Conserved Protein Domain Family
MTBP_C
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pfam14920: MTBP_C (This model is not part of the current CDD release)
MDM2-binding
MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14919.
Links
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Statistics
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PSSM-Id: 521536
Aligned: 19 rows
Threshold Bit Score: 255.028
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EHB18268     629 PELSPRKLQALPFEKALVCHYHGIEYCLDDRKALERDGGFSELQSRLIRYETQTTCTRDSFLGPAVLSPIP-------SP 701 
Q0P4G8       604 PKLTPKKLKGLPFEKAAECHYHGLEYCLDNRKALDRDVAFSELQSRLIRYETQTTCTRECCPVPFALSPLP-------SP 676  tropical clawe...
XP_008115121 657 PELSPRTLRSLPFEKAADCRYHGLEYCLDNRRALERDVGFAELQTRLIRYETQTTCTKECCPVPCILSPLP-------SP 729 
6_pfamImport   1 CDLTPRKVQHLPFNKAANSHYHGIEFCLDDRNSLDRDKAFGKLQSRLIRYETHTTCSKEPCPVPFALSPAP-------SP 73  
XP_003200205 602 PDLTPRKVTKLPFLKAARSNYHGIEFCLDERKALERDRGFVRLQSRLIRYETQSTCCKEPCPVPFALSPAP-------SP 674 
XP_004077798 607 PDLSPGRVSQMPFSKASGSHYHGLEFCLDNQRSLDRDQVFARLQSRLIRYETQTTCSKEPCALPFALSPAP-------SP 679 
XP_011603789 602 PDLSPGRVSLMPFTKASALHYHGLEFCLDEKRSLVQDQAFVKLQSRLIRYETQTTCSKEPSALPFALSPAP-------SP 674 
4_pfamImport   1 PDLSPGRVSLMPFSKASASHFHGLEFCLDNQRCMDRDQAFVKLQSRLIRYETQTTCSKEPCALPFALSRAP-------SP 73  
XP_005450582 595 QDLSPRRISKLPFSKASASHYHGIEFCLDNQRSLDRDQAFVRLQSRLIRYETQTTCSKEPCALPFALSPAP-------SP 667 
XP_040551879 526 PELTPRKLRGLPFEKAAGCYYHGIEYCLDNRKALERDLGYAELQARLIRYETQTTCTKECCPLPVVLSPLPavlsplpSP 605  chicken

EHB18268     702 AVPvlvpAEPGSGSDGKPLQSELgpgpgpgpgpGPEASRLTRRSGELS---CPRPPK-RAVKSDSLDSLLSQPTGTSRQH 777 
Q0P4G8       677 AVL----SEPGSVPDGESIQTEL----------RGEPLLLKRRSRDLD---GLYASK-RLAKSGSSDSLVSLASEGSGHQ 738  tropical clawe...
XP_008115121 730 AVL----SEPGSIPDGESLQREP----------QTEASRLKRRSKDLD---GLYPNK-RLVKSESTDSLMSQASISSRSC 791 
6_pfamImport  74 AVL----SEPGSVPEGEAFQ-------------LEQKGELSRRKRDII-----FNSK-MLPKSESSNSLLSHPGGSSGHR 130 
XP_003200205 675 AVL----SEPGSVPDGEAL--------------HSEPSRLKRRSRETD----LQPHK-RFCKSESSESV-----GSAGAH 726 
XP_004077798 680 ALI----SEPGSVPDGETLL-------------NSDVSRLKCRSWEAElagGPTRRKlRLVKSGSSDSFCSPSSNSSGVH 742 
XP_011603789 675 AVM----SEPGSVPDGETLE-------------NADVARLKRRSWDMDi-lSGCPQK-RLVKSESSDSLCSQSSGSSGTH 735 
4_pfamImport  74 AVM----SEPGSVPDGETLE-------------NADVARLKRRSWDMEm-vSGYPRK-RLVKSESSDSLCSQSSSSSETQ 134 
XP_005450582 668 AVM----SEPGSVPDGETLL-------------NNDVARLKRRSWEADi-vGGYPHK-RLAKSESSDSLCSQSSSSSGTH 728 
XP_040551879 606 AVL----SEPGSVPDGESLQSEF----------RTEVLRLKRRSKDLD---CFCPRK-RLMKSESTDSLLSQASGGNGSH 667  chicken

