Conserved Protein Domain Family
MMS22L_N

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pfam14910: MMS22L_N (This model is not part of the current CDD release)
S-phase genomic integrity recombination mediator, N-terminal
MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more N-terminal region of the proteins.
Statistics
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PSSM-Id: 521529
Aligned: 15 rows
Threshold Bit Score: 1160.22
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
B3DIY3         29 PPCFTCAYeagrEDTGRLSSNGYISRGALKRLLLKLDPAPADFGGDTVDIFDFPWVTETALVESTKLLFGLFRQKVLKLE 108  zebrafish
B1AUR6         26 PPCFSCAFdn-rEG--KFSGESYLASGALKRLILNLDPLPTNFEEDTVELFGFQWVTETALVYSCRELFHLFRQQIFNLE 102  house mouse
XP_016852698   34 LFNFSCASdl-tNGGKSFSPDSYLASGSFKRILLGLDPFPTDYEEDTVELFGFQWVTETALVESCTLLFGLFRQQIQKLE 112 
E1C2Z0         26 PPCFSCIFdn-qNGGRSFSGESYLASGSLKRVLLRLDPSPNDYEEDAIEMFGFQWVTETALVESCGLLFGLLRQQIYKLE 104  chicken
XP_012818992   28 APRFSCAPtscsGNGNTFSSSSYLSSGSLKRLLLRLDPSPTDYESDTVEIFDFPWVAETALVESTDLLFGLFRQKLDILE 107 
XP_015210961   29 PPCFCCVS----EPSRAFSSEGYITSGALKRILLRLDPSPAAYETDTVEIFGFLWVTETALVESAKLLFSLLKQKVHRLE 104 
XP_003965949   29 PLCFSCSEtk-dDPSRGFSTEGYIARGSLKRLLLQLDPAPAECETDTIEIFGFVWVTETALVESTKLLFGLFRQKVYRLE 107 
4_pfamImport    1 PPCFSCCEak-dEQAAALCPEGYLGRGSLKRLLLRLDPAPAEFETDTVEIFGFPWVTGTALVESTKLLFGLFRQTFYKLE 79  
XP_011483162   29 PPHFCCSEvk-dEAAAALSPEGYAARGSLKRMLLRLDPAPAECEADTVEIFGFVWVTETALVEKTKLLFGLFRQNVYKLE 107 
5_pfamImport    1 PPCFTCVYeagrEDTHALSSDGYVSRGVLKRLLLKLDPFPACFETDTVDIFGFSWVTETALVESTKLLFGLFRQKVFRLE 80  
B3DIY3        109 TLVQSsS-HDFGQASSLHYEAEELRQQCVLFLSYIKVFIYRFLEPSQSLDEG-PVHPFKDAEAQLPSVLVEELFSITLLI 186  zebrafish
B1AUR6        103 SLVQV-S-CDFGKIATLHAKADSIRQQCVVFLHYIKVFIFRCLKVQEAESHSrPAHPYEALEAQLPSMLVDELRGLLLYI 180  house mouse
XP_016852698  113 ILLQ--S-NDFGQAAQLHWEAHDVRQQCTEFLQYVKMFIFRYLETHVMEEDE-LLHPYEKQETQLPSLLVEELHSLTLHI 188 
E1C2Z0        105 DLIEMnS-SDFGKAANLHSEAENIRRLCINFLHYVKVFIFRYLEPPKTENDG-VLHPYEELEAQFPSLLVEELHSLTLHI 182  chicken
XP_012818992  108 NLCQPlS-LDPGQLSNIHIEAEEIRSQCVQFLHYVKVFIYRFLDPPQKMDTI-PVHPYEELEAQLPSKLIEELHGLRLYL 185 
