8G2Z


Conserved Protein Domain Family
HU-CCDC81_euk_1
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pfam14908: HU-CCDC81_euk_1 (This model is not part of the current CDD release)
CCDC81 eukaryotic HU domain 1
This is the first of two HU domains found in the CCDC81-like proteins. CCDC81 has been experimentally linked to the centrosome; eukaryotic CCDC81 HU domains are predicted to function in protein-protein interactions in centrosome organization and potentially contribute to cargo-binding in conjunction with Dynein-VII. A striking lineage-specific expansion of the domain is observed in birds, where the HU domains could function in recognition of non-self molecules.
Links
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Statistics
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PSSM-Id: 521527
Aligned: 31 rows
Threshold Bit Score: 80.0186
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8G2Z_0T       18 PGKHQDSQPRTNPAYkPLEAKAQFHIIFKATGEYIREKMLDGKGVNMRDFGAFTFEifsdtvkp---------------- 81  Tetrahymena the...
CEM00581     266 PGPHTEPQPRTSQGLvPMDTTRQLLLIWDAFCDYLIENMEKANSVHIPNFGTFMFEnivrvnrtgvlakdeftlsaiepi 345
A0CDE3        18 PGRHNHQQQRTLSIYrDLTTKDQFLLVINSLKELLQDCYSKGNSLHIHNFGTFSFEfigpt------------------- 78  Paramecium tetr...
A0DDZ3        18 PGKHQESQPRTIASYkPLEAKAQFHIVIKATAEYIKEKMLNGNGVNMKELGAFTMEvnsdyvkp---------------- 81  Paramecium tetr...
XP_004032552  20 PGKHLESQPRTNPSYkPLEPKAQFHIIFKATSEYILEKMKDGKGVNIPDFGAFTFEvfsdwikp---------------- 83 
XP_001022994  18 PGKHQDSQPRTNPAYkPLEAKAQFHIIFKATGEYIREKMLDGKGVNMRDFGAFTFEifsdtvkp---------------- 81 
Q4CQT9        42 ASIVASTQGLYYHQTrGNGGTDLLNRIWRSMGELLEEQLLLKRSCIVTDFFHASVKvqn--------------------- 100 Trypanosoma cruzi
Q383J9        23 ANIVAQMGGLYCHQSr-NAGPQLLCRIWRTLCESVEETLVRKRSCIIPDFLHASIKvqr--------------------- 80  Trypanosoma brucei
XP_004035822  18 PGKHQNQQNRTNPDLkPLNLMDQFKIIFKALKVYIYERMLEGNSLNLHNFGIFGFEicqdtsrp---------------- 81 
XP_002366855  21 PGPHQESQRRVTEDLaPVDPTRQLLLIWDAMCDFLSEQVQQGKGVTIKDFGSFIFErri--------------------- 79  Toxoplasma gond...

8G2Z_0T       82 -----aqhsnfdIAKDLDeqradrkhvhrirPCFVPDKKFRYSLARYA 124 Tetrahymena thermophila CU428
CEM00581     346 nrthkqaapdgmQYADMPtylrpd--glearACFNVDEKLKGVLHRFP 391
A0CDE3        79 -------sqaipIKQSTQlkqlpk-lyqnirPCFIVDPYLQKQLSRYS 118 Paramecium tetraurelia
A0DDZ3        82 -----lqhsgfnMTQDLGiqraerkhvhqirPCFVPDNSFKYFLARYP 124 Paramecium tetraurelia
XP_004032552  84 -----aqhsnfdITKDLDeqrtdrkhvhkirPCFIPNQKFKYALNRYP 126
XP_001022994  82 -----aqhsnfdIAKDLDeqradrkhvhrirPCFVPDKKFRYSLARYA 124
Q4CQT9       101 ----------iqYYDGKHvf---------ykLQLVLLPDFTSKFHLQN 129 Trypanosoma cruzi
Q383J9        81 ----------vsPFDGEInl---------ykPQMVLLPDFLSKFHVQN 109 Trypanosoma brucei
XP_004035822  82 ----tihsnlceIAKDFQnnisdrlhkhrmrPFFAPDKNLKNALVRYP 125
XP_002366855  80 ----------eaTPPKVPelghapgekeaviPRFVVADTLMKELTRQN 117 Toxoplasma gondii ME49
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