1DQ3,2CW7


Conserved Protein Domain Family
Intein_splicing
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pfam14890: Intein_splicing (This model is not part of the current CDD release)
Intein splicing domain
Inteins are segments of protein which excise themselves from a precursor protein and mediate the rejoining of the remainder of the precursor (the extein). Most inteins consist of a splicing domain which is split into two segments by a homing endonuclease domain. This domain represents the splicing domain.
Links
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Statistics
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PSSM-Id: 521516
Aligned: 14 rows
Threshold Bit Score: 228.949
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1DQ3_A           8 IIFENEGEEhltTMEEMYErykhlg--efydeEYNRWGIDvsNVPIYVKSfdpeskrvvkgkVNVIWKYELGkdvTKYEI 85   Pyrococcus f...
WP_012940323   837 IIMHDGCIK---RIDEIFE-------------GEKVLGLN--DFHEKDAH------------VLKFWRIPYKg--TIKEI 884  Archaeoglobu...
Q58907         874 VVLGDGRIE---TIEDIVNa-----------kERNVLSLDldNLSIKIDT------------AIKFWKLRYNg--NLSKI 925  Methanocaldo...
P77933         860 PVLEEGEVHf-vRIGELIDrmmeenagkvkreGETEVl---eVSGLEVPSfnrrtkkaelkrVKALIRHDYSg--KVYTI 933  Thermococcus...
jgi:Mfer_0645   42 ISLAT-GENv--KASELFKkfenkg--riikeEKNEKVIDvdGFGIHVSSldkkenkivkgkVTHLWKLKKTd--PLVEL 114 
Q58815          79 VILPDGRMK---KISEId--------------EDEVLSVNfeDLKLYNKK------------IKKFKHKAPK---ILYKI 126  Methanocaldo...
WP_012409357   396 VTLVDSGLQv--PIKELVGk-----------sGFAVWALNeaTMQLEKAI------------VSNAFSTGIK---PLFTL 447  Nostoc punct...
E7FHX6         309 IIFENEGEEhltTMEEMYErykhlg--efydeEYNRWGIDvsNVPIYVKSfdpeskrvvkgkVNVIWKYELGkdvTKYEI 386  Pyrococcus f...
Q5JJ43         309 IIFENDGEEhimTMAEMYErykdlg--efydpEYNRWGINveEVPVYVKSfdpstkeitkgkVKVIWKYELGedvPKYEI 386  Thermococcus...
Q58242        1067 LIFENNEYKl-vKIGEFVEkylnrykdraityGDNNIEVYikDENIYAPSfdkdgk-ivlkpITHAIRHRGK---EIYEI 1141 Methanocaldo...

1DQ3_A          86 ITNKGTKILTSPWHPFFVLTP-DFKIveKRADELKEGDILI-------G-------------GMPDGEDYKFIFd----- 139  Pyrococcus f...
WP_012940323   885 TLDNNYRIKATPDHGLFVYRDgKFGW--VSAKNIRVGDYVAvafntnvE-------------RRNDLSLLKLLA------ 943  Archaeoglobu...
Q58907         926 TLSNNYELKATPDHCLLVLRDnQLKW--IPAKDIKENDYIAmpfnykvE--------------RKPISLLNLLK------ 983  Methanocaldo...
P77933         934 RLKSGRRIKITSGHSLFSVRN--GELveVTGDELKPGDLVAvprrlelPernhvlnlvelllGTPEEETLDIVMtipvk- 1010 Thermococcus...
jgi:Mfer_0645  115 HLENGNKIKTTPEHKFLVFDN-EEGIieKRADKIKKGDYIVvarklyhE-------------DLTNEELKKKIIe----- 175 
Q58815         127 K-TAFSELITTGEHKLFVV-E-NGKIveKCVKDLNGSELIGvvrklnyS-------------FNDNVEFKDVYVerhykl 190  Methanocaldo...
WP_012409357   448 TTRLGRKIRATGNHKFLTI----NGW--KRLDELTPKEHLClprnlpsS-------------GKQTMTYAEVAL------ 502  Nostoc punct...
E7FHX6         387 ITNKGTKILTSPWHPFFVLTP-DFKIveKRADELKEGDILI-------G-------------GMPDGEDYKFIFd----- 440  Pyrococcus f...
Q5JJ43         387 KTNKGTRVLTSPWHPFFVITQ-DLKIveKRADELREGDMLV-------G-------------GMPSDDDYEFLLd----- 440  Thermococcus...
Q58242        1142 ELESGKKVRVTGDHSVFTIND-NLDVveVKASDLKVGDFIItpkiipsI-------------SKDKIYLSEIVKnkd--- 1204 Methanocaldo...

1DQ3_A         140 ---------yWL--AGFIA---GDG----------------------------------CFDKYH-----SHVKGHEYIY 166  Pyrococcus f...
WP_012940323   944 ----------ELgiTDICVefkENS----------------------------------KLFEKLrekivGIATSTKYKY 979  Archaeoglobu...
Q58907         984 ----------YLdiTDVLIefdENS----------------------------------TIFEKI-----A-EYIRNNIK 1013 Methanocaldo...
P77933        1011 -----gkknfFKgmLRTLRwifGEEkrprtarrylrhledlgyvrlkkigyevldwdslKNYRRL-----YEALVENVRY 1080 Thermococcus...
jgi:Mfer_0645  176 ---------iLSkdEGFIAcvnGDT----------------------------------CKLSFL-----K--------- 198 
Q58815         191 detirnklrkVRekLGLTRkdvEKL----------------------------------CGVKEI-----YIVKIETGKL 231  Methanocaldo...
WP_012409357   503 --------------LGHLI---GDG----------------------------------CTLPRH-----AIQYT----- 521  Nostoc punct...
E7FHX6         441 ---------yWL--AGFIA---GDG----------------------------------CFDKYH-----SHVKGHEYIY 467  Pyrococcus f...
Q5JJ43         441 ---------yWL--AGFIA---GDG----------------------------------SIDKYR-----SHVKGHEYVY 467  Thermococcus...
Q58242        1205 --------kyYVkiKDHIKfieEHE----------------------------------EILKES-----YKEYKTKWKD 1237 Methanocaldo...

1DQ3_A         167 --------------------------------------DRLRIYDYRIETfeiinDYLEKTFG-----RKYSIQKDRN-- 201  Pyrococcus f...
WP_012940323   980 l------------------------------------kNRVIPLKYLIEWnvnlqEVEREAKAiyrqrPSAKKIPIFKln 1023 Archaeoglobu...
Q58907        1014 tstky-----------------------------kylrNRRVPLKYLIEWnfdldEIEKEAKYiyksvAGTKKIPLFKld 1064 Methanocaldo...
P77933        1081 ngnkreylv---------------------efnsirdaVGIMPLKELKEW------KIGTLNGf---rMSPLIEVDESla 1130 Thermococcus...
jgi:Mfer_0645  199 --------------------------------------DKRYDNIEWISH--------EELFSd---gEKLRLPDSTEef 229 
Q58815         232 esieeerlkklcslyginfeeiiyrdnlhytnpvkfpkTPTPELMQIIGY-----IIGDGHFPs---nRMLRLKDERKev 303  Methanocaldo...
WP_012409357   522 --------------------------------------TREIDLAQNVAF------LATEVFGd---sIVPRISPERE-- 552  Nostoc punct...
E7FHX6         468 --------------------------------------DRLRIYDYRIETfeiinDYLEKTFG-----RKYSIQKDRN-- 502  Pyrococcus f...
Q5JJ43         468 --------------------------------------DRLRIYDYTTETlgiinDHLEKTFG-----KRYSLQRDRN-- 502  Thermococcus...
Q58242        1238 lkp--------------------------------vlkKKNAFRLDLIEDlvdkeKIEKISYGha-nyINNKIKLDEKf- 1283 Methanocaldo...

1DQ3_A         202 ---IYYID---------IKARNITSHYLKL------------------------------------------------L- 220  Pyrococcus f...
WP_012940323  1024 adfWYLVG---------LVMGDGTVRDGKVaiaqtdvkkvesivkd-----------------ilpfiqtwtsgmqvfFa 1077 Archaeoglobu...
Q58907        1065 erfWYFAG---------LVLGDGSIQDSKIriaqtplkdvksilde-----------------tfpflhnwisgnqviIs 1118 Methanocaldo...
P77933        1131 kllGYYVS-------------EGYARKQRNpkngwsysvklynedpevlddme---rlasrffgkvrrgrnyveipkkIg 1194 Thermococcus...
jgi:Mfer_0645  230 tkfYYLAG---------IVKAGGNTKLKNIsi------------------------------------------------ 252 
Q58815         304 leeYNQLFktvfnlegnIKKGDGNYYILEInskylidwf-------------------------------renipelfN- 351  Methanocaldo...
WP_012409357   553 ---WYQVY---------LSAAQHLTHSVRNpiakwld-----------------------------------slnvfgL- 584  Nostoc punct...
E7FHX6         503 ---IYYID---------IKARNITSHYLKLl------------------------------------------------- 521  Pyrococcus f...
Q5JJ43         503 ---IHYID---------IKAKGITSHYIELl------------------------------------------------- 521  Thermococcus...
Q58242        1284 ---GYLIG---------AFLSEGHWNDKCVeisstnkefienlveiieeilgkdayyitvkgdkrrykdlyviglnktVa 1351 Methanocaldo...

1DQ3_A         221 ----------EGIDNG-IPPQILKEgKNAVLSFIAGLFDAEGHVS--------N-KPGIELGMVNKRLIEDVTHYLNALG 280  Pyrococcus f...
WP_012940323  1078 nsiiaeilkrLDVRGK-LNGLVFSLpEEWINAMIAGYIDTDGCISlmfdkrtgKhNLRIAISSKDREKLEKVGYYLHSIG 1156 Archaeoglobu...
Q58907        1119 npiiaeilekLGMRNGkLNGIIFSLpESYINALIAGYFDTDGCFSllydkkakKhNLRMVLTSKRRDVLEKIGIYLNSIG 1198 Methanocaldo...
P77933        1195 yllfenmcgvLAENKR-IPEFVFTSpKGVRLAFLEGYFIGDGDV---------HpNKRLRLSTKSELLANQLVLLLNSVG 1264 Thermococcus...
jgi:Mfer_0645  253 --------fkKVVDTLfTWKFIETSpKKYISSFIRGYVDTRGI----------VkNNGIYISSDNE-FIKRLQLLLYKFD 313 
Q58815         352 ----------KTGNER-TPEFVFRLnNDLVASYLRGIFDAEGYIR--------AeAKQIGIGMTSKCFIKEIQFLLLRFG 412  Methanocaldo...
WP_012409357   585 ----------RSYEKF-VPRELFSQpKELIACFLRHLWSTDGCINlia---gkKpRPIAFYASSSERLAFDVQTLLLRLG 650  Nostoc punct...
E7FHX6         522 ----------EGIDNG-IPPQILKEgKNAVLSFIAGLFDAEGHV---------SnKPGIELGMVNKRLIEDVTHYLNALG 581  Pyrococcus f...
Q5JJ43         522 ----------RGITNG-IPQPILKEgRNAVLSFITGLFDAEGHV---------NsKPGVELGMVNRKLIEDITYYLNSLG 581  Thermococcus...
Q58242        1352 mifeslglnkLSSNKE-IPSILLSN-ETFLKGLIKGYIDGDGSIYvd----esKrDYSIRLYTTSETLRDTLCLALKILG 1425 Methanocaldo...

1DQ3_A         281 IKARIRek-----lRKDGIDYVLHVEEYSSLLRFYE----LIGKNLQneEKREKLEKVLSNHKGGN--FGLPLNFNAFKE 349  Pyrococcus f...
WP_012940323  1157 ILNTLH--------EDKRNGVWTLIVSNRSLKTFKE----KIGKYLR--IKKERFERAYEVYTNEH--KQFESDLVPFGK 1220 Archaeoglobu...
Q58907        1199 ILNTLH---------KSREVYSLIISNK-SLETFKE----KIAKYLK--IRKEAFINGYKTYKKEHe-ERFECDLLPVKE 1261 Methanocaldo...
P77933        1265 VSAVKL--------GHDSGVYRVYINEELPFVKLDK----KKNAYYShvIPKEVLSEVFGKVFQKN-------------- 1318 Thermococcus...
jgi:Mfer_0645  314 IASINE------------NNGTLCITGKSSLTRFKK-----IGFSDI--NKKKEFNKLLKKNIDSK------IDHIPVSR 368 
Q58815         413 ILASYSkik--rkeENWNNTHKLLISDKKSFELFKK----YIGFTAK--DKMEKLEAILNKMKGLN------FRYISIPL 478  Methanocaldo...
WP_012409357   651 INATLRtvp---qvGKGRNQYHVIITGKPDLQLFIV----HVGAVGQ--YKLRSLQDIFQHLENSI--HNPNRDIIPKDI 719  Nostoc punct...
E7FHX6         582 IKARIRek-----lRKDGIDYVLHVEEYSSLLRFYE----LIGKNLQneEKREKLEKVLSNHKGGN--FGLPLNFNAFKE 650  Pyrococcus f...
Q5JJ43         582 IKARMRkk-----pRKDGVDYVMHVEEYSSLLRFYE----LIGKNLQnsEKRIKLEELLSKHNGGS--FGLTLSFEDFKA 650  Thermococcus...
Q58242        1426 INYRLSidkkskvnENWRDCYVIKITGKENIEKLLDveikNNGGKDVipKIAEKFKEIINQYSQREwkERFGIDVNNLHI 1505 Methanocaldo...

1DQ3_A         350 WAseygvefktngsqtiaiinderiSLGQWHTRNRvskavLVKM-LRKLYEa-TKDEEVKRMLHLIEGLEV----VRHIT 423  Pyrococcus f...
WP_012940323  1221 LFkllkfkrgik----nkvlkefgiDVWNWNDCVC-----IPREkLRKIVEl-AEDSDIKTFLLELLNANVtwikVKDVK 1290 Archaeoglobu...
Q58907        1262 VFkkltfekgr-----keilkdskiHIENWYKEKTn---nIPREkLKTVLRy-ANNSEHKEFLEKIVNGDIsfvrVKKVE 1332 Methanocaldo...
P77933        1319 ----------------------------------------VSPQtFRKMVEdgRLDPEKAQRLSWLIEGDVvldrVESVD 1358 Thermococcus...
jgi:Mfer_0645  369 EIseiin----------------------------edktsISKHeLRNIFNn-LESKNVKD-LEPLVCDDVsyvkVKKIN 418 
Q58815         479 TKkeirefvg---------vplktiknGDNYCTDYtiekiIEELnSKGLYDk-AEY------LKRFLDADIvwtkFKIEE 542  Methanocaldo...
WP_012409357   720 WKmevvpamqai----gfttrilqaSIGVSYCGSTlykvnLSRErALKVGNi-VQSSK----LVTLAKSDVywdeIVSIE 790  Nostoc punct...
E7FHX6         651 WAseygvefktngsqtiaiinderiSLGQWHTRNRvskavLVKM-LRKLYEa-TKDEEVKRMLHLIEGLEv----VRHIT 724  Pyrococcus f...
Q5JJ43         651 WSskygvefktngsqtlaiiknekvSLGQWHRRGRvskavLVKM-LRKLYDt-TKSEDVKRMLHLIEGLEv----VKEIN 724  Thermococcus...
Q58242        1506 WE-----------------------DLKKGYMSRYrakkvLNIMkNVKEIE--EKYGRLLDKIGQLIDNDLlferIKSIR 1560 Methanocaldo...

1DQ3_A         424 TTNE-PRTFYDLTVEnYQNYLAgeNGMIfVHN 454  Pyrococcus furiosus
WP_012940323  1291 DRYY-NGYVYDVTTT-TSNFFA--NAML-NHN 1317 Archaeoglobus profundus
Q58907        1333 NIPY-DGYVYDLSIKhNQNFIS--NGVI-SHN 1360 Methanocaldococcus jannaschii DSM 2661
P77933        1359 VEDY-DGYVYDLSVEdNENFLVg-FGLVyAHN 1388 Thermococcus kodakarensis KOD1
jgi:Mfer_0645  419 RIND-EKYVYDLTVEkYHNFVA--NGVI-VHN 446 
Q58815         543 VESD-VEYVYDLEVEdYHNFIG--NLII-NHN 570  Methanocaldococcus jannaschii DSM 2661
WP_012409357   791 YSGE-EE-VFDLTVPgLHNFVA--NNII-VHN 817  Nostoc punctiforme
E7FHX6         725 TTNE-PRTFYDLTVEnYQNYLAgeNGMIfVHN 755  Pyrococcus furiosus DSM 3638
Q5JJ43         725 VTNE-PKTFYDLTVErYQNYLAgeNGMVfVHN 755  Thermococcus kodakarensis KOD1
Q58242        1561 VLDEiPEYVYDISVEgTENFIGg-EGFIcLHN 1591 Methanocaldococcus jannaschii DSM 2661
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