Conserved Protein Domain Family
OAF_N
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pfam14941: OAF_N (This model is not part of the current CDD release)
Out at first
This entry represents the N-terminal BRICHOS-like domain (pfam04089) found in OAF protein family. The gene, OAF (out at first), which encodes this protein, has a promoter which may help mediate regulation of neighbouring genes. An alternative name for this protein is HCV NS5A-transactivated protein 13 target protein 2, which stands for Hepatitis C virus nonstructural 5A-transactivated protein 13 target protein 2. NS5A inhibits double-stranded-RNA-activated protein kinase (PKR) activity, which is thought to allow Hepatitis C Virus replication to continue in the presence of an alpha interferon (IFN)induced antiviral response.
Links
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Statistics
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PSSM-Id: 521552
Aligned: 15 rows
Threshold Bit Score: 232.202
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_011256501  23 THLLINVKNQGGDILLETISSNVTEDLITLEFQRSDGTLVTQLIDFKNEVQVIKALVLGEEER----GQNQ--YQVMCFV 96 
XP_001603817  24 TNLLINVKNQGGDILQETITSNITEDVITLEFQRSDGTLVTQLVDFKNEVQVIKALVLGEEER----GQNQ--FQIMCFV 97 
2_pfamImport   1 SCLVVNVKDQDGSVIKEIIYANITDDTITLELQLPDSTLITQHIDFTKEVQIVQVLLLGEEER----GQKP--YQILCFV 74 
XP_009016418  19 SQLIINAKNKGGDVFKEFIEANTTYDTISLDFMTADGTLVTHFVDSKNELQIFKLSLLPEDDL----FQTG--VINFCFV 92 
XP_027419273  42 SELRVRVRLPDGQVTEESLQADSDADSISLELRKPDGTLISFTADFKKDVKIFRALILGELEK----GQSQ--FQALCFV 115
Q71SY6        27 AELRVRVRLPGGQVTEESLQADSGSDCISLELRKADGALITLTADFRQEVKIFRALILGELER----GQSQ--FQALCFV 100 chicken
XP_700455     31 SELKVRVRLTDGQITDELLEADSEKDSITVEFKQGDGTLITFVADFKQDVKIFRALILGELER----GQSQ--YQALCFI 104
XP_032515558  21 LQLLINVKNQGGDVMQENITANVSEDTVTLEFLRLDGIYVSQLVDFTNEVEAMKIVIPAEEEL----GQTG--HQILCFL 94 
EDW25374      83 AQLLINVQNQGGEVIQESITSNIGEDLITLEFQKTDGTLITQVIDFRNEVQILKALVLGEEER----GQSQ--YQVMCFA 156
XP_046454442  34 PQLVINIKNQGGDVLQEVLASNVSEDVVQLEYQRADGTIVTQMLDFRKEVQIYRLLILAEEEQlplkSFQPpyYQAVCFA 113 common water flea

XP_011256501  97 NHFYKVDFISSDAMSKLRQKNPGTVRVAEEDRGHVNYTMDLFLDVSQSKEISKHVATLCTEAAGSTYTRNDDIKQW 172
XP_001603817  98 NHFYKMDFISSDAMSKLRQKNPGTIRTAEEDKGHANYTMDLFLDVSQSSVVSKHISDICSEAADSTFTRYEDIKHW 173
2_pfamImport  75 NHVHANEFISPDAMSKLRQKNPGTIRVAEENKGVFNITIDMKIKSKDSNYISQHVGSLCSEAQDTTFTSKVDIDKW 150
XP_009016418  93 TRITKNEFISSDAMSKLRQKNPSAMRHPEEQLPTSIYTMDVMLNARASHLLSPHINSLCKTAKYSTFAEQADIKLL 168
XP_027419273 116 TRLHHNEIIPSEAMAKLRQKNPRAVRQAEEVRGPEQMHMDIAVNFSQGALLSPHLRNVCAEAVDAIYTRQEDVRFW 191
Q71SY6       101 TRLHRNEIIPSESMAKLRQKNPRTVRQAEEVRGLEHLSMDVAVNFSKGAQLSSHIHNVCAEAKEAIYTREEDVKFW 176 chicken
XP_700455    105 TRLNHNEIIPSESMARLRQKNPQAIRTAEEKRGTEMLSMNVAVNLTRTWQLSAHIHNMCSVAHEAVYTREADVRHW 180
XP_032515558  95 THAAQADFIAPDAMAKLRQKNPGTVRVAEEDKGWRQTTTTAWAGCA-TRLLSPAAARHCSAARDRVYLRTADLTRW 169
EDW25374     157 TKFNKGDFISSAAMAKLRQKNPHTIRTPEEDKGRETYTMSSWVQLNRSLPITRHLQTICAEAMDATYVRDVDLKSW 232
XP_046454442 114 AKLSKQDFIAADAIAKLRQKNPHTVRYPEEDNGRENATFEYTLDVSRSNIISNQIQQLCINA-TAIYVQETDLRLW 188 common water flea
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