Conserved Protein Domain Family
MTBP_mid

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pfam14919: MTBP_mid (This model is not part of the current CDD release)
MDM2-binding
MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14920.
Statistics
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PSSM-Id: 521535
Aligned: 17 rows
Threshold Bit Score: 526.513
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005450582 263 EVFHYYAPVLDLVQLVNLSDLPSFLMSSVQFELCL--SGKSVKAKLLLNQLRSLCGKVGALFSLSCVITPIAQPAASQLS 340 
6_pfamImport   1 EVYHYYRPVLDLVQLVALPDLPTFFFAKCILLFNMfkRPKGDKSKLLLNQLGSLRVKVGALFALSCTVSNIVIPPSNQLS 80  
Q0P4G8       267 EVFHYYGTSLEYVQMVALSEIPSYFVSDSVFELSItrNALQGKSKLMLDQLCSLTDKVGAIFMLSCNVCSLPNPPALQRS 346  tropical clawe...
XP_007488317 295 EVFHYYGPVLEFIQMVSLSDLPSYYMSDIEFELGLtrNNTKENSKLLLEQISSLCGKVGALFVLPCSISNILIPPPSQLS 374 
XP_012039606 319 KVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELGLtrNSTKQSSRLLVEQISSLCGEAGALFVLPCTTGRIPAPPPSQLS 398 
XP_012999619 294 KVFHYYGPALQFVQMLDLAALPSCYLSDVEFELALq-DSGRQNSAVLLEQISSLCGKVGALFALPCTVSSVFLPPPSQLS 372 
EHB18268     287 KVFHYYGPALQFVQMIKLSDLPSCYVSDLEFELGLteNSSRQSSMLLLEQISSLCGKVGALFALPCTVSNIFIPPPTQLS 366 
EDM16245     287 KVFHYYGSALEFVQMIKLSDLPSCYVSDIEFELEVtgHCTRQNSMLLLEQISSLCGKVGALFLLPCTISNVLLPPPNQLA 366 
3_pfamImport   1 EVFHYYGPALEFLQMVVLSDLPSIFISDLEFELNLsrKNTKETSTLLLNQISFLSGKVGALFTLPCNVSSVVIPSPAQLS 80  
XP_007488318 295 EVFHYYGPVLEFIQMVSLSDLPSYYMSDIEFELGLtrNNTKENSKLLLEQISSLCGKVGALFVLPCSISNILIPPPSQLS 374  gray short-tai...
XP_005450582 341 SQRWRESLSRRPKSL-PVPDVEVKGESAAYFLLVQGsdnAEREACRVRMLHSDSQINGAAAMATVS---ALLREKPLSSS 416 
6_pfamImport  81 TQKWKEYMAKKPKSL-FACDPEVKGENGLYLLLVQG---TDTGDCKARLIHSASQINGAAGQATSLh--ALCSTHSEGPF 154 
Q0P4G8       347 SKKWREYMSRKPKDI-KVPGVELKGEYCSYYFLIQG---KGSGFCKATLLHSASQISGAASLVLLH---QRLNNYQPGNM 419  tropical clawe...
XP_007488317 375 TRKWKEYMAKKPKTI-TVPDVEVKGECSSYYLLLQG---NNNGRCKVTLIYSANQINGSAALSLIHg--NMKAKPEGT-- 446 
XP_012039606 399 SRRWKEYMARKPRTV-SVPDVEVKGESSSYYLLLRG---NGNGKCKATLIHSANQINGLFALSLIHg--KLKAATEETRL 472 
XP_012999619 373 SRKWRESVARKPGTLgAVPAVDVKGERASYHLLVRG---RARGQCRATLLHSAGQINGAAALSALRgarTMPAGAADIGL 449 
EHB18268     367 SRKWKEYIAKKPKTI-SAPDVDVKGERASFYLLLCG---RVRRMCRATLLHSASQINGAFALSAILg--KMKTVTADAKL 440 
EDM16245     367 SRKWKEYIAKKPKTI-SVPDVDVKGEFSGYHLLLQG---SGRRKCRATLLHSASQINGSVALTLIHg--KMKARTEAAQP 440 
3_pfamImport  81 TKKWKEYMAKKPKVI-SVPEIELKGESCRYYFLLQG---NGSGGCKATLIHSAGQINGMATLAAVNg--KLKTKAEEAES 154 
XP_007488318 375 TRKWKEYMAKKPKTI-TVPDVEVKGECSSYYLLLQG---NNNGRCKVTLIYSANQINGSAALSLIHg--NMKAKPEG--- 445  gray short-tai...
XP_005450582 417 GAAAGNVLhSLPCLQGDYLLRRERRVSQVQKLALQEYLKKK----GAASIPVNDLKVILNLARENYLKKADSTLPTAA-- 490 
6_pfamImport 155 GTDVSTWLgSMPCLHGDQLMQRERGLTNVQTLALKEWLRRReenkKPASVPVNDLKALLTLAREQYLKMHDARIPRTSfk 234 
Q0P4G8       420 AEGTSEILdSVPHFRGEQIAVRERILARAQALAVNEYLKRHealpHPSVSHVNNLRTLLAVTRERVIGDCESRLDGVSyk 499  tropical clawe...
