Conserved Protein Domain Family
MMS22L_C

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pfam14911: MMS22L_C (This model is not part of the current CDD release)
S-phase genomic integrity recombination mediator, C-terminal
MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more C-terminal region of the proteins.
Statistics
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PSSM-Id: 521530
Aligned: 22 rows
Threshold Bit Score: 348.115
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEC05240      197 DQMTRLSGMVLELKELNQLlLGTLTRP---DGGESHdvfVTRLFTSVAEASDILSDVGdteGTTRLQQTLALYLQDFVVT 273 
XP_023037105  754 EVVVALTQHISQLEEFRQLqLEPASLQ----ASREP---LCSFFRALGQRVQHQEESEglhMRMQYSHKLHAYVYHFEQW 826 
NP_001284794  728 ESVLALMPHVTQLEEFRLLaIDPTSLE----GGREP---LCAFFGALGRRAQQEEAAAh--VRMQLSHKLHAYVNHFELW 798 
XP_002011235  744 EAVLALNPFVIQLEEVCALgLDADSLA-----DREP---LCAFFGALGRRAQQQEALAh--VRMQLSHKLHAYVAHFDQW 813 
XP_001992262  753 ESVLALTPHVAQLAEFRALgLDASSLE-----GREP---LCAFFGALGRRAQQQDAVAh--VRMQLSHKLHGYVAHFEQW 822 
XP_049539279  715 E-LRDLTRIVYRLNEFRVL-CDIPEYDl-lETDAVP---MHLFLRYIGKRFRETHDGN---EQLQLKMRLHHLFQHFDRW 785 
XP_001843854  718 EQLVELSRVVCGLGVFQEI-CSIAEVDl-cEGKDDL---MGLFFKALGDKYNEKDSRG----QLEMSSKVNALFHQFDAW 788 
EFN83552      701 EELKILQHYITGLDEIKEIfISDNDLQefrNNSNEP---ILTFIISFMKKQNLLKSEQ---EKIQHTGKCKAYFKNLEKW 774 
XP_016852698  855 DQLVELTRLILKLPEVEAV-FSKAHVNv-pVCRQDPkeaVIQFVKAFGKNYSSLQTLA---EKSTTVTKALEYIGDVLKH 929 
E1C2Z0        850 EQLTEMTRLIFKLKEVESI-LSKARVEe-pVLKQDPknaLVQFIKAVGRTYSGLQTLP---EKSAMVLKALEYLGDVLKY 924  chicken
EEC05240      274 VAGVLKSSSAtSAALQNVYAICGQLFKHCSTLLyTKGLSGCLLPQLLDCLVVPSVVHAKKP-LSQAHLMALKHQLPQFLD 352 
XP_023037105  827 LPPD--RLR--SELGSRFFSFLAIVIYNCPTLSyVRSKPSCFFHLAMVRFLLTTQLQAGTP-PEPRLPQIVHKIFPVLLQ 901 
NP_001284794  799 LPPD--RSRS--ELGSRFYSFLAIVIYNCSTLAyVRSKPSCFFHLAMVRFLLTTQLQAGVP-PEGRLPQVVHKIFPVLLQ 873 
XP_002011235  814 LAPQSRQERP--ELGARFYNFLAIVIYNCPTLCyVRSKPSCFFHLAMVRFLLTTQLQAGVA-PEGRLPQLLHKIFPVLLQ 890 
XP_001992262  823 LPPALTEQRP--EIGARFYNFLAIVIYNCATLTyVRSKPSCFFHLAMVRFLLTTQLQAGIQ-PEGRLPQLVHKIFPVLLQ 899 
XP_049539279  786 IP------EPtGIVRQRILSVLVLALKECDQAFyIRSNPSCLYHLAFQQYFLPVSVLTDRQ-LAADYVEDMARVWHRVMD 858 
XP_001843854  789 FP------SPtTSLLIRIMSMLVVAIKECGQVIyKRGNSACLLHLAFSRFFLPSSVLTNRN-VPNDLVLAMGKVWHRIMD 861 
EFN83552      775 VLLPITEETKdSEVAFWIYRCLGTLILCISPTLyTKNQPNDMLRTLVNKVIL-----VPENsTQPYIKQLGKKIFSMVIL 849 
XP_016852698  930 VKPYLMKKGP-AEGFHLSYRIIGCLVKSWAPIL-ATTKAQPLLFRIIDCLLLPHAVFQQDKgLPAAMLSAIRENLPLFVQ 1007
E1C2Z0        925 VKPYLKAKGP-PEGLQLAYWIIGCLVKFWAPIL-ATSKAQQLLFRIIDCLLLPHSVLQQDKeLPGALLSAIQESLHLYLQ 1002 chicken
EEC05240      353 GL---LSFRIRLDPYLLRRVKDIITHYLSLFSLTQSAIYNTGPHPLLVVLdtgAGSRAsqk-reLYVSLLLDCICDNFIP 428 
XP_023037105  902 GI---GRLSYTSDTYLGKTLEQLIHHWTPHF--SFTTNVKLVARPYSILLqadNDGEL--------AQYVLNQLTSQFLA 968 
NP_001284794  874 GI---GRLPYRTDAYVAKTLEQLVQHWTPHF--SFSSNAKLVARPYATLLqadVDGEL--------AQFVLQLLVTQFLV 940 
XP_002011235  891 GI---GRLPYRTDAYLSRTLEQLVLHWTPHF--GFSSNVKLVARPYATLLqadSDGEL--------AHYVLQHLANQFLA 957 
