7BVH,7BVF


Conserved Protein Domain Family
Arabino_trans_C
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pfam14896: Arabino_trans_C (This model is not part of the current CDD release)
EmbC C-terminal domain
Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate.
Links
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Statistics
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PSSM-Id: 521519
Aligned: 52 rows
Threshold Bit Score: 432.382
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7BVH_A         714 VVSLTLGMINQYPAWSVGRSNLNALTGKTCGLANDVLVEQNANAGMLTPI--GEPAGQAL----Ga------vTSLGFGP 781  Mycolicibact...
WP_012832179   722 LALFAKAAAVRSDTYTTFSANMRALTGNTCGMADDVLVESDPNVGALQPIg-TTDISRAL----Ag-------DSTGFTP 789  Gordonia bro...
WP_013128696   743 GAIFAKATVSNPATYTVAKGNLDTLRGDSCGMAEKVLVETDPSDDLLQSAd-GRPAAQAL----Tg------tASHGFLP 811  Tsukamurella...
WP_013139657   695 FVDFAAAAYSRYPAYSLALGNVRAAAG-GCGLADAVLAEADPNAGFLRPAd-GMDPKSAL----Ga------vQSVGFTA 762  Segniliparus...
jgi:Tpau_1783  684 GATNAASILVQHPAYSYGKQNLESLAGNPCGMADEVLAERDANEGVLTPL---GNSPEPL----Ig------aENENFTP 750 
WP_013128695   712 GTLTATTVLTQYSSYSVGKGNLRALVGKECNMADFVLTEPDATGGLLTPL--GGDVRNGL----Ag------pGTVGVSP 779  Tsukamurella...
WP_279102062   722 IVTAAFSAINQSSSFSTPRSNLEALAGNECGMADWVWVEEDPNRDMLRPV--DRTLPNPLggptTppgsdaqpGTVGFSP 799  Gordonia bro...
WP_014358507   722 LVTAAFAGIHQSDSYSVPRSNLEALAGKQCGMADKIWVEENPSSYELSPV--DKTLTDPLagpaTqpasstepATSGFGP 799  Gordonia pol...
WP_239707514   691 MASMAIGVVRQYPTYSNGWANIRAFAG-GCGLADDVLVEPDSNAGFLTPLpgAYGPLGPL----Gg------eDPQGFSP 759  Mycolicibact...
Q9CDA9         706 IGSMVAGIVRQYPTYSNGWANIRALTG-GCGLADDVLVEPDSNAGYMTALpsNYGPLGPL----Gg------vNAIGFTA 774  Mycobacteriu...

7BVH_A         782 NGIPSDVSADpvmeqpgtdnfadsdsgvvt-gtevgteggttaaagingsrARLPYGLNPATTPVLGSWr-sGTQQPAVL 859  Mycolicibact...
WP_012832179   790 DGVAPDLLPDpeslgagtintsgnlarpfvlsggppgttggvgpvgvngsrVKLPFGLNPRTTPVLGSFg--HDNETAEL 867  Gordonia bro...
WP_013128696   812 DGLPDELKPLaissapgqinmaspitqpftstaatagtgggrgprtvngstAALPFGLDPARTPVVGSYg--QNTVPAEL 889  Tsukamurella...
WP_013139657   763 TGLPEEAAALgdgtppgiahvnhsgsepv---pvdgqeagtsagysqsthtLSLPFGL-AQDTPVLGSYg--YNTGEARL 836  Segniliparus...
jgi:Tpau_1783  751 NGLATDLNTTsrgaadllntgdadttasn----tggtgggtlstagvngstAALPFGLDPKRVPVIGSRqqgASQRTAKA 826 
WP_013128695   780 DGVPPIINATtssatddsstsldamvrl-----pqettsgrtdsagingshMKLPYGLDPARTPVLGSYs-aEQQNRAKV 853  Tsukamurella...
WP_279102062   800 NGVEDDLSSTasegslgvlagnvwaapdilnsnpggtgggvlptpgingsrAKLPFFLDPATTPVMGSYs-kTDQIPAKL 878  Gordonia bro...
WP_014358507   800 DAVPEELDTKtpagalgvlagdaaadpdvlianaggtgggeestpgvngshAALPFELDPSKTPVLGSYs-kDDQTPAHL 878  Gordonia pol...
WP_239707514   760 DGVPDRIIAEairlnnpqpgtdydw-----------nrpikldepgingstVPLPYGLDPKRVPVAGTYs-tEAQQESKL 827  Mycolicibact...
Q9CDA9         775 NGVPEHTVAEairitpnqpgtdydw-----------eaptklkapgingsvVPLPYGLNPNKVPIAGTYt-tGAQQQSRL 842  Mycobacteriu...

