Conserved Protein Domain Family
HPHLAWLY

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pfam14925: HPHLAWLY 
Domain of unknown function
Members of this family carry two distinct, highly conserved sequence motifs, CPPPLYYTHL and HPHLAWLY. The family is found in eukaryotes, and the function is not known. This family lies at the C-terminus of members.
Statistics
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PSSM-Id: 464381
Aligned: 7 rows
Threshold Bit Score: 889.262
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELK05079     197 CSDASGVRSASPPNQDVTELDMETNTFCPPPLYYTHLTQEKRPPAQGKITIKPQMNIPEEL-SGTLPEETLVNP--PTHT 273 
XP_012665365 276 CPNAKGGRCFSPRDEEVTELDIETNTFCPPPLYYTHLTQEKPPPAQVKITIEPQVKLPEEL-DGAFPEKQCINS--PTHR 352 
Q9P2G4       273 CSGAGNGRNVSSLNEEVTELDMETNIFCPPPLYYTNLTQEKPPPAQAKITIEPQMNAPEEM-DDASPEKKRVNP--PAHR 349  human
XP_007651539 243 CSPALSGRTVSPLSPEVTELDFETNIFCPPPLYYTHLTQEKTPPDRVEITIEPQRNGPEEL-DGILPETKLVGP--PIH- 318 
A3KMW7       279 CSKGSSERSVSPPNQEGTEVELETNIICPPPLYYTHLTQEKTPPKQGKITIEPQINASEEWdDGTFLKEN-VNP--PTHT 355  domestic cattle
2_pfamImport   1 CSNASSRKCNSPLNQEVTELDIETNTFCPPPLYYTHLTQEKRPPTWGKMTFVPQVNMPEEL-DGVFQEEKLVNP--PTCI 77  
XP_001378915 304 MGLNEVRENINATNQEVTELELETNIICPPPLYYSHLEPKKVPPAKGRFITVPQISVPKES-DDVVQEEIAPCPmvRNHE 382  gray short-tai...
ELK05079     274 HSLKHTNSATVESPPGLVNPP-HVQEVGASDQSTCQPHTEQSRMDTIRQLPLLNALLIELSLLNNQPVASPAHIHPHLAW 352 
XP_012665365 353 RSLKHTNFATDEGPPVLVNPP-LIHDIGAVNQTTCHTQTEQNRINTIRQLPLLNALLVELSVLYDQPVASPTHIHPHLAW 431 
Q9P2G4       350 SCLKHPSSAAHEHPPMLVNPP-HIQNIGATNQTC---QTEQNRINTIRQLPLLNALLVELSLLYDQPVTSPAHIHPHLAW 425  human
XP_007651539 319 -PVKHTGSATGESPPVRLNPP-QMQGPGAVNEVACPPQTEQSTANAIRQLPLLNALLIELSLLCNQPVASPTQVHPHLAW 396 
A3KMW7       356 NPPEHTNSATGESCSVLINPA-SVQDTGASNQTTDHPPTEQNRINTIRQLPLLNALLVELSLLYNQPMANPTHIHPHLAW 434  domestic cattle
2_pfamImport  78 SPLKQVNTTTNESPSVLTDSPtHVQDIAASNQKTCHPQTEQNRINTIRQLPLLNALLVELSLLYNQPMASPADIHPHLAW 157 
XP_001378915 383 VPSDQNQTSMAQSHPDRGEFF------------------DQDKLDTIRQLPLLNALLVELSLLYNQPLATATGIHPHLAW 444  gray short-tai...
ELK05079     353 LYRTEHEKAPEPKAESTCKSESKKDSLPLGEIEK--SVSLQYKKNQVE-NLKKGKHFEKNSGAPQKRVPRGKLLYGLTNT 429 
XP_012665365 432 LYRAEDKKGSESFAKSTCGTESKENKLSVEDHEK--SVSPQHKKKQVE-NPQKGKHFEKSSGTPQKRAPRGRLLYGLTNT 508 
Q9P2G4       426 LYRTEDKKSPESSAKSTCRSEAKKDKRSVGGCEK--SVSLQYKKNQIE-NYKEDKYSEKSSGALHKRVPKGRLLYGLTNT 502  human
XP_007651539 397 LYRGEH-KGPEPSVKSTSGSESKSNKLSFPGNEKlgSGSVQSKKN------PNGKHSE-ISGSPPARVTKGKLLYGLTNT 468 
A3KMW7       435 LYRTEDKKSPESSVKSTCKSESKKDKLSVGENEK--SVSLQYKKNQTE-NLKKGKYFEKKGGAPQKRVSRGKLLYGLTNT 511  domestic cattle
2_pfamImport 158 LYRTED-KAPDSSAKFTCKSESKKEKLSVEEKGK--SVSLHYRKNQVE-NLEKGTYFEKNSAVPQKRVPKGRLLYGITNT 233 
XP_001378915 445 LYRPEDGKAPEPSKNATGKTEEVGDKFLPREKEK--DLNPQLTSNQVEhSLKKEVCFEKKHSIPKKVVQKRKLFYGLTNT 522  gray short-tai...
ELK05079     430 LKLRLKQTNPDMLVVHEKREQYRKMQAQMLA-AKFRIPSSKVKVLSFAERHRKPHQLPKDKYLESGASFAENNDSLKQIS 508 
XP_012665365 509 LRLRLKQTNPDMLVVHEKREQYRKMQAQILG-TKLRIPSSKIKILSFTEQSQKPHQLPEDKYLDSDVSFAENSDTSGQIS 587 
Q9P2G4       503 LRLRLKLTNPDMLVVHEKRELYRKRQSQMLG-TKFRIPSSKVKLLSSAEQSQKP-QLPEDKYLDSDASFTENSDTSRQIS 580  human
XP_007651539 469 LRLRLKQTNPDMLAVHEKREQYRKSKIQAVG-PKFRAPPWKGKVPSLAAQRQMPPQLPKDKFSDLNGSFAERSDTSRQIS 547 
A3KMW7       512 LKLRLKQTNPDMLVEYEKKEQYKKMQTQMLG-AKLRIPSSKVKILSFAELYQKPHELPKDKCLESDASFAENSNTSKQIS 590  domestic cattle
2_pfamImport 234 LKLRLKQTNPDMLVVHEKREQYRKMQAQMLG-AKLRIPSSKVKVLRCAEQLQKSHRLPEDQCLDSDGSFADNTDTSRQIS 312 
XP_001378915 523 LKLRLKRTNPAMLILHEKREQYRKMQTEMPEtEKLRLPSSKEK--SYTEEHGEPNTLPSNLCSTSDV-LAENIKSLKQNE 599  gray short-tai...
ELK05079     509 AVSDDLSTTKEAVLKC--TTE-KTVDYDENRTSNGSLEEILSPANSVVSEKFINTNDLEVk--aEMKVQSSFALQRVAvV 583 
XP_012665365 588 RFFDEPSTTKEIKLKC--ATDkKRNDCGKSRTSNGSLGEIVSPAHSTISEMLTHTSVLGG----EVEVQSPNVFLQDT-V 660 
Q9P2G4       581 GVFDEPSTSKETKLKY--ATEkKTVDCSKNRINNVSLEEVVSPANSIIPERLTPTNILGGn--vEMKIQSPCVFQQDAvV 656  human
XP_007651539 548 ACLDESSTTKEMKWSH--AVKkETVEHSENRTSNTWLEAGGCPEDSVIPER-SQSNFLGEt--sKVKVQSPELSQQDPtV 622 
A3KMW7       591 VVVDDPSTTTETKLNC--ATE-KTVDCDENRSNNGFLGEILSPANSVVSERFICTNTLEGkvfgRKSIQSPGVFQQVAvV 667  domestic cattle
2_pfamImport 313 RVFDDPSRTKEAKLKS--VTEkKTVDYSENRTNSGSLEEI-SAVKSIMSEKFTQTNILEGk--vEMKVQSPCVCQQGAiI 387 
XP_001378915 600 VESEGQSFTKETDVSEtgTEKeINIEVKINKEPAIEKDNVISP---ILTKKVTPTSV-SElfekEVKVCHLDIGSEHSrK 675  gray short-tai...
ELK05079     584 DRVVVD--KAMDDSHIKTADNDILTADagENK-LSEKSCSESISELKYSDDFTSPCYSEDFCTTEDTGRILQARDRSPGA 660 
XP_012665365 661 DRVLVD--EEIDKGPGKTTDNDILTAN--ENK-ASGNSCYENISELKYSDDFTSSCCSEDFCTTEDTNKSLQAHDSSPGA 735 
Q9P2G4       657 DRI-VD--KEIDIRQVKTTDNDILMADisDKR-TGKNSCYENISELKYSDDLSSPCYSEDFCTSEDTSRSFKAHDSSSRT 732  human
XP_007651539 623 DNI-VD--EGKDGREIKVT--DVVIADtsENRpPSRNSSCASISELQ--DEFVSPCYSEDFCMTENNSRSLLAPNSSSGA 695 
A3KMW7       668 DRTVVD--KEIDDKQVKITGDDILTVDinEKN-PSTSSCSESISELKYSDDFTSPCSSED------TSRILRACDSSPGT 738  domestic cattle
2_pfamImport 388 DRIVVD--KERTNKQVKTTDNDVLIANisENK-LSKNSCSESISELKYSDDFASPCYSEDFCTTEDTSRSLQARDDSP-- 462 
XP_001378915 676 DNI-VDysNGASDRQVETVGSDFHSLDsdDNK-SSKNSYSESVLEVKYSEDFTSPCYSEDFSSVDDTIGSSRIHDSMPEL 753  gray short-tai...
ELK05079     661 E-NSKHSQY---PRKSSETRSAMRKNSSEKSSVLSPPYSAGSPVHSCKRSHLPKTRDESLEEAPTISTSDL-SSRWTDEK 735 
XP_012665365 736 E-NPKPSQY---TSTAGETRLFIRKNSSEKSFILSPPFSAGSPVHSYRKSRISKTQDKSLEEASCISTSDLsSSQWTEEK 811 
Q9P2G4       733 E-NPKHSQY---TSKSSDTGVSKKKNSSDRSSILSPPFSAGSPVHSYRKFHISKTQDKSLEEASSISASDLsSTHWTEQK 808  human
XP_007651539 696 E-NVQHGSQ---TSKSSEARLSTRKSSSGVSPVPSPPFSAGSPVCSHRRSHVLKTSHRILEDTSSSSTSDF-SSQWTNEK 770 
A3KMW7       739 E-NPKNSQH---TSTSSETRLSIRKNSSAKSSILSPPFSAGSPVLSHKRFPVSKTQDKSLEEA---SSSDFsSSQWTEEK 811  domestic cattle
2_pfamImport 463 E-NPKR-QY---TSKSSEARLSLRKNSSEKSSILSPPFSAGSPVHSYKRCHISKTRHKSFEEASSISTSDLsSSHWTEEK 537 
XP_001378915 754 EaNNLSYSYldtDGKSSESRTSRKSHKSEINSILTPPFSAGLPVHSYKKSHLSKSQGKSLVDASNISSSDI-SSHWSERK 832  gray short-tai...
ELK05079     736 ENQIDQNSMHGSKVRTRGQDVSI--KTRTGFKSLERSQSPQTSQMSSYLPSNLSELERNVLENSTPDYFGEdsDEVGSLN 813 
XP_012665365 812 ENQIDKNGMHTSKVIKSGQDIAIklKTRTGCKSLEKSQSLQTSQVSSYLPSNLSELELNVLDNSTSDHFED--DDFGSLS 889 
Q9P2G4       809 ENQIDQNSMHNSEITKRAQDISV--KTRSSWKSLEKSQSPQTSQVSSYLPSNVSEL--NVLDSSTSDHFEEgnDDVGSLN 884  human
XP_007651539 771 ENQADPLSKGSSKVMRTGRDSSTklKVGASRKSSEKSQSPRTSQVSSYEPSNLSELELKGLDNSASADFQEedDDLGSLN 850 
A3KMW7       812 ENQRDQNSMHNSKVIKQDHDISAkpKTRTGCKSSEKSQSPRTSQVSSYLPSNLSELELNVLDCSTLDHFEEdcDDLGSLN 891  domestic cattle
2_pfamImport 538 EKQIDQNSMHSSKVIKKGQDISV--KTKTDCKALEKNQSPRTSQVSSYLPSNLSGLELNALDSSTSDQFEEdsDEVGSLN 615 
XP_001378915 833 KKQNDQNSIHNSEMSSQG--IVDksNPRTGQKSLEKSQSLRTSQVSSYLPSNVSELELSALDSFTSDQFEEn-DELGSLN 909  gray short-tai...
ELK05079     814 ISKQCKDICELVINKLPGYT 833 
XP_012665365 890 ISKQCKDICELVINKLPGYT 909 
Q9P2G4       885 ISKQCKDICELVINKLPGYT 904  human
XP_007651539 851 ISKQCRDICELVINKLPGYT 870 
A3KMW7       892 ISKQCKDICELVINKLPGYT 911  domestic cattle
2_pfamImport 616 ISKQCKDICELVINKLPGYT 635 
XP_001378915 910 ICNQYKDICELVINKLPGYT 929  gray short-tailed opossum
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