Conserved Protein Domain Family
DUF4495

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pfam14906: DUF4495 (This model is not part of the current CDD release)
Domain of unknown function (DUF4495)
This domain family is found in eukaryotes, and is typically between 322 and 336 amino acids in length. There are two conserved sequence motifs: QMW and DLW. Proteins in this family vary in length from 793 to 1184 amino acids.
Statistics
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PSSM-Id: 521525
Aligned: 20 rows
Threshold Bit Score: 411.289
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005457551  532 SFIESCGRAAFAMLGRLQERALEVPSSAPLKNL-----HALLATCIYVHQRLEHYSARLKds---stAAAKITLTPLPVQ 603 
Q3UPC7        515 NLVEAYSKVATAVLERLQERGKEVPSRAPLKNL-----HSILSSATYVSQRFTHYDNLMK-------ETTKKPIFLVPVQ 582  house mouse
XP_002110311  460 KFLPILTNDYGKIYTSLKVVIVDVICQKAIADMspspaYLAIATAAFIKNRLLTFDQILS--------TDTRLSFFTSYE 531 
XP_002042673   99 KFVQLVTKSADLLLEHIHRLSQESLDHADLSVL-----TATIGAASLVKNSLSVYMQAATtticppkGDEKGGALKLSFK 173 
XP_015832883  103 KFVSLINKSAEQLLEHLHVLTQEALDHADLTVL-----TGTIGASALLKNCLWFYLQSINe-----iKGSQVELLHESYK 172 
9_pfamImport    1 EFVTTVCTCCSQLMVHLHNLSQEALDHADLQVL-----TSTLGAAALVANALWIYNHHKE-------RLPPGMSFNNSLK 68  
XP_002429007  101 EFLKVIEDTAAQLLEHLHILSQEALDHADLTVL-----TGTLGASALVKNTLWCYNEHLN--------LKEGLSLHESYK 167 
XP_019696545  100 DFILLVVDTAEQLLEHLHMLIQESLDHADLTVL-----TATLGAAALVRNCLWCYNQHAKgv----iSSQSSEKINKLYK 170 
XP_007487356  516 NFVEACCKVATAVLARLEERSKEVPSKVPLQNL-----CTLLSTAIFVFQHFMHYDDLMK-------ETSKKPLFLVPVQ 583  gray short-ta...
XP_028925977  549 NFVEACCKVATAVLERLEERSKELPCRAPLQNS-----YALLSSAIYVCQRFRRYESSME--------EIKEPLFLGPVQ 615  platypus
XP_005457551  604 KYKDTVEAMREQLTSYCIQACYTCILQDAESHHWADPKPFYEGERCSFSVQMWFYFLCGLRSDLWAVLPAELARDVLGQV 683 
Q3UPC7        583 RYQEFINTVQFQVTDYCARVCAMSILQDAESHHWDDYKAFYEGERCSFAIQMWHYFSLALHHDLWTILPPKLAQEILAEM 662  house mouse
XP_002110311  532 HYADLVESLCELIVEHHNTTISTTVLQDSDSNNYSNPRTFYEGKRCSFSIQMWNYYLHSIRHDLWQYCPLKQAQRIFISV 611 
XP_002042673  174 QYSQMSEALAERLLDLHCRLLLLYIMQDADCLHWEDTQPFFESERGSYTVQMWWHYMRGTQTDLWNSVPPKMAQKIFAGM 253 
XP_015832883  173 KYQEMGEALAERLLDLHCRLLSLYILQEAESLDWENQKPFCESERGSYVIQMWWLYMQGTREDLWNTVPPKMAQRVFSGM 252 
9_pfamImport   69 EYQSMREALAERVLDLHCRLTSLYVLQDADCLDWENKHPFFESERGSFVVQMWWLYMEGTRQDLWTTLPPKTAQRVFAGM 148 
XP_002429007  168 NYKEMSEALAERLLDLHCRLLSLYVLQDADSLSWDYPHPFFEGERGSFVIQMWWLYMQGTRQDLWNTVPPKTAQRVLAGM 247 
XP_019696545  171 EFHEMAEAVAERLLDLHCRLISLYILNEADSLSWHSNKPFFERERCSYVIQMWWLYMQGTKADLWNTVSPKMAQRVFAGM 250 
XP_007487356  584 RYQELISTLQFQVTDYCVRVCATSILQDAESHHWDDYKAFYEGERCSFSIQMWHYFCCALHHDLWAVLPPKLAQEILIDV 663  gray short-ta...
XP_028925977  616 RYQEFISTLQFQVTDYCDRVCATSILQDGESHRWDDYKAFYEGERCSFSIQMWHYFCCALHHDLWTLLPPKKAQEILIEV 695  platypus
XP_005457551  684 LTDTLQLLVRRYARARASYRRHLQIRCDITAMLLYVEHLMWSLCESPETLVRYnpssvitiIAGGSDWPYQIHNLCEQLL 763 
Q3UPC7        663 LEKSLGLLASRYARAHPSPKRTAQIRLDVMAILIFTENMLWSICSSGQEILNP--------HKFNNHKIFKIHTHCNNLF 734  house mouse
XP_002110311  612 LENSLLTLSFRYGQIKPSLRRLCQFRADINAIILISLSFIWFTGQTVNSLVNPdfhalstaDFNPQSEIPKIYNYCNLLL 691 
XP_002042673  254 LNETLSVLTVRYTQIVTSVARSTLHLVDICNMLLCIAELLPHICESGEAYVGLq-------LSNQSVIIRDIHAKCKELF 326 
XP_015832883  253 LNESLTILTVRYTQSCPSEARSKLLVVDISNLLLCIAQLLPSICDKAEELIGLn-------LNNKSKILRDIHTKCQELL 325 
9_pfamImport  149 LNESLTIFTARYSQAVTSIARLPLIANDICNILRCIAHLLPALCSCAKELTGE---------KTISQVVAHIHHKCHLLL 219 
XP_002429007  248 LNETLTILASRYCQAEPSPARLSLLVTDIGNLLLCVNEILPSICSNASEFLGF----------SNSKILRDIHCKCHQLL 317 
XP_019696545  251 LNESLSIITTRFTHGRPTLARSEQFWSDAFNVLCCTGYLALAACIDSDEMIGAr-------PSNLSTAVRDMHAKCNELL 323 
XP_007487356  664 LEKSLDLLASRYSQAHPSYKRTPQIRFDVTAILICTEQMLWSVCRSVQELLNP--------RECINEKILKIHAHCNNLF 735  gray short-ta...
XP_028925977  696 LEKSLELLACRYAQANPSYERTPQIRFDVTAILICTESMLWSVCSSSRQLLNP--------NEDTDDDIIKIHTHCNNLF 767  platypus
XP_005457551  764 TVLVIVTAPLSLLHRTFMIDA-AK--ETSPDP-PTIPVIRWLNAINPdvFTEQAIR------DGLMGQASLACQLRLLTS 833 
Q3UPC7        735 TTLAILTSPLTELYKTFQHGV-DEspSNSLTP-LFNQPLHWISCMSQ--FYPSLLR------PPSVGGLTAQGQLKLLLS 804  house mouse
XP_002110311  692 MIVVAESCPIDVYPKAISRFQ-DG--SKISGS-NNICGTFWLSNYLPdmFSSIELS-------DIPPQVSLKIAIKLLRH 760 
XP_002042673  327 YCLLLRGSPLGVLSKVFRKGL-DN--MEMFSS-RHGLPSAWIIFALPryFPKEQSCqwvtefSDLSTNTAISLDLRVLLA 402 
XP_015832883  326 NCLVLRGASLDTLQKVFRKGL-ET--VDLFKS-RNTGPASWITFSLPniFKVQPKNit--rmSDLPPDAAIALELTVLLA 399 
9_pfamImport  220 TCLLFRGAPLSTLHKIFFRGL-DK--VECFKPvPQGDFSPWFAFVTDdidyg------tksvFDLTPSSAILLELNILKL 290 
XP_002429007  318 LCLSLRGCPLSILYKLFKNGF-DD--VIAFEN-RAKSIAPWLIFVSPelLQLSLGEr----lTSISDEYAIMLELKVLIA 389 
XP_019696545  324 VCLLLRGTPLKELYQVFRHGL-EN--LTILRP-RRG-PAPWLLICVPnlLGSIDNPad---iVTLSEDKAVVLELNVMRH 395 
XP_007487356  736 TTMVILTSPLTELYKTYQNDTdDLp-SDSSES-PFNQPLHWISCIEH--FSPSFLR------TPSAGEMAVQGRLKLLLS 805  gray short-ta...
XP_028925977  768 TTLVILTSPLTKLYETFQNGF-DD---HASDL-CIQEPLHWVSSIAH--FFPSLLR------TPSAGKMAVEGHLKLLLS 834  platypus
XP_005457551  834 DPGCNPKLLLQMLLYRDCHLPRILLENS 861 
Q3UPC7        805 QPCCKWNLLLDTLLHSGGLIPRILLKSS 832  house mouse
XP_002110311  761 RTGIDLKLILQILLSNKFSALKLIITET 788 
XP_002042673  403 FPEADWSYLLKILLMRDAYLTGIIMRHL 430 
XP_015832883  400 QPQPNWSLLLKVLGMKNCKLLKLILDLS 427 
9_pfamImport  291 QPNHSWCLLLKLLMMRDCWVAFRLMKYV 318 
XP_002429007  390 QPQPCYPLLLHVLTMREYKVITLLLKKI 417 
XP_019696545  396 QPQPNWPQLMKVMSMSNHVVARMLLRSL 423 
XP_007487356  806 QPCCNWNLLLETLLQDDCLILKILLRSE 833  gray short-tailed opossum
XP_028925977  835 QPCCNWNLLLETLLQRDCLLMKILLRSS 862  platypus
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