EHB18268     778 HAVTSRKP----QPEQPSAMAHPSLSNPGSeapkAM---------------KKAGSGQNSMHESKPSGQTKESRSQKHTR 838 
Q0P4G8       739 PPTRATRL----RPERAASSTSAVQPPSAR----VQ---------------MAPSVPAQSKQSTHPDLEQKESRSQKHNR 795  tropical clawe...
XP_008115121 792 PSRVVTKQ----CLETSVSLPSLAAKQPHHq--aIP---------------KSRAASQRCGTEPGISRPTKESRSQKHTR 850 
6_pfamImport 131 AAARSLRD----QPQRSVSTASAPLKRSPSt--------------------gRECQSQGKTQGQATAQPTKESRSQKHVR 186 
XP_003200205 727 PAVEALRQ----QSARSGST--------------LA---------------RRSASVTDPSPSQKPNQTHTESRSQKHNR 773 
XP_004077798 743 STVKTLQQ----QPSRSQSTSSSVCTPAGTrhtaVSvsa----------pdGLKVQQQRTSQRNFEDKRAKESRSQKHNR 808 
XP_011603789 736 PAVRSLRR----QPGRSKSSTSSSFSSTGLss-sSStrqtasggatlpssgKHKPQQQTTLNGEAEEKTAKESRSQKHNR 810 
4_pfamImport 135 PAISNPSDpsppPPLLPTFCSGATALPSGEck----------------------pQPEKTVHGQTEEKTAKESRSQKHNR 192 
XP_005450582 729 PAIRSLRR----QPSRSQSTSSVNSSSSSAtr-pTSglatl------acvdRPKCQQQKTHQGHSEDKPAKESRSQKHNR 797 
XP_040551879 668 NAVVVTRK----RSERSVSLTSMVLKQSGQph-kAAt--------------RSGSASCVSATESETSKPVKESRSQKHTR 728  chicken

EHB18268     839 ILKE--------------VVAESLRKHCITEAHECFPACSQRLFEISKCYLKDLKTSRGLFEEMKKTANNNVTQVI 900 
Q0P4G8       796 MLKE--------------VVSKTLQKYGIGVEHPCYAACNQRLFDISKFFLKDLKTSRGLLDEMKKAASNNAKQVI 857  tropical clawed frog
XP_008115121 851 MLKE--------------VVAKTLGNHGITEDHKCFETCSHRLFEISKFYLKDLKTSRGLFDEMKKAANSNVKQVI 912 
6_pfamImport 187 MLKE--------------VVAKTLSHHGIREDHESFEACSQRLFEISKFYLKDLKTSRGLHEEMKKAANNNAKQVI 248 
XP_003200205 774 MLKE--------------VVAKTLNKHGIGSEHKCFEACSKRLFDISKFYLKDLKTSRGLHEEMKKAACNNVKQVI 835 
XP_004077798 809 MLEE--------------VVGKTLKHHGISVEHKCYEACSKRLFDISKFYLKDLKTSRGLYDEMKKAASSNVKQVI 870 
XP_011603789 811 MLLE--------------VVAKTLKHHGIGVEHECFEACSKRLFDISKFYLKDLKTSRGLHEEMKKAAGSNVKQVI 872 
4_pfamImport 193 FNKKrkshsrvmrhpqqrQIAHIL--HTITE----IVGCSTMLFQ--KYFLMDLKTSRGLNEEMKKAASCNVKQVI 260 
XP_005450582 798 MLQE--------------VVAKTLKHHGITAEHDCFEACSKRLFDISKFYLKDLKTSRGLHDEMRKAASSNVKQVI 859 
XP_040551879 729 MLKE--------------VVAKTLQKHGIAEDHKCFASCSQRLFEISKFYLKDLKTSRGLLDEMKKTASNNAKQVI 790  chicken
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