7BVH_A         860 RSAWYRLPD-RDQ----AGPLLVVSAAGRF----------DQGEVEVQWATDe-----QAAANEPGG-SITFGDV-GA-- 915  Mycolicibact...
WP_012832179   868 TSGWYRLP--DRN----ASPLLVITAAGPVfsvdqdgvaaPGRSLKVQFGRAg----tTPDAFEPMGpGYVPIDP-GPtk 936  Gordonia bro...
WP_013128696   890 FSDWYSLPP-RSA----DRPLVAFAASGAIasvgptgkkeYGQPVTLEWAERr-----ADGSLGAQG-VLDPIDP-GP-- 955  Tsukamurella...
WP_013139657   837 VSGWYELGP-ISK----DTPLIVMSAAGHIasayldgtgiYGQDVAFEFGAR------RDGGVAATG-SVPAIDP-GDpq 903  Segniliparus...
jgi:Tpau_1783  827 VSSWYALPAgGVD------TLLTISVAGRFd----------tGNIRLEFGT-------GSGEITPAG-AVTPIDI-GP-- 879 
WP_013128695   854 VTQWYPLPA-PSA----DRSLLTLSAAGRFt----------dDELYLEYTTAp----vTGPDLPVAG-KKGFIDI-GP-- 910  Tsukamurella...
WP_279102062   879 TSGWYALPA-GWR----DRPLLTMSVAGEy----------DNPNLMLQYTSDpigpntRDGDLTPAD-ETELIDP-GP-- 939  Gordonia bro...
WP_014358507   879 TSGWYALPT-DYR----GRPLVTFSIAGQFd---------NPQDLVLEYTTGkigpttRDADLAATG-SVNMIDP-GP-- 940  Gordonia pol...
WP_239707514   828 SSAWYELPA-RDEteraAHPLVVITAAGTItgesvangltTGQTVDLEYATRg-----PDGALVPAG-RVTPYDV-GP-- 897  Mycolicibact...
Q9CDA9         843 TSAWYQLPK-PDD----RHPLVVVTAAGKItgnsvlhghtYGQTVVLEYGDPg-----PNGGLVPAG-RLVPDDLyGE-- 909  Mycobacteriu...

7BVH_A         916 -APA-WRNLRAPLSSIPPEATQIRLVASDDDLAPQHWIALTPPRIPELRTLQEVVGsSDPVMLDWLVGLAFPCQRPFDHR 993  Mycolicibact...
WP_012832179   937 pNRP-WRNLRIPMEAVPAGATAMRIVALDNNVSPDQWLAFTPPRAPRLRTLQQVVGsDAPVLLDLSVGSQFPCQRPMTTR 1015 Gordonia bro...
WP_013128696   956 -NKP-WRNLRVPMDAIPPSANVIRIHVRDPNLGEQQWVGVTPPRAPRLRTLQDVVGtQDPVLLDLLVGQQFPCQRPMAIR 1033 Tsukamurella...
WP_013139657   904 tSYP-WRNLRLPTSAVPTGSTLVRVVVNDHDLQQDQWVAVTPPRLPHLVTLQQLIGsTDPVFLDFAVAEQFPCQRPFGAQ 982  Segniliparus...
jgi:Tpau_1783  880 -PPA-WRNLRVPAGQIPRGATAVRVRAEITAPSERTWVAYTPPRAPKLVTLQELLG-DDPALVDWGAGIGFPCQRQWREF 956 
WP_013128695   911 -KPA-WRNLRLPRTDLPDGVTAVRVVAIDDDLAIDHWLAITPPRMPALQTAQQLIGsTDPVLVDWTSGLTFTCQRPFLHR 988  Tsukamurella...
WP_279102062   940 -RPS-WRNLRYDTKDLPADTTAVRIVATDDNLSEDRFIVVTPPRVPKMRTLEDVVGrEAPVHVDWTSGLAFPCQRPFDHH 1017 Gordonia bro...
WP_014358507   941 -MPS-WRNVRVPTTDLPDNITAVRIVATDDNLASDRYIIVTPPRLPQMRTLQDVVGsTAPVHVDWTSGLVFPCQRPFTHH 1018 Gordonia pol...
WP_239707514   898 -TPS-WRNLRYPRSEIPDDAVAVRVVAEDLSLSQGDWIAVTPPRVPELQSVQEYVGsDQPVLMDWAVGLAFPCQQPMLHA 975  Mycolicibact...
Q9CDA9         910 -QPKaWRNLRFARSQMPFDAVAVRVVAENLSLTPEDWIAVTPPRVPELRSLQEYVGsSQPVLLDWEVGLAFPCQQPMLHA 988  Mycobacteriu...

7BVH_A         994 YGVVEVPKWRILPDRFGA-EANSPVMDYLGGGPLGITELLLRPSSVPTYLKDDWYRDWGSLQRLTPWYPDAQP-ARLDLG 1071 Mycolicibact...
WP_012832179  1016 NGVLEVPQWRIVPDAVTTnSKSKTWQAAVNGGLLTTPEALTSADTVATYLDHDWYRDWGGLQRLSPLVPDATP-AHVTTG 1094 Gordonia bro...
WP_013128696  1034 NGTYEVPKWRILPTRKDAlSTSSTWQAREAGGLLTVPDTLLKTTTLPTFMTGDLTRDWGELQRYEPIAGDAPQ-AALTVG 1112 Tsukamurella...
WP_013139657   983 DGVAQLPKWRILPDHRLAgTASLSWLGDPGGGLLGIVEPLLDPTTVPTYLTGDWRRDWGSAQRYALIPKNAVP-SAITTG 1061 Segniliparus...
jgi:Tpau_1783  957 GGIAEQPRWRIQPERDLAaAATTTWQGGDAGGPLGWALLLAKAQTVPTYLNNDWGREWGALERYVPYV--AAPqASYGST 1034
WP_013128695   989 DGVAEVPLWRITPDQNLA-PVTTEWEGTLGGGPVGWTQMLLRQEKVPAYLKGDLGQDFGEVMRLVPYSP-ARP-ADLTLG 1065 Tsukamurella...
WP_279102062  1018 VGVAEIPDWRIKPGADLA-AAVTAWQDQFGGGPVGWLQVSQEATALATYLRGDIGRDWGALERYTPYGGVTTL-ADIQTG 1095 Gordonia bro...
WP_014358507  1019 DGVAELPQWRIEPGADLS-AAVSAWQDAFGGGPIGWEQVLLEPTALATYLKGDVGRDWGSLERLVPYDDVTRH-AEITTG 1096 Gordonia pol...
WP_239707514   976 NGVTEVPKFRISPDYYAKlQSTDTWQDGINGGLLGITDLLLRASVMSTYLSQDWGQDWGSLRKFDTVVE-ATP-AELDFG 1053 Mycolicibact...
Q9CDA9         989 NGVTDIPKFRITPDYSAKkIDTDTWEDGANGGLLGITDLLLRAHVMSTYLARDWGRDWGSLRKFDPLVD-THP-AQLDLD 1066 Mycobacteriu...

7BVH_A        1072 TATRSGWWSPAPLR 1085 Mycolicibacterium smegmatis MC2 155
WP_012832179  1095 EKTTWGVSRPGPIR 1108 Gordonia bronchialis
WP_013128696  1113 TQTRSGWWREGPIR 1126 Tsukamurella paurometabola
WP_013139657  1062 EKTRPGWWRPGPSQ 1075 Segniliparus rotundus
jgi:Tpau_1783 1035 EVTRQGWWTPGPTP 1048
WP_013128695  1066 SRTVWGTHVEAPIR 1079 Tsukamurella paurometabola
WP_279102062  1096 TATRSGLWSPAPIR 1109 Gordonia bronchialis
WP_014358507  1097 TATRSGLWAPAPIR 1110 Gordonia polyisoprenivorans
WP_239707514  1054 SQTHSGLYSPGPLR 1067 Mycolicibacterium smegmatis
Q9CDA9        1067 TATRSGWWSPGKIR 1080 Mycobacterium leprae TN
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