdKIDYEKISNIEN-----VKSESRMLLFEKEIAVKKENIDEEYNKELEKCKSYYDQ-QEKI 151
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