7SQK


Conserved Protein Domain Family
HAUS-augmin3

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pfam14932: HAUS-augmin3 (This model is not part of the current CDD release)
HAUS augmin-like complex subunit 3
This domain is subunit three of the augmin complex found from Drosophila to humans. The HAUS-augmin complex is made up of eight subunits. The augmin complex interacts with gamma-TuRC, and attenuation of this interaction severely impairs spindle MT generation. Furthermore, we provide evidence that human augmin plays critical and non-redundant roles in the kinetochore-MT attachment and also central spindle formation during anaphase in human cells.The HAUS complex is required for mitotic spindle assembly and for maintenance of centrosome integrity.
Statistics
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PSSM-Id: 521546
Aligned: 38 rows
Threshold Bit Score: 169.81
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7SQK_C        29 WLFEG-VEDESFLKWFCGNVNEQNVLSERELEAFSILQKsGKpILEGAALDEALKTCKtsdlktp--------------r 93  human
XP_049548291  23 WVVHD-ENFRDFFDWFAK-VDDDNLITDALDKDYDELKRhDD-VYEESEVDALLKQLDtqysnileytdrdvteleqqle 99 
XP_002025926  22 WLLYD-EKLEKFFKYLSVSITDSNILTEQEVLERDEMQHrAN-WLTGSELQLKQQEIEaenpgllthtqqdvdalsavga 99 
XP_001991893  22 WIIYD-ERFEKFFQFLFKNISDSNILTDHELLARDEMMQhGE-WLNETERQLKLQQIEaewpgllehtdedlealsaeie 99 
XP_002055549  23 WIVYD-EQFEKFFNFLSENVTDSNILTARELLERDEMMQrGE-WLQESERILKLQQIEsenpgllkytnqdvetlaaave 100
XP_002010566  22 WIIYD-EQFEKFFNFLSENITDSNILTEREVLESEEMKQrGA-WLKESERVLKLQQIEsenpgllkytahdvdalaleve 99 
XP_001959134  22 WILYD-EQLEKFFKFLSQDVTDANILTESQVLEREEMRRrNE-WLEESDRELKLLQIEsespgllkfnrqdvsgltmeia 99 
Q9W2P0        22 WILYD-EQMEMFFKFLSGNITDANILTERQVLEREEMQRrGE-WLSASDRELKLLQIEaespgllnykqqdvdaltmsie 99  fruit fly
Q6ZLF7        28 WPFLQgDDARRLLAWVSSRLRPANVLSATDLALYEQLELeGK-LLEGEDLDFAFDSISafsetgenqedtf--lteesle 104 Japanese rice
XP_002459453  28 WAFLQgEDSRRMLAWVGARLRPGNVLSATDLELYEQLEMeGK-LLEGEDLDFAFDRISafsdngenqdyif--lteesle 104
7SQK_C        94 lddkeLEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEV 173 human
XP_049548291 100 qmveiEEHYERLLEDAKKTDILLTKELTDIERATIDAQYLMEKQEKSCLTLGKRLEENQLITQQKIADLHHCYLQPQN-- 177
XP_002025926 100 aiqeaSADYASLIENMANTKQTINNNLIELECAASALQNTEKILLSDCQEKAKQLEELQSENCKLSSEAKKAFISEPM-- 177
XP_001991893 100 qlqqaTNDYNVLIDEMKNTKHSININLSELEYEIRPLQVAERELLGECQKKAGQLEQLQRHNRELVEETSREFTMQQM-- 177
XP_002055549 101 vieeaTNDYSTLIDEMQNTKHSIISKLSELESTILLLHNTEREMLVECQAKARQLEELQRENCKLSEDTNKGFTLPQV-- 178
XP_002010566 100 aikeaTKDYCILIDEMQNTKHSQSSKLSELECTILSLSNGERELLGECQAKARLLEEVQRENAKLSEEANKGFTMQQS-- 177
XP_001959134 100 sieeaSRDYALLLEDMLNAKHSITNHLSELECAACELQSKEKELLSECQSKAKQLEELQRENCRLSGEAKKSFTTPQM-- 177
Q9W2P0       100 aiedaSRDYATLLEDMMTTKHSITKHLGEVECVTAELQLREKDLIAECQSKAKQLEELQQENCRLSAEAKKAFTAPQL-- 177 fruit fly
Q6ZLF7       105 hirdsKLTLRAEVSDLERQLASLEWQLDMLTAQATTITQGKKSRVSAKTNPNIQISRLDEKLAKRSLEMNSLLGKLAATT 184 Japanese rice
XP_002459453 105 diresKLALRAEVSDLEKQLASLEWKLDILTAQATTINQGKKSRSSANTRANGQLTGLDEIFAKRSLEMNAILGKLTATT 184
7SQK_C       174 TQLMMFFRHSnlgqgtNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFqlldiqtpsicDNQE 253 human
XP_049548291 178 -----------------PPLFVYQMPIEQFDAKCDQFLKYLQMYVKKHFP--VRHLEGFK----------------SSTE 222
XP_002025926 178 -----------------PQLFMHQLPLEHYFLKCDSFMQYFTLYIKENFK--IQKNNEF-----------------STAE 221
XP_001991893 178 -----------------PPLFMHQLPLDQYFLKCDSFLQYFTLYMKDNFK--IQEYAEF-----------------ESID 221
XP_002055549 179 -----------------PPLFMHQMPLDQYFLKCDSFMQYFTLYMKENFK--IQELIDF-----------------ESAE 222
XP_002010566 178 -----------------PPLFMHQMPLEQYFLKCDSFMQYFTLYMKENFK--IQEFTEF-----------------EDAE 221
XP_001959134 178 -----------------PPLFMHQLPLEQYFLKCDSFMQYFTLYVKENFK--IQEYDEF-----------------QIAE 221
Q9W2P0       178 -----------------PPLFMHQLPLEQYFHKCDSFMQYFTLYVKENFK--IQDYDEF-----------------QSAE 221 fruit fly
Q6ZLF7       185 QELSYYHSEA------DIGIYLSYSDFQSYIIQNLACIKELNRWFSKKFEKGPLQFVAKEDMSRG-----------DYEG 247 Japanese rice
XP_002459453 185 QELSYYHSDA------DTGVYLSYCDFQPYVSSVLACTKELNKWFSKKFEKGPLQLVVQDDKIRG-----------DSVN 247
7SQK_C       254 I-LEERRLEMARLQLAYICAQHQLIHLKA 281 human
XP_049548291 223 LsNSEVLDELEDIKLRLDVEELKLLEEKR 251
XP_002025926 222 VnILHEKEKLESLERGIQYYALAFIKKKA 250
XP_001991893 222 VdIQQMNSKLENLQNSMEYYTLAYIKKKA 250
XP_002055549 223 VdVQHFNSKLENLQNSIQYYTLEYIKEKA 251
XP_002010566 222 VnMQHFNSNLENLQKSIQYHTLEYIKEKA 250
XP_001959134 222 NdFLHEKHKLEDLQNGIQHYALSYIRHKA 250
Q9W2P0       222 EdLGREKAKLEDLERGIQFYALSYIRTKA 250 fruit fly
Q6ZLF7       248 S--HHLSVELKRINSIFARSKRQYIEAQA 274 Japanese rice
XP_002459453 248 S--NHFVVELSRINSIFAKSKRQYIEAQV 274
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