Conserved Protein Domain Family
PBP-Tp47_a
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pfam14889: PBP-Tp47_a (This model is not part of the current CDD release)
Penicillin-binding protein Tp47 domain a
This is the first domain in this unusual penicillin-binding protein PBP), Tp47 is mainly composed of beta-strands and is sequentially non-contiguous. The first three domains in Tp47 interact with each other through intimate domain-domain interfaces. Domain A contacts domain B through its N-terminal segment. Domain A also interacts tightly with domain C, Tp47 is unusual in that it displays beta-lactamase activity, and thus it does not fit the classical structural and mechanistic paradigms for PBPs, and thus Tp47 appears to represent a new class of PBP.
Links
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Statistics
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PSSM-Id: 494643
Aligned: 11 rows
Threshold Bit Score: 228.126
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CDA62639       35 DSDYKYVYASLDWAEYWQNENVYL--ASGStlkSSSEEADARGEYDKGAFDVVTRATKNHGLHRGSFQCDAVIRDTDGKA 112 
1_pfamImport    1 KSEYSYVYVGMSWSEYWAKEGVYA--AGDT---GSSSDVDSRNEYDKGAFDAVTRATANHGLHRGSFQCSAVIEDTNGNK 75  
3_pfamImport    1 ETTYKYVYAGLTWAEYWAAEGVQA--AGSD---AGSDETDSREESDKGAFDVVTRATTNHGLHRGSFQCAATIYMKDGTT 75  
CDE44202       42 QEEYEYVYAGISWAQYWESEGIYL---SGTnmvASSSAVDTRGESDKGAFDAVSRATTNHGIHRGSFQCNTTIYGEDGKT 118 
2_pfamImport    1 EEKYKYVYAGLSWAEYWASEGVYL--AEGSnlaSSSDVADKKGELDKGAFDTVSRATTNHGLHRGSYQCTAVIYDTDGKE 78  
CCZ64177      578 apEYTYVYASVPYAEYYANEDVQN--AGSA---ASSDVMDTNGEYDKGAFDTVTRATANHGLHRGSFQQDVVIYDTDGNT 652 
CCZ83255       33 DEDYVYCAAALSWAEYWEQEGVFLsdDANGdwtAESADSDTRGESDLGAYDTVTRATSNHGLHRGSYQCTVKVYDTDGNA 112 
CDE13039       35 TADYVYCYAALTWAEYWQNEGVYLddAADGdlgASSTEKDTHGEYDLGAYDAVTRATSNHGLHRGSYQCTVKVYDTEGNA 114 
CDE53632      153 EDEYTYVYAELTYDEYYAAEPVQN--GDSA---ESSDETDTRGEYDKGAFDAVTRATTNHGLHRGSFQSAVVIYDTEGNV 227 
WP_012738613   34 DDEYSYVYAGLTWQEYWANEGVYN--AGDV---TSSNEKDTHGEYDKGAFDTVTRATTNHGLHRGSYQCMATIDTEDGNK 108  Lachnospira e...
CDD73626       40 DESYTYLYADLNWAEYWAAEDVYL--KDGKnmtDSNETEDARGELDKGAFDAVSRATTNHGLHRGSFQCDAVITADNGQN 117 

CDA62639      113 YEISYWTSEEvsakdengqdttkkvvYAVLTDGS--KIQFD---KGT-----IT--YTENgetKTATMEDYEVKGIKYVP 180 
1_pfamImport   76 YELAYWNADG----------------KAVMSDGSvyTRSTNedkKAV-----FT--AEDG---SSFIQADYKVTGIKYVP 129 
3_pfamImport   76 YDVAYYTAAT----------------TAVLTNGE--TVTYD---KSQ--------------------IDHYEVKGLKYVP 114 
CDE44202      119 FDVSTWKSAS----------------ELVLTDGS--TVGFN---KGT-----IT--YTENgqeKTTTMKNYNVTGIKYVP 170 
2_pfamImport   79 YPVSYWNSSS----------------EAVLTDGS--VITFN---KGT-----IT--YNENgteKTATMKDYEVKGIKYVP 130 
CCZ64177      653 YEPISWTDGN----------------TAILSNGK--TLV-----KASdratgITtlTVDG---KTSTYDHYVIKGIKYVP 706 
CCZ83255      113 YDYTGKGNGEs---------------VDVVK-GD----------NGTm----IT--VDGK---EVGTYDHSMILGPKYVP 157 
CDE13039      115 YDYTGKGQDEs---------------VDVVKNGN----------GGAd----IT--VNGE---VAGTYDHSVNVGPKYVP 160 
CDE53632      228 YEAAGWDGKN----------------TIILTDGT--TVGFD---RGT-----IT--IGE----ETKTMAGYEVTGFKYIP 275 
WP_012738613  109 YELAGWSSDGk---------------QMILTDGT--QLSYN---RGT-----IT--NADG---STSKVSSYEVTGIKYVP 158  Lachnospira e...
CDD73626      118 YPVSYWEQDKdk------------nqSFYTTDGQ--KIGYA---KGV-----MT--LPDA---STTKVVNYTVTGIKYVP 170 

CDA62639      181 VAVKTEDYADFCKKYSVTEDASAIEGGYTENALKAYT 217 
1_pfamImport  130 VKVKTADLNALQEEYAVVENGGTLSGGFSENQLQSYT 166 
3_pfamImport  115 VKVSEDDYEDFCKKYVVVENGGTLSGGFSENKLQSYT 151 
CDE44202      171 VAVKKSDYEAFAAQYPVVSNAGILVGGYSETNLASYQ 207 
2_pfamImport  131 VKVKTADYDEFCKKYQVVENAGTLAGGFTEKNLQAYT 167 
CCZ64177      707 VKVKSKNLEAFKAAYSVTENGETLSGGYSENNLKSYT 743 
CCZ83255      158 VAVPASLYDDFKQKYSVLENGDSMVGGYTEKNLVAin 194 
CDE13039      161 VAVPADEYEAFKEAYTVYENGDTITGGYTEKNLVnin 197 
CDE53632      276 VAVKTSDYEEFKNQYKVVENGETLFGGFSEVNLSAYS 312 
WP_012738613  159 VKVKTSDLADFEQHYRVVKNGEKLYGGFGENKLSSYE 195  Lachnospira eligens
CDD73626      171 VAVKTADLQDFKSKYKVVENGEKLVGGYSENALSSYE 207
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