Conserved Protein Domain Family
TMEM138
?
pfam14935: TMEM138 
Transmembrane protein 138
This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells. Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.
Links
?
Statistics
?
PSSM-Id: 494685
Aligned: 20 rows
Threshold Bit Score: 105.019
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_001962712  82 AILFFVIQDVLIIAEYVLFTFTLHSTCVHQVGASHIILRNCKLFLVSVTIYFLLSASQHFWIVSQYRLAPGNETteWPL- 160
XP_011402877  40 lsVVYALQDFFLVLSFILTFLIFFNTFTFTSGLITILLKKFSWSLCTGVAYLLVTIAYQIWSLNNRWNNRWV----WSA- 114
1_pfamImport   1 SILLFVLQDIGQLVAIAVLLITFFQTNIFQAGFIVLLFNEFRSTIITGVGYFILTLFVQVWTLTNRFKGQVYFY--WPD- 77 
2_pfamImport   1 VIFLFIAQDVCLMLSFTAFVFSLYSTYVYQAGMANLLYEKFRTPLLISMTYFFLSIALHLWQVLGHSNEPYQFQ--WPK- 77 
XP_001869684  40 IIFLFLAQDVCLILSFTAIIFSLYSTYVYQAGMAHLLYEKFRVPLLVAMMYFILCISLHTWQVVDHHKSPYLFQ--WPK- 116
XP_032512706  38 LLVLFIFQDLFLILSITMMLMTFFSTYLFQAGLVEVLIRKFRAAGSVIVSYLAASVLLHTAWLMQKWSDPES-V--STP- 113
XP_002425851  38 QLVAFIFQDVFIVISLTVTLIGFFSTYVFQAGLVELLFDRFRLAILISVFYFIITIILHAWLLTIRWNNPNNFN--WTD- 114
EFN66129      40 LLVLYVIQDFCLIAALTLLLVNFFSTYIFQAGLIQLLYTRFRITLILCIIYMILSISLHTWHITIHWSSPLKHY--WTK- 116
4_pfamImport   1 LFVVFIVQDAFLLMAVTCLCFSLFRTNVFKAGFVELLLYGFKGTIIFAALYIILTVSLQTFLLLLRWEQPIDYN--WPG- 77 
XP_002126014  37 QLVLFILQDICLVFQLVVLCLEIFNTATSQAGFISVMMKKFAPCLLTTLLYLVLSIALCAKTLMLRWNDTTVNV--YADg 114

XP_001962712 161 GLIALSVIQRIVSVFYYYSCKSTALTMADPRFKeEYVDWIVEQ 203
XP_011402877 115 GLQFMYVLHKMVALFYYYIYKRGLYRLSDPKLYlPNSNWVSDr 157
1_pfamImport  78 GLYVFFVLHKFTSCLHYYLYKRTALCISDPKFY-TD-EWINH- 117
2_pfamImport  78 ALTALFIIHRLFSPIYYYLYKKSALKMSDPRFY-ENLDWIASQ 119
XP_001869684 117 ALTALFIIQRLFSPLYYYLYKRSALKMSDPRFY-ENLDWITSa 158
XP_032512706 114 FLIVLFTFQRCLSPWYYFFYKRAALRVSDPRFY-EDIDWISQQ 155
XP_002425851 115 GLTIFFSCQRMFSPIYYYSTKRAMLRISDPRFY-QSLDWISRh 156
EFN66129     117 GFHILYSIHRTVAVLYYYFYKRASLRIGDPRFY-KGSIWVQKQ 158
4_pfamImport  78 LLSALYIIQRFFAVLFYYFYKRSSLRLSDHRFY--DEEWVKHT 118
XP_002126014 115 GFFAVYILQRLWSPIYYYTYKRTAMRLADSNFY-KNTDWLRRQ 156
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap