8E0P


Conserved Protein Domain Family
APCDDC

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pfam14921: APCDDC (This model is not part of the current CDD release)
Adenomatosis polyposis coli down-regulated 1
The domain is duplicated in most members of this family. APCDD is directly regulated by the beta-catenin/Tcf complex, and its elevated expression promotes proliferation of colonic epithelial cells in vitro and in vivo. APCDD1 has an N-terminal signal-peptide and a C-terminal transmembrane region. The domain is rich in cysteines, there being up to 12 such residues, a structural motif important for interaction between Wnt ligands and their receptors. APCDD1 is expressed in a broad repertoire of cell types, indicating that it may regulate a diverse range of biological processes controlled by Wnt signalling.
Statistics
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PSSM-Id: 521537
Aligned: 17 rows
Threshold Bit Score: 299.24
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8E0P_A       378 QCHHMLKHLHNGARIT-VQMPP-TIEGHWVSTGCEVRSGPEFMTRSYRFY--NNNTFKAYQFYYGSNRCTNPTYTLIIRG 453 synthetic const...
XP_002431282   4 EVSAM-------DSATtIDQVP-QIEGHWTSQECEIRPGPEFLLRNYIFW--KNNTFRLLQHYYEDESCMIPLYTVIAKG 73 
EFX89649       1 ECSSAFKRVQNGERSAhASYPP-DIKGLWVSQECETRPGPEFVLRQYHFE--RDGSFKLLQHFYGDEWCTTPVYTLTAKG 77 
XP_011150899  37 QCEVTFNEIEKEDRATiVNDSSsRLHATWLSQECEVRAGPEYIIRKYTFF--ENGTFLLLRYHYDDMSCSMPTHTVSIRG 114
EGI62201      36 QCETAIKEIRREDRATiADDSPsRLYSTWLSQE----AGPEYIIRKYTFF--KNGTFLLLRYHYAEESCSIATHTVTIRG 109
XP_011269009  37 QCEEAIKEIEKENHATiVDDSPsRLQYTWLSQQCETRAGPQYILRKYTFF--KNNTFLLLRYHYADESCSIATHTVIIRG 114
3_pfamImport   1 QCLSQLRHLQDGARIT-ALIPP-RLEGNWVSTRCEVRPGPEFLTRFYTFY--PSRLFKALQFYYEDAGCRTPAYSLVIRG 76 
XP_001341412  52 QCQAQLRHLQNEGRIT-ATIPP-KLEGHWVSSRCEVRPGPEFLTRSYTLYqsPTRLFRALQHYYSDSECQVPTYSLVIRG 129
XP_005460883  58 EPHCQYHNIQDRVRIT-ADIPP-QLDGTWVSIRCEVRPGPEFLTRSYTFH--PNRHFQALQHYYTDSSCEDPSYSLLVRG 133
XP_003425324  40 QCDFAVREIMNEDRATvVDESPsRLHAVWISQECEIRAGPEFVIRKYIFF--ENGTFQLMRHYYAEESCSIATHSVTARG 117
8E0P_A       454 KIRLRQASWIIRGGTEADYQLHGVQVICHTEAVAEQLSRLVNRTCp--GFL--APGGPWVQDVAYDLWQ----------E 519 synthetic const...
XP_002431282  74 VLTPKESSWVIPSGIDYDYSLTKVTVIPHTTQASEKLSIEKKHKCshsGIKksYLNTPWKPHLEYTLYNkh-------eE 146
EFX89649      78 QLQMREPSWVVPGAAESEYTLHRVHLVAYSEDVVDEVMQRVNRSCp--GYIn-RPWRVRKDDTSLALDE----------- 143
XP_011150899 115 SIKLLGPSSVVSGATETKFYINAVHIIPLNRQVAHKFEQKMNTTC---GPQ--PRWRPYVSRLIYEQLRqhsatqpwhsP 189
EGI62201     110 SIKLLGSSAVVSGATETKFHVDTINI------VAHKFGHRLNLTC---GPQ--PKWRPYVSEVIYEQPRqrsaasswqgP 178
XP_011269009 115 SIKLLKPSSVVSGATETRFHVDAVNILPLTPEITQKFGQKLNLTC---GPQ--PKWRLYTSALIYEQPRqhsvrslwqsP 189
3_pfamImport  77 RLRLRQASWITRGATEAEHHLLKVGIVLHSARARRQLAGRLGSSCp--GMLppAGGRPWAPGRVLELRS----------A 144
XP_001341412 130 KLRLRQASWITRGATEAEHHLHKVGMVIHSQKAIHHLATRLPSSCl--GL---KAEGHLVLHRFYELFN----------A 194
XP_005460883 134 KIRLRQASWITHGATEAEHHLSKVAIVVHSLAAKQRLASRLPSTCv--GL---SLGR-VVPGKLYELYN----------T 197
XP_003425324 118 QIKILGSSLAAPGASEARYQLDTVHVSPLNRQVAHKLSHRVNVSC---GPQ--PRWRPYMAQLIYERAPergpltwhaaP 192
8E0P_A       520 ESN-------------------------HECTKAVNFAMHELQLIRVEKQYPHhsl-------dhLVEE-LFLGDIHTDA 566 synthetic const...
XP_002431282 147 ESKsshhhhhhhkkksvrfkrkkghksfSSCLSAMGFHFNELMLIRSQWASVEgn---------kRNRE-LLLGDIHSRK 216
EFX89649     144 ----------------------------IDCLAAFHAVYHELQLIRTKKNFHLhpav-----hvqPMQTlLFLGNIHSQL 190
XP_011150899 190 VYNslqtysl------------skkrlgMDCLDTFKIGFGELKLLRVQKRLFLsktfgg-lsyhgRRLE-LLLASPAPNV 255
EGI62201     179 IYNslqihss------------akkklgMNCLEPFGIEFAELKLLRVQKKsfgssss-ndryhklPQFQ-LFLASPTPNI 244
XP_011269009 190 KYNslqat---------------nkqlgINCLEPFRIEFTELKLLRVHNKVLLghdtfngtqsydPNFE-LLLANSASNA 253
3_pfamImport 145 RAG-------------------------RDCLEALGFSMLELGLLRVETRHHAhg---------rLVQE-LFLGDIHTEW 189
XP_001341412 195 KAE-------------------------KDCLGALGFSMMELELLRVETHHHPhg---------rPAQE-LFLGDVHTEW 239
XP_005460883 198 RAG-------------------------RGCLEALGFSMMEMGLVRVETQYHShg---------gKVQE-LFLGDIHTDW 242
XP_003425324 193 RFNslhgnsghhqhqqpqqrrslevsrsVDCLSPLGIDFDELKLLRVQSRPTGfrsaaf-ggsekPRVE-LFLGELPPDQ 270
8E0P_A       567 TQRVFYRPSSYQPPLQNAKNH-NHACIACRIIFRSDEHHPPILP 609 synthetic construct
XP_002431282 217 QQD--YKPTAFQVPLLDLENA-N-DCVNCQIIAEGTERTPPMLP 256
EFX89649     191 EQRASYRPTSYQPALVRHDHQeSNDCHVCRLVAKSTDKSPPHLH 234
XP_011150899 256 SSRRTYKATSLQPTLLVHTNT-TGDCPICGSISRATELSPPLLH 298
EGI62201     245 HSRWNYKPTSLQSTAMIRADT-TSGCPICSSVSRSTEFSPPLLH 287
XP_011269009 254 HSRRNYKPTSLQSTALYRQDS-TTNCPICSSVFHSTESSPPLLH 296
3_pfamImport 190 AQRTHHRPTGYQQPLQNAMHH-VHPCPVCGAVYRSSEHRPPVLP 232
XP_001341412 240 NERVHYRPSGYQEPLQNAMHH-IHPCPVCGLVYRASEQHPPILP 282
XP_005460883 243 TQRTQYKPTGYQQPLQNAMHH-IHPCPVCALVYRSSDQRPPVLP 285
XP_003425324 271 ASKRSHRPTSLQPTALLRTDT-IHNCPICGAISRGTENSPPLLH 313
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