Conserved Protein Domain Family
TMEM138

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pfam14935: TMEM138 (This model is not part of the current CDD release)
Transmembrane protein 138
This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells. Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.
Statistics
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PSSM-Id: 494685
Aligned: 20 rows
Threshold Bit Score: 105.019
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001962712  82 AILFFVIQDVLIIAEYVLFTFTLHSTCVHQVGASHIILRNCKLFLVSVTIYFLLSASQHFWIVSQYR-LAPGNETteWPL 160
XP_002900824  48 dsivsFVQVLLQIAALVNLLLLLGGTFLFRSGLFGMLYSHFRLVLLVHLLYICLTIILGIVRMNLLSpGNEHVDI--WDA 125
XP_011402877  40 lsVVYALQDFFLVLSFILTFLIFFNTFTFTSGLITILLKKFSWSLCTGVAYLLVTIAYQIWSLNNRW-NNRWV----WSA 114
1_pfamImport   1 SILLFVLQDIGQLVAIAVLLITFFQTNIFQAGFIVLLFNEFRSTIITGVGYFILTLFVQVWTLTNRF-KGQVYFY--WPD 77 
XP_001238150  40 VIFLFIAQDVCLMLSFTAFVFSLYSTYVYQAGMANLLYEKFRTPLLISMTYFFLSIALHLWQVLGHS-NEPYQFQ--WPK 116
XP_001869684  40 IIFLFLAQDVCLILSFTAIIFSLYSTYVYQAGMAHLLYEKFRVPLLVAMMYFILCISLHTWQVVDHH-KSPYLFQ--WPK 116
XP_032512706  38 LLVLFIFQDLFLILSITMMLMTFFSTYLFQAGLVEVLIRKFRAAGSVIVSYLAASVLLHTAWLMQKW-SDPES-V--STP 113
XP_002425851  38 QLVAFIFQDVFIVISLTVTLIGFFSTYVFQAGLVELLFDRFRLAILISVFYFIITIILHAWLLTIRW-NNPNNFN--WTD 114
XP_011259707  40 LLVLYVIQDFCLIAALTLLLVNFFSTYIFQAGLIQLLYTRFRITLILCIIYMILSISLHTWHITIHW-SSPLKHY--WTK 116
2_pfamImport   1 LFVVFIVQDAFLLMAVTCLCFSLFRTNVFKAGFVELLLYGFKGTIIFAALYIILTVSLQTFLLLLRW-EQPIDYN--WPG 77 
XP_001962712 161 -GLIALSVIQRIVSVFYYYSCKSTALTMADPRFKeEYVDWIVEQ 203
XP_002900824 126 rGYAAFSGIHKIGALCYYACSIVAVEKLRKHKYY-SPEYWMRr- 167
XP_011402877 115 -GLQFMYVLHKMVALFYYYIYKRGLYRLSDPKLYlPNSNWVSDr 157
1_pfamImport  78 -GLYVFFVLHKFTSCLHYYLYKRTALCISDPKFY-TD-EWINH- 117
XP_001238150 117 -ALTALFIIHRLFSPIYYYLYKKSALKMSDPRFY-ENLDWIASQ 158
XP_001869684 117 -ALTALFIIQRLFSPLYYYLYKRSALKMSDPRFY-ENLDWITSa 158
XP_032512706 114 -FLIVLFTFQRCLSPWYYFFYKRAALRVSDPRFY-EDIDWISQQ 155
XP_002425851 115 -GLTIFFSCQRMFSPIYYYSTKRAMLRISDPRFY-QSLDWISRh 156
XP_011259707 117 -GFHILYSIHRTVAVLYYYFYKRASLRIGDPRFY-KGSIWVQKQ 158
2_pfamImport  78 -LLSALYIIQRFFAVLFYYFYKRSSLRLSDHRFY--DEEWVKHT 118
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