XP_001992262  900 GI---GRLPYRTDAYLGRTLEQLILHWTPLF--GFTSNVKLVARPFATLLqadADGEL--------AQFVLQNLASQFLG 966 
XP_049539279  859 VL---SRMAYQSDSVIGDRVINMLTKWLPQFAKLPSKAPREMVRPLMLFFcgsGSNEA-------LVSYAMPRVASTFVE 928 
XP_001843854  862 VL---GQMSYLEDPVIGDYAAKMMPKWAPQFLKFKTN--ADAVKPFLVFFt--SRNEA-------FVKFALNKYLAYYVE 927 
EFN83552      850 GL---EKLNIKGDILLQAMIRDIFDQYLPILITEINNGGNFRVSDMLLKCfkeAKCEF--------MRSIFETLMSNFYN 918 
XP_016852698 1008 GLsfiCCQSQTQGAYLNQLLGNVIQQYLGRFFPSSSSASRTGQHPILLAM---CSSPTnmlgalHLYKITMQVISENYLQ 1084
E1C2Z0       1003 GLsfiCCQSQARGAYLNQLLGSIVQQYFGRFLPPSPTALGAGQHPMLTAL---CSSITvpq-alRLRKTTLHVINEHYMQ 1078 chicken
EEC05240      429 KKGVA--HAHFGQGIRFIQEVVKRVRPTqneySSIIKAL----------LPALFENLLNSSTD---AKLCRELVTQILRD 493 
XP_023037105  969 VQRRKa-GTHAGLIITLLQQLMEGLNVEqe-rELLTLLRa--------iHSPLLEHIMFVDELehsRGQVLAIYRILVSL 1038
NP_001284794  941 VQRRRa-GQHAGLVITIMQQLIESTGK-----EQEEQLLtvl----rgvHIPLLEHVMFVDEVdlsRNQVFGLYKVLISH 1010
XP_002011235  958 VQRSQa-GTHVGLILTVLQQLFVGLDDLelgpEAEAQLLtll----ravHVPLLEHVMFVGELepsRVQVLSLYAVLVNL 1032
XP_001992262  967 VQRNQv-GANVGLILMVIQQLFVGLGETkdapSAEPQLLtll----kavNIPLLEHIMFVGELepsRIQVLNLYRQMVHL 1041
XP_049539279  929 LQRCLp-KPNALPVMRMLQWLLQELIASadyaKVALFVRl--------fGLPIVMHAVMCSASqptRGIATTLVYDMV-A 998 
XP_001843854  928 LNGATp-KLQAEIGLKLLTFLLEALNNAqdngKIAMFIGi--------vAPATLEHALLVHDQslsKPVANELTSLML-T 997 
EFN83552      919 ISSDNvmHKHSNLITWLIKTLLK---------EGKKYPKytvehivqicSPHIFGCYVKVHDHhphKLHTIDFISDVVKS 989 
XP_016852698 1085 FKGHAp-PSNLAPTLAFILEALRKTKTTem-yEVDVF------------LPPVLKCLLLVNEPl-vKKLSTEILQCVVEG 1149
E1C2Z0       1079 FKGSAp-PPRLASVLAFILEVLQRTQASel-cDVELV------------LPAVLKCMVLVNELq-vKKISTVIVQYMVQG 1143 chicken
EEC05240      494 SKDKLGAGEHESLEEALSSFVGRNLAWSTSGVFRLLHDVATLHPRLVADAMSKITVAAQDVERKRGGGSDAAIRKNLSDL 573 
XP_023037105 1039 PVFKSSTKAKEICSSVVCSLAKKHLAHCTYFYFQMLIKLAEQAPELVRPLLPFVKQEAEMVELKRGAGEDVGIRKCLQRL 1118
NP_001284794 1011 DAYKRSQAVRDMCSNHLRSLAEKHLAHCTYFYFQMLINLAELAPDLVAPILSFIREQAEQVELKRGAGEDVGIRKCLQRL 1090
XP_002011235 1033 SQFQRSAAARDICSTDIRNLAEKHLAHCTYFYFQMLIKLAERAPQLVAPLFGFVREQAHSVELKRGAGEDVGIRKCLQRL 1112
XP_001992262 1042 GVFQRSMAAQEICSDDIRSLAEKHLAHCTYFYFQMLIKLAEPAPQLVAPLYSFVRKQAVNVELKRAAGEDVGIRKCLQRL 1121
XP_049539279  999 STSGPSNVVRDEMRTVLANFTRKYLPIAADTYFVFMCRLADRNPLFIRSLIDTVREELLQAERLRGTGTDSFLRKSLYRL 1078
XP_001843854  998 STQNGSNLIKMELKTALANFTKKHLRINTSNYFRFMYKLADQRPEFIESLISTIRLELTETERLRGNGEDMHLRRMLSQL 1077
EFN83552      990 PYYEEDRIIREKFQAAVSTMVQKYLTLNTQPTFEFIRSVLPIKKDMIISLFPQIETVVSQAEQYRRHNA-VSLRFMWNQL 1068
XP_016852698 1150 CQARSEGEFATQLTSVFRQFIQDYTTVYGNQVYSILEAVAVLDQSLVISLIPAMTEALRNSEYKQGLGRNTLQREAYKRL 1229
E1C2Z0       1144 CQARSGGEHATQLTSVFRQFIQDYTAVYDHRVFSILETVAVLDQTLVTSLIPTLTQSLKDSEYKQGLGRNAAQREAYKRL 1223 chicken
EEC05240      574 LSHI 577 
XP_023037105 1119 QQVF 1122
NP_001284794 1091 QKVL 1094
XP_002011235 1113 QQVL 1116
XP_001992262 1122 QQVL 1125
XP_049539279 1079 EGAV 1082
XP_001843854 1078 QGAV 1081
EFN83552     1069 KKHM 1072
XP_016852698 1230 LSQL 1233
E1C2Z0       1224 LTHL 1227 chicken
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