Conserved Protein Domain Family
DPCD
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pfam14913: DPCD (This model is not part of the current CDD release)
DPCD protein family
This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD). This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants.
Links
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Statistics
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PSSM-Id: 521532
Aligned: 26 rows
Threshold Bit Score: 251.405
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001956075   6 WLNYLQSAEKNSMISGRLRKVLYKFPDGQQMAEEYNMDTGIIQRRAWRKCKQLMGEPEWEIELGEEPRQLNwsgnkqtgp 85 
Q0IEH0         6 WLTKIRGADKSSAIQGTVRKVHYSFPDGTEMAEEYSTETGCVLRRAWKLRSDLLRKDDWEIELGEPIPK----------- 74  yellow fever mo...
EEZ97894       3 WLSQLKSAKKSCMVQNNLKKVHYDFGNGKEMVEEYNMDTNVVTRRAWKVKGEMGGEGEWDIELGDPEVNPT--------- 73 
XP_002431095   6 WLTAISNSEKTCIIQD----VHFKFSDGQEMVEEYNLETNVVVRRAWKVTKKFGSQPKWEVEIGDPEPCFQ--------- 72 
XP_011254805   6 WLKIIQNAKITVLIEDGKRKVHFLFENGKEMVEEYNMDTNVVVRRLWKKKNNFGTDIGWIVEIGEPEPK-E--------- 75 
XP_001014069   1 --metQKPTVTCLIIGGKRCLQYTFPDKTEMVEEYDMKSHELLMRKIKKASNF-KEAKWEYEIGEAPLNPN--------- 68 
XP_002672300  22 epsttkyPYTTSVVADGRRKFHTTYENGVEMVEEFDLQTNQLLLRKRRTVSILGEGT-WTIEIGGEVKSFN--------- 91 
XP_002503253   1 --mfrkgGKSTSMNHGGRRRVVTEFDDGGEMIEEYDLKTDELLLRKRRGRTVLGKDEEWEYLTGEAPRTFS--------- 69 
XP_003061271   1 --mfrkgGESTSVNQGGRRKVHTTYPDGAEMIEEFDLKTDELLVRRRRGRTTLGKDTPWEYLVGEAPRTFA--------- 69 
Q384D8         1 -msvtlsEPKSSVIVNGRRRITSKFVDGGEMIEEYDVITDDLLLRKYRSRTTLGGFSAWEVEVGNEASTRN--------- 70  Trypanosoma brucei

XP_001956075  86 ggdAdSlagSEFTVRESNTAPLLTK-RVTKKNIEWRIRNMPYALEVYNVTASPEQR----AIIVRTTNKKYYKVIPVPDL 160
Q0IEH0        75 ---AlKndhDGFALQEAATEPFLSK-RVTRNCIEWRIRNLPYPLSTYTITCEGDAR----TITVRTSNKKYFKKIAVPEF 146 yellow fever mo...
EEZ97894      74 ---Ke----QNLIIRENSGQPVVSR-RNTRINLEWRIRNLPYPIETYSVTVDNEKN----CLVVKTTNKKYYKILRVPEL 141
XP_002431095  73 ---EdM---ENSGIKESSTAPTTTA-RITKNCLEWRIRNLPYPIDNYTVLASQDDN----CIIVKTKNKKFFKKIRVPDL 141
XP_011254805  76 ---NnI---EKDGIQESSNTPFVTQ-RITKTCLEWRIRNLPYPSNVYSVTAEEDN-----TITVRTSNKKYFKKLKVLDL 143
XP_001014069  69 ---Q-----QEQLLKATSANPIFLR-KDTDRDFQFRIRNLPYPEEVYQIEVDEEKQ----QLVVRTTNKKYFKRIDVPDL 135
XP_002672300  92 ---P-----IHDLIAPSTVNPIFMR-KDTSTLFQWRVRNCFYEPNVYKVNIDHEKQ----EIVISTTNKKYYKRFSIPDM 158
XP_002503253  70 ---P-----DVGILAESSVNPTWQRsQDTPQSFVWRVRNLPYPIETYQVTCDHGDQ----KIVIRTTNKKFYKRFDVPEL 137
XP_003061271  70 ---P-----DTGTLIESGANPSFTRsQDAPGSFVWRVRNLPYPKETYDVRCDHEAQ----QVVIRTSNKKYFKRFEVPEL 137
Q384D8        71 ---L-----DKELVVETSGSPEVVK-QDALEFYVFRIRNLPYAKEVFSVAVEHSKPtdmgEIVVRTSNKKYFKRLSIPDM 141 Trypanosoma brucei

XP_001956075 161 DRC-GVAPAQDNISVHHQFNTLIITYKKPDILCEMEAQVLLLLKNVETETD 210
Q0IEH0       147 QRC-GFAPKVEDLMVKHQYNTLIIAYKKPAILVEMEKAVLAELQNVETVEY 196 yellow fever mosquito
EEZ97894     142 DRL-RIAPQHEAIQIAHKYNTLIITFKKPKELLEFEKKVLEEVSKIQPKNF 191
XP_002431095 142 ERI-GVKLEQDKIDYSHKFNTLIISYKKPPQLILSEKLILEEVNKLKSVKE 191
XP_011254805 144 ERI-GLKPEQERISFKHQYNTLIITYKKPLELLNVEKKILSRILQFKPIES 193
XP_001014069 136 ARY-NLKLEKGKATFSYKNSTLLISYPKPDPILLRESERRKQFEKLNAKKp 185
XP_002672300 159 KESpKTKLNDESLSFKLENNTLIISYVKPDLILKKERAKEMELASMKSErp 209
XP_002503253 138 KVL-KLSLQDDALSYDWKNNTLIVQYKKPREVIKAELEEKVETQQLRLKra 187
XP_003061271 138 KLL-DKKLEDAALSWDYRNFTLIVQYKKPREAVVAEIEEKKDRMQLaakkt 187
Q384D8       142 NRR-NLKLDPAQLSFDVQHNTLIIRYKKPLVVLAAESAAKKERASLPAKri 191 Trypanosoma brucei
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