XP_007488317 447 GYPID-FIcSLPCFSGEQVVQREKQLAKVQDLALKEYLRRKesieQPVTVSVDELNTLLSLTRERFIEFFDASIPKTAlh 525 
XP_012039606 473 SSPLD--LsSLPRFSKEQLIQRERQLASAQASALKECLQRRklaqQREVISVDELKSLLTCTRERFLGHFDALIPKTSli 550 
XP_012999619 450 RCPVD--LtAIPRLSGEQVVQREARLAAAQALVLRGCLERRklakEPAAFSADEFRSLLRLTRERFLRHLDALTPKMVlk 527 
EHB18268     441 SGPFD--LlALPNFSGEQVVQREEHLATAQASVLKECLERRklakEPVAFSADELKSLLRLTRERFLHHFDVLTPKTVlr 518 
EDM16245     441 SFPFD--FsSLPRFSEEQVLQREKQLASVQVLALKECLKRRkaanQPEAVSTDELKSLLALTRERFLDRFDVLTPKAVlt 518 
3_pfamImport 155 GFCISDFIkSLPCYCGEEIVQREAKLSHLQMFALKEYLKRKeltkQPVVISTNEFKSLLKLTRECFLDLCSTSLPKPVlq 234 
XP_007488318 446 SYPID-FIcSLPCFSGEQVVQREKQLAKVQDLALKEYLRRKesieQPVTVSVDELNTLLSLTRERFIEFFDASIPKTAlh 524  gray short-tai...
XP_005450582 491 ---ACLTDNQASKSSGFQII------SQLPSDWPERSVLHNVENLQKRRQKRRFGLLgPGSSDSLLGPKDGQRGSSTLLD 561 
6_pfamImport 235 rleKCSENWKVYGSDARNM---------TRLEWPERRVLQNFENQEKIRQKSRTAVLlSGSSDSLLGPKDSQRCPSAMLD 305 
Q0P4G8       500 nlqNITVSTPTVSESEAMIS--------NPADWPERNVLQNLENFEKVKQRLRASIL-SSSAEQLLGRKDGLKEGMTLLD 570  tropical clawe...
XP_007488317 526 karNKIKTSEILREst--------flESNHLEWPERHVLQNLETFEKAKQKFRTPML-SRSSEQLLGHKDGHRESVTLLD 596 
XP_012039606 551 -ktD--ETSSMLHDSSSLELtssrlvETNPLEWPERHVLQNLETCEKAKQKMRTGSL-PRSSEQLLGHKEGPRDSVTLLD 626 
XP_012999619 528 -qgHKITTSAMLNGAAQVEPdssnpvETSSLEWPEKHVLQNLETVEKASQKIRAHSL-PRSSEQLLGHKEGPRDSVPLLD 605 
EHB18268     519 -qiDKIKTSAVLNAASRVEPdssnlmETSSLGWPEKHVLQNLETFEKARQKMRAASL-PRSSEQLLGPKEGPRDS-GLLD 595 
EDM16245     519 -qtDTMKAAGMVNDASRVESyssssmETNPLEWPERHVLQNLETSEKAKQKMRTGSL-PHSAEQLLGHKEGPRDSITLLD 596 
3_pfamImport 235 kvcSKTRSCTVTCEPDLIEP--------NPLEWPERHVLQNLENFEKNKQKMRVPLF-AHSPEQLLGHKDSQRESLTLLD 305 
XP_007488318 525 karNKIKTSEILRESTFLES--------NHLEWPERHVLQNLETFEKAKQKFRTPML-SRSSEQLLGHKDGHRESVTLLD 595  gray short-tai...
XP_005450582 562 AKELLKHFTSDGLPAGELQPLAINRGNNAF 591 
6_pfamImport 306 AKELLKHFTPEGLPTGELQPLQIQRGENAF 335 
Q0P4G8       571 AKELLKYFTPQGIAVGELQPLQVQRGDNAF 600  tropical clawed frog
XP_007488317 597 AKELLKYFTADGLPVGDLQPLHIQKSENTF 626 
XP_012039606 627 AKELLKFFTSDGLPIGDLQPLQIQKGEKTF 656 
XP_012999619 606 AKELLKHFTSDGLPVGDLQPLPVQKGGKTF 635 
EHB18268     596 AKELLKYFTSDGLPLGDLQPLPVQKRDKTF 625 
EDM16245     597 AKELLKYFTSEGLPVGDLQPLQIQRGEKPF 626 
3_pfamImport 306 AKELLKYFTPEGLPVGDLQPLQVPKRENAF 335 
XP_007488318 596 AKELLKYFTADGLPVGDLQPLHIQKSENTF 625  gray short-tailed opossum
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