7UNG


Conserved Protein Domain Family
PIRC1_2

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pfam14892: PIRC1_2 
Piercer of microtubule wall 1/2
This family of proteins is found in eukaryotes and includes Piercer of microtubule wall 1/2 proteins (PIRC1/2). In mice PIRC1 expression is induced by p53 may play a role in DNA damage response and has been shown to function at the initial step of left-right asymmetry specification of the visceral organs. PIRC1/2 are microtubule inner proteins involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme.
Statistics
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PSSM-Id: 494646
Aligned: 19 rows
Threshold Bit Score: 112.435
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7UNG_z         8 ACAEPVAPKATA-PPERTSDYYRVSADLPGR--FNNPGWFRGY-RTQ-KAVSVYRTSNQAYGSRAPTVHEMPKVFYPNSN 82  human
XP_001372552   8 QSPQQDEEKAEV-YLEKTSDYYRVSKNLPTR--FNNPGWFRGY-RTK-ETHPLYRTTSQTYGSRAPTVHEMPKSFHSTEH 82 
XP_003757510   8 QSSGHNEQKAEEgYLEKTSDYYRVSQNLPAR--FNNPGWFRGY-RIK-ETHPVYRTSNQTYGSRAPTVHEMPKSFHTKSH 83 
A0C7K1        64 TIGLELSQPISE-EEKQR---RKLDNKVPSKkfHVTEQEYKAPpQGInVGLPIYETSNMQYGQLNPTSFELIEKYYPRDA 139 Paramecium tetr...
A0DF20        20 QFGLEQQK------QKQRKRIRKIENKIPQKpfPVRKIKYKNTaQGInVGSPIYETSSMQYGQLNPTKFELIENFYPRDA 93  Paramecium tetr...
B0UXH9        15 ETAGPGDSNTSE---IKTSDVYKVDKNLPSR--FNNPDCFR-Y-SHK-TTNPLYRTTNQAYGSKKPTVHEMPTSFNGSRH 86  zebrafish
XP_006640702   2 entTHTVEEANR-VSIKTSDVYKVQKNLPKR--FDNPDWFQGY-REK-PRNPLYRTTNQIYGGKRPTVHEMPTTFNGSTR 76 
XP_004997018  27 NEGNPVFSASGT---MKTSDLY-ATRNLPER--FDNPGEFKGYgKGKgGENPMYQTSSSSYGLLPPNVHTTPTAFHGLNQ 100
Q0KI89        14 PEVEFAKFQKRK-PVVRTAQLY---ENLHKRedIKCPYSFKGYgVET-DSNTMYRTCNSEYGYYAPNAYTIPKRFYPLPQ 88  fruit fly
XP_064420165  26 QNQTYGNTETEK-PLPKTSDFYRIDPTLPER--FNHPHCFQGYtRKK-QPHPLYTTSNQEYGKNAPTVHEMPTTFKGRSQ 101 coelacanth
7UNG_z        83 KFSQQLAAGGMFRNNTLNVYLEKS 106 human
XP_001372552  83 SFSQHYGACGMYRSNGFNVFTDKS 106
XP_003757510  84 TFSKHYEKCGMYRNNGFNVYTDKS 107
A0C7K1       140 RFTQAFLG-DTFKFDGLNTSTAFS 162 Paramecium tetraurelia
A0DF20        94 KFTQEFLG-HTYKFVGLITSVAFE 116 Paramecium tetraurelia
B0UXH9        87 RFSEHLLKSGMYRDNGFNTMLDKS 110 zebrafish
XP_006640702  77 QFTEYLSKCGMYKDNGFNTSTEKS 100
XP_004997018 101 KFSSHLGQAGMSRNTGLNTAKDKS 124
Q0KI89        89 SFSNEVVRFGMYRNFSLNTHMDRT 112 fruit fly
XP_064420165 102 KFSDFYGKCGMYRDNGFNTCTERS 125 coelacanth
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