XP_015210961  105 TLVQSnT-HDFGQSSNLHFEAEEIRQQCVSFLQYVKVFISRFMESSSVLNDG-PSHPYEEQEAQLPSGLLEELHSVVLYI 182 
XP_003965949  108 TLVQSsStRDFGQVGNLHYEAEDLRQQCVSFLQYVKVFLYRFLPPCSCLDTD-AVHPFHKLEAQLPSALLEELFGITLLI 186 
4_pfamImport   80 TLVQSsS-HDFGQAGNLHYESEELRQQCVSFLQYVKVFLHRYFEP--CLDAA-HSHPYEQLEQQFPSALLEELFAVTLLT 155 
XP_011483162  108 TLVKSsS-HDFGLAGNLHYEADDLRQQCVLFLQYVKVFLHRYVEPSSSMDAG-PSQPHEELELQFPSALLEELFGLTLLT 185 
5_pfamImport   81 TLVQSsS-HDFGQASGLHYEAEELRQQCVLFLSYIKVFIHRFLDVSQPMDEG-FVHPYSELEAKFPSSLVEELFGITLLI 158 
B3DIY3        187 GRIGNLPANVQSAFTIQHQGKLFPPSWQLLHLHLDIHWSVLEILHLLEQRMMGQVVYAHQFVNLTGETLTNISLFEDQVN 266  zebrafish
B1AUR6        181 GHLAALPSVTVGAFVNQNQMKLFPPSWHLLHLYLDTHWLVLEILHILGEKL-KQVVYGRQFIGQAGDNLTNVSLFEEHCE 259  house mouse
XP_016852698  189 GHLHELPSCVLGGFTILPQAKLFPPSWHLLHLHLDIHWSVLEILHILGEKMPRQTVYAHRFINLTGENLTNVSLFEEHCG 268 
E1C2Z0        183 GHLCELPSNVLAAFTIQHQAKIFPPSWHLLHLHLDIHWLVLEILHVLSEKMMRQVVYANHFINLTGENLTNISLFETHCE 262  chicken
XP_012818992  186 GHLCELPNNIQAALQLQHHGKVLPASWHLLHLHFDVHWSILEILQILGDKMQGQIVYAHEYINLIGENLTNVSLIEELCE 265 
XP_015210961  183 GHLRDLPSNIQGAFTIHHQGKLFPPSWHLLHLHLDIHWSVLEILHLLGEKMIGQVVYAHQLINLTGENLTNDSLFDEHCT 262 
XP_003965949  187 GRLKDLPASLQSAFTMSNQGKIFPPSWHLLHLHLDIHWSVLEILHLLGNKLQGQVVYAHQFVNLTGEYLTDTSLFEEHLC 266 
4_pfamImport  156 GRLKDLPAGVQAAFSMQNHGKIFPPSWHLLHLHLDIHWSVLEILHVLAHKMQGQVVYAHRFVNLTGENLTDTSLFEEQLA 235 
XP_011483162  186 GRLKDLPANVQSALVIQNPGKIFPPSWHLLHLHLDIHWSVLEILHILGHKMQGQVVYAHQFVNLTGENLTDTSLFEDHLC 265 
5_pfamImport  159 GRLKDLPSNVQSALTIHHQGKLFPPSWHLLHLHLDVHWAVLEILHLLGQKTMGQVVYAHQFVDLTGETLTNISLFEDHLK 238 
B3DIY3        267 NLFCDLIGLAMNKYNKVRPTETLNTHHYHCLCTKELWILLIHLLEHRSKSIHTQSFWSYINALLQTVLKGTTSGDRDPgF 346  zebrafish
B1AUR6        260 HLFCDLICLSLNRFDKVMPSEALLISHCPCSCVKELWVLLIHLLDHRRKWSVADSFWNWLNKLLRTLFEKSSDQRRSS-V 338  house mouse
XP_016852698  269 NLLHDMISFSANRYTKIRPPEALNSPHYPCICVKELWVLLIQLLDHRNKGSHTESFWSWLNKILKSVFEKNNGTEETPsF 348 
E1C2Z0        263 NLISDLISLSIQKYTKVRPSEALTSHHYPCNCIKELWILLIQLLGFRNKGSQTECFWSLVNKKLKSIFERPTSSESVSvF 342  chicken
XP_012818992  266 DLLCDLIYYAANRYAQVRPSEALNDQIYHCICVKEMWILLLQLLDHRSKGSSSESFWIRVNKLLKSLNQGSNSMESHRiS 345 
XP_015210961  263 NLLCDLIGLALNKYIKVRPTDALTSCHYYCSCTKELWVMIIHLLHHRSKVFHMESFWAYINKLLRILLKGASPDTLKEyF 342 
XP_003965949  267 NLLCDLTGLAMGKYSKVRPTEALSIHHYLCPCTKEFWVLLMHLLEHRHKAMRRQSFWSYMNSLLRPLVSGKPAPEQFRgL 346 
4_pfamImport  236 SLLCDLTALASGKYSKVRPTETLNSSPFLCLCTKELWVLLMYLLQYRNKTLRTQSFWSYMNPLLKPVVDGQPAPEHLGgP 315 
XP_011483162  266 SLLCDLTGLAMGKYSKVRPTEVLSSNHYLCTCTKEIWILIMHLLEYRNKTLHTQSFWSYMNSLLKPLALGQPGADGFSgL 345 
5_pfamImport  239 NLLCDLIGLAMNKYNKVRPTEALTSHHFYCICTKELWILLIHLLEHRSKTLHSQSFWGYLNALLQAVLKGAPSGD--TgL 316 
B3DIY3        347 PV-HCKDPEGFTWWLLTHLAQIGMHNRNGTAQQEKQLEDNWSFVIGLLKSICDPKKAAQEEQIRVVVHCCLSLSLMWGPN 425  zebrafish
B1AUR6        339 SLtQAKDPLGFSWWISVHVASLYQIDRHGVSDKMKQMESNWSFIEELLKRSVTVQDSILEEQLRMHLHCCLTLCDFWEPN 418  house mouse
XP_016852698  349 GSiPCNDPLSFSWWIITHLAPLYHIDRNGHVDKEKPIESNWPYVEGLLKRSINSQMGILEEQLRMHLQCCLTLSYIWDVN 428 
E1C2Z0        343 GTtQCKDPLSFSLWIVTHLASLYQFDRNGNLEEKKQKESNWKFVEELLKNSIGAQTGVLEEHLRMHLQCCLTLCRFWDWN 422  chicken
XP_012818992  346 KTvQCKDPLGLSWWLIAHLSPLYTFDRNGNREEAVQISSNWKFIEDLLKKSSDAQNGVREDELRMHLQCCLSLCDIWESN 425 
XP_015210961  343 PS-HCKDPLGFSWWLVTHLAELSQYSQNGAIERKQKLEDNWSFVEELLKCSCDTQVNILEEQLRMYVHCCLRLCQLWDSN 421 
XP_003965949  347 PT-HCNDLLGFTWWLVTHVSMLSQYNRNGTPQTEKNVGDNWNFVEELLKLTCNPKQGLPEEHIRMHVHCCLSLSLLWEPS 425 
4_pfamImport  316 LT-HCKDPLGFTWWLLTHLAMLGQYSRNGTMQNEKCLEDNWTFVEGLLKKTCDPKGGLAEEQIRMHVHCCLSLCLLWEPS 394 
XP_011483162  346 PS-HCKDPLGFTWWLVTHLTMLGQYSRNGTIQSEKHLDDNWTFVEDLLKLTCNPKRALAEEQVRMHVHCCLTLCLLWGSS 424 
5_pfamImport  317 PA-HCKDPLGFTWWFLTHIAQLGMHSRNGSLQSEKQMEDNWSFVLELLKSSCDLKAALQEEQVRMHVHCCLSLSLLWGTN 395 
B3DIY3        426 VSAVTTFWEYYSKNLNSSFTVPWLGVSGLGSICRTPLCLLQQAKSCCSpapvgSSSHTQLYRTANSFHIFLRILALHLSQ 505  zebrafish
B1AUR6        419 ISVVTILWEYYSKNLNSSFSISWLPLKGLTNIIKSPLSMLTLVRNCCS-----DKQDPDLYKSSSSYIIFLCILAKVVKK 493  house mouse
XP_016852698  429 LSAVTILWEYYSKNLNSSFTIPWIGLKGLANITKTPLSMHKVVKNCCG-----DIHTPDLYTSSNSYQIFLCILAQIMKK 503 
E1C2Z0        423 LSVITILWDYYSKNLNSCFTVPWLGLKGLASISKTSLSMLELVKSCCC-----EQQIPTLYKSSNSYLIFLSILARMMKE 497  chicken
XP_012818992  426 LTAGTILWEYFSKNLNSSFTIRWLGLQTLACVSKSPCSMLEVVRSCCT-----DKPSLDLYKSDNSYLIFLRILARLMKK 500 
XP_015210961  422 VTTITILWEYYSKSLNNVFTIPWLGLKGLASVSKTPFSMLELVKSCCR-----EEQSPELYRTSTSFHIFLCILALQMRK 496 
XP_003965949  426 TSAVSTLWEYYSRNLNASCSVKWLGVSDLGTLYKTPLALLAQARSCCSpsplhSLGHTQLYRSASSFHIFLRVLALCLAQ 505 
4_pfamImport  395 TAAVSTLWETYSRNLNSSFTVPWLGVSGLGAVCKTPLALLEQARSCCCpsaprSPGHAQLYRSANSFHIFLRVLALCLGQ 474 
XP_011483162  425 TTAVSILWDYYSKNLNASFTVPWLGVSALRTQFKTPLAVLEEARRLGCpspvrSPGHTQLYRSASSFHIFLRVLALCLGQ 504 
5_pfamImport  396 TSAVNTLWEYYSKNLNGSFSVPWLGVSGLGSISPTPLTLLEQAKNCCSpdpvtSASHLQLYRSANSFLIFLRMLALHLNQ 475 
B3DIY3        506 --EHAGGAPWRQIKGRLYSKFHQRRMMELSDMGLLHFLLLFLVLAQCAELEDVASRACDLLAMLPTNSTPLALRALQWRG 583  zebrafish
B1AUR6        494 amRTSGPHPWKQVKGRIYSKFHQKRMEELTEVGLQNFFSLFLLLAAVAEIEDVASHVLDLLRFLRPASMS-SHGALVWKG 572  house mouse
XP_016852698  504 avRTSGVHPWKQIKGRIYSKFHQKRMRELTEVGLQNYFYLFLLLAAIAETEDVSSRMTELLRCFSPTSTSIPLRALIWRG 583 
E1C2Z0        498 eaESSGVHPWKQIKGRIYSKFHRKRMQELTEVGLQNFFNLFLLLAIVAETEDIVSRVLDLLDFLTPSLVSPSQRALIWRG 577  chicken
XP_012818992  501 dkESRGAHPWKQIKGRIYSKFHQKKMQELTEVGLQHFFILFLLLAIVADTEDVASRVIDLLQFLVPGHLSTSQRALLWRG 580 
XP_015210961  497 --GTTGTHPWKQIKGRIYSKFHQRKMQELSEAGLMNFLSLFLVLAATAEMEDVVSRVSDLLALLSPASISVAQRALIWRG 574 
XP_003965949  506 --DGVAGFPQRQIKGRVYSKFSQKKMQELSETGLMNFLLLFLVVARQVELEDVASRACELLGFL-PSNCPTGHRTLIWRG 582 
4_pfamImport  475 --DRAGGAPQRQIKGRIYSKFSKKKMQELSEGGLMNFLLLFLVVARQAELEDVASRACELLGFL-PSNCPPAHRTLAWRG 551 
XP_011483162  505 --DGVGGVPQRQIKGRIYSKFSSKKMLELSEAGLMNFLLLFLVVARQVELEDVASRFCELLGFL-PSNRPPAHRSLVWRG 581 
5_pfamImport  476 --DSAPGAPWRQIKGRIYSKFHARRMAELSDSGLHHFLLLFLVLARCGDLEDAAGRASDLLTLLVPGSVSPTLCALQWRG 553 
B3DIY3        584 QLALVLLYLEKGLDVGALAEQLAVYFSQAAREFYLKTTE-PSRKLALWAPLSSYLEGVSEVFETSPNLTLSEERLLNEGF 662  zebrafish
B1AUR6        573 QMAFLLMYAQKNLDIGVWAEKLSCEFQEKAKEFLVSKNDeMVQRHALWTLLCIYIDGVQEVFETSSCLYPSHEHLLNDGF 652  house mouse
XP_016852698  584 YFAFMLTYVEKNMDISVLAEEISNAFHEKAKEFLVGRND-LMQKQNLWMLLSTYLDGVQDVFEISRCLNLSEEKLLSEGF 662 
E1C2Z0        578 HFAFLLIYVEKNMDISVLAEKLSNAFRVKAKEFLVTKND-YTQKQNLWTLISTYIDGVQEVFETSCYLSLSEEKLLNDGF 656  chicken
XP_012818992  581 NFAFLLIYVEKNMDISALAEKLSHSFRETAKEFLVTKGD-FGQKHTLWTLLSTYVDGVQEVFETSHNLQLSEEKLLNDGF 659 
XP_015210961  575 QFAFILLYEEKGLDVGVLAEQLSLAFKQVAKEFYLKTTD-HTRKLSLWTLLSTYIEGVQEVFETSSYLHLSEEKLLNEGF 653 
XP_003965949  583 QLSLLLLFQERGLDVGAQASALASSFNQTAKEFYSKTTE-VSRKLALWGPLSSYMEGVVEVFETSTNLSLSQEKLLNEGF 661 
4_pfamImport  552 QLSLLLLFQERGLDVGAQAGCLASSFNETAKEFYSKTTE-VSRRLALWGPLGSYLEGVAEVFETSSGLGLSEEKLLGEGF 630 
XP_011483162  582 QLALLLLFQERGLDVGVQASWLAASFNETAKEFYNKTTE-ASRRQALWGPLGSYLDGVAEVFEMSSSLSLSEEKLLSEGF 660 
5_pfamImport  554 QLALLLLFGGHGLDLAPLASKLSSSFTNAAREFYLKTTE-PARRAALWQPLSAYLEGAAELWQTSTTLCQSEEALLGEGF 632 
B3DIY3        663 GLLLPACRQSELSSALGFLQTVLAQLRRVHQRCGQ--PSHSVDSPSWAPl-pSVAKERHQ-AVAAALWSHFFPFLCSMRL 738  zebrafish
B1AUR6        653 SMLLPACRESELRTVLNFLQAVLARIRSVHQQLCQelQRENVDLTVQSS---LSAKERPLaAVAGALWRHFFSFLKSQRM 729  house mouse
XP_016852698  663 SMLLPGCRGAELSTVLNLLQDVLFRLRAVHKQLSQglPLGNMVPNAQAA---SVAKEHHL-AVAKALWRNFFPFLKSQRT 738 
E1C2Z0        657 TMLLPACRGAELSMVLNFLQVVIARLRSVHKRVSQglQPGNADSNAQLP---LVAKEHHL-AVASALWRNFFPYLKSQRM 732  chicken
XP_012818992  660 SMMLPACRESELCSVLNFLQTAVARLRNIHSRSIQgpGNNSSHAQTL-----LVVKEHHL-AVANGLWRNFFPFLKNLRL 733 
XP_015210961  654 GMLLPACRESELQTTLCFLQTILAQLRSVYKRSAQslQQSHTAAVQNAPt-pFVAKERHL-AIASALWGNFFHFLKSLRL 731 
XP_003965949  662 DWLLPACRVSELNSALSFLQVVLAQLRRVHQHSVQsaPN--SSLAPSSV---SAVKERHL-AVAAALWAHFYPFLRSLRL 735 
4_pfamImport  631 DWLLPACRQSELNSVLSFLQIVLAQLRRVHQRSVQsaPI-----PAWAPapaSVIRERHL-AVASALWLHFFPFLRSLRL 704 
XP_011483162  661 DWLLPACRQSELNSALSFLQVVLAQLRRVHQLTVQsaAT-----PAWAPplnSVVKERHL-AVAAALWTHFFPFLRSLRL 734 
5_pfamImport  633 GLLLPACRTSELNTALSFLLTALTQLRSVQQRFKQlgPS---DCPSWAPp-pSVVKERHL-AVAVALWTHFFPFLRSLRL 707 
B3DIY3        739 S 739  zebrafish
B1AUR6        730 T 730  house mouse
XP_016852698  739 M 739 
E1C2Z0        733 S 733  chicken
XP_012818992  734 S 734 
XP_015210961  732 S 732 
XP_003965949  736 S 736 
4_pfamImport  705 S 705 
XP_011483162  735 S 735 
5_pfamImport  708 S 708 
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