4OJC


Conserved Protein Domain Family
EFF-AFF

?
pfam14884: EFF-AFF (This model is not part of the current CDD release)
Type I membrane glycoproteins cell-cell fusogen
EFF-AFF was first identified when EFF1 mutants were found to block cell fusion in all epidermal and vulval epithelia in the worm. However, fusion between the anchor cell and the utse syncytium that establishes a continuous uterine-vulval tube proceeds normally in eff-1 mutants and thus Aff1 was established as necessary for this and the fusion of heterologous cells in C. elegans. The transmembrane forms of FF proteins, like most viral fusogens, possess an N-terminal signal sequence followed by a long extracellular portion, a predicted transmembrane domain, and a short intracellular tail. A striking conservation in the position and number of all 16 cysteines in the extracellular portion of FF proteins from different nematode species suggests that these proteins are folded in a similar 3D structure that is essential for their fusogenic activity. C. elegans AFF-1 and EFF-1 proteins are essential for developmental cell-to-cell fusion and can merge insect cells. Thus FFs comprise an ancient family of cellular fusogens that can promote fusion when expressed on a viral particle.
Statistics
?
PSSM-Id: 521513
Aligned: 40 rows
Threshold Bit Score: 472.912
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4OJC_A         48 IGLHTAVCFRLYedtqlasqeindDEnAgNqTSLLHTIRLEKLEHHHPITQRYTFGIPEVHASCICECDATSSTCTAESH 127 Caenorhabditis...
14_pfamImport   1 MGLHDSVCLQIS------------DNtTlTdSSLLHTIQYLRLEQHYPVIGSYKFGIPEVSSTCLCDCAGGDNICDLKKY 68 
3_pfamImport    1 MSLHDTACLSIS------------NNgT-NdTSILHTIQYLRLEQHYPIIGSYDFAIPSVSTNCICDCAGGDQICSLSSY 67 
12_pfamImport   1 MALHETTCLSLK------------VN-D-SeQSMLHTLQYLRLEQHYPITGAYRFAIPSISSKCICDCAGGEQHCNINAY 66 
PAV72324       60 LGLHESACLQLK------------TN-S-SePAFIHTLEYLRLEHHHPIAGKYSFGIPQIKPSCICDCAGGDVTCTLKEY 125
VDN08265       48 LTLKETLCLNFS---------------D-GmTMQIHTIEYVRMEQQFPVSASYKFGIPLITTNCICDCAGAEQYCSVDDY 111
VDN92734       55 LTLKETLCLNFS----------------------IHTIEYVRMEQQFPVSASYKFGIPLITTSCICDCAGAEQYCSVDDY 112
8_pfamImport    1 LTLKETLCLNFT---------------E-SpLPQMHALEFVRMEQHFPVTASYKFGIPQIKSACICDCAGAEQYCTVESY 64 
2_pfamImport    1 ITLKETVCLNFT---------------S-SrTPQLHTFEFVRMEQHFPVVASYKFGIPQIHTSCICDCAGAEQYCSVETH 64 
VDL76911       53 MALHEVACMTIK------------MN-N-SeSSILHTLEFLRLEQHHPVSGIYQFGIPKVTSSCICDCAGGDAPCKMSDY 118
4OJC_A        128 QFTACpesdksdetssCYRTFFPNQTPIGCSEDDIPKLCCDVRFKPYKNMTFLAVKLEQPTTYATFVYAAYDFVNGyWVE 207 Caenorhabditis...
14_pfamImport  69 HYQNCtqg------svCYRTFRPSQSSVGCFNQEKSEVCCEIKIEPFNQWKFTAIKIKQPDTVIIFRYRIFERIKQkWRD 142
3_pfamImport   68 HYKNCtvg------slCYRTYHPSQSNVGCLGSEKSEVCCDVVIEPYNNWNFKAIKVKQPDTILVFRYKIFERIRQrWRL 141
12_pfamImport  67 NYKNCstg------aiCYRTYKAAQSNVGCLSSSKSETCCEVQIDPYKDWAFQALRLNQPDTVLIFRYRIYDKVