Conserved Protein Domain Family
MTBP_N

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pfam14918: MTBP_N 
MDM2-binding
MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920.
Statistics
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PSSM-Id: 494670
Aligned: 9 rows
Threshold Bit Score: 289.368
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007488317   1 MDRYLLLLTW-----GErrsetadrepgnrpaasSSASDGPEISpgl----taANVYHCVKRSISASMNAeDSTF----P 67  
XP_005450582   1 MDRYVLVISFcrtddES-----------------PDGFKCLEPL---------KQIYGRLVDISTQESEK-VSVF----P 49  
XP_003200205   1 MDRYVLAVIInleakKD------------------SSFNGVDET---------KKVFDNLKKISGSNLTR-IPPF----P 48  
EDO45970       1 MDNYCIIIIDeesfnGE-----------------FARISDLEETv--------ERLFEGLLQHDEVFKQSyCPKLrdsdP 55  
Q0P4G8         1 MERFVLCIHWerr-----------------------aeSGAEQHrvpqglayaQDIYTQLKEYST----KyTSTF----P 49   tropical clawe...
XP_008115121  50 MDRYLLLLSWagrrgl------------------egnqgGREGAsgl----taENIYNLLERNCTPSVNAkLEDF----P 103 
XP_001098134   1 MDRYLLLVIWg---eGKfpsaasr---eaehgpeVSSGEGAEKQpdf----taANVYHLLKRSISASINPeDSTF----P 66  
EDM16245       1 MDRYLLLVSW-----REgkfrsvag-gemepgteASSLESTEKQphl----taTNIYHLLKRSINDSIHPdDSTF----P 66  
1_pfamImport   1 MDRYVLVVSFnkqedED-----------------INCFTGLTAA---------NKVYESLKEISINSSKRkVSPF----P 50  
XP_007488317  68 ACSVVGVPGPKKWFFAVQAICGFYQFCSSD--WEEIhfDTQKEESEDSLETDIEECLNAVRCLEEEDSNSrESLSLTDLF 145 
XP_005450582  50 ACSLSGSPSARRWYFAVQACHGGAQFCTSK--WEEL--SLHRCDSEEEKPTALEACLGSLKNQEAPDQKA-DELTLTELM 124 
XP_003200205  49 ACSSSGSPASQRWYFAIQASYGVTQWCSSE--WDEV--CSQRSDSEESEASALENCISALQEQEEQSSLT-ENPSHAELF 123 
EDO45970      56 VASLLCRSTQTYLSIIVAKKLQSFQESSSDclWNPLsaPSLFHKIKES----LKPCTNT---HSSGDGDAdDNDNVED-- 126 
Q0P4G8        50 ACSLTGNPGTRKWFFALQSLYGSFQFCSSD--WDDLcpAVTTEDNEEPVQTALDECLEALQFPDGEDDNSrDSISQTNLF 127  tropical clawe...
XP_008115121 104 ACSLVGIPGVKEWYFAIQSICGFSQFCSSD--WENI--DFEADQDKSSIQRNIEECLGDAQCMQEEDSNSrESLSFTDLY 179 
XP_001098134  67 ACSVGGIPGSKKWFFAVQAIYGFYQFCSSD--WQEIhfDTEKDKIEDVLQTNIEECLSAVECFEEEDSNSrESLSLADLY 144 
EDM16245      67 ACSVGGTPHSRKWFFAAQAICGFYQFCSSD--WQEIhfDAEKDKIEDVLQANVEECQSAVECFEEDDSNSrESLSLADLY 144 
1_pfamImport  51 PCTLTGIPAPQRCFFAIQSSSGSSQFCSSE--WESVgtTSVKNDSEESATSVIEAYQCTLQRLEEADENRcSKPNEIALQ 128 
XP_007488317 146 EEAAENLHQLSDKLPAPGRAMIDIILQPFEKDSSKLKDCLPAIGALKHLKE---WHSAKITIAANNCKGsCQKIATY--- 219 
XP_005450582 125 EEAAEGLHVLSDKLPPPGKALLDVLVLGSAEQSPPVKDLLPLLGAVKHMSS---WHAAKISVITQHTPG-WQKMASS--- 197 
XP_003200205 124 EEAAEGLHQLADKLPPPGKSLLDVIVLCVDEEVG-LKDMLPVIGSLKHMRA---WHSAQMIMVTEHSAG-WQKAAMY--- 195 
EDO45970     127 NKIATRLHQLADSLIGKDVSQLNVYWICAEPDTDLSRDNLLLFGALKRLQI---WNGAHLTLITSH-----QDDSGYgel 198 
Q0P4G8       128 EEAAELLHQLSDKLPAPGRALVDVLLF--TPEAPKLKDCLSAIGAIKHLKE---WHSAKITIVSKDCKG-WQKIAKF--- 198  tropical clawe...
XP_008115121 180 EESAESIHLLADKLPAPGKAMVDVIWQTSEIEVPSLKDCLPVIGALKHLRE---WHAAKITIVTNENQSsWQKVADY--- 253 
XP_001098134 145 EEAAENLHQLSDKLPAPGRAMVDIILLPSDKDPPKLKDCLPTVGALKHLRE---WYSAKITIAGNHCEInCQKIAEY--- 218 
EDM16245     145 EESAENLHQLSDKLPAPGRAMIDVILLPSDKDPPKLKECLPIVGALKHLKE---WHSAKVIVAGSHCETnCQKIAEY--- 218 
1_pfamImport 129 NAIALSFVVLSMGLTVRSYTVVSSF----SAEQSLLLQCAGVYDKTYHEERcipWITKSVLIICDCSQ--WQKTATY--- 199 
XP_007488317 220 --------LSADIVALDDIKNVID--SRELWRGKIQIWERKFGSEVKFPEFSLRGISPKIHN 271 
XP_005450582 198 --------ISAALVKLADLDSCID--SKEMWRGSLLIREKKCVSELRFDGFSLHQISESGLL 249 
XP_003200205 196 --------LDARLCSPSVIDSCVD--GTEIWRGGLNIREKKFVSELKFEGFCLRAQRRNHWT 247 
EDO45970     199 itdswlqpLSPTVITTSHISVYVQrpSDVIWQGAIKYNSQKLKSLVSLPDFVLIQQYKEKDG 260 
Q0P4G8       199 --------LSANVVESACPKELID--SHELWRGNIEISERKFTSEVEFPEFCLRSVSDDKFP 250  tropical clawed frog
XP_008115121 254 --------LSADIVAPENLQSSID--PRELWRGKIQIWERKFASEITFPDFCIKSIESKKPL 305 
XP_001098134 219 --------LSANVVSLEDLRNVID--SKELWRGKIQIWERKFGFEISFPEFCLKGVTPENFS 270 
EDM16245     219 --------LSATVVPLEEFGNAID--SRELWRGEIQMRERKFGFEVNFPEFCLKGVTPTNVS 270 
1_pfamImport 200 --------LSAHILDPQNLGSCID--VEEIWRGNILIREKKFASEVRFGGFCLKNVPCDTWS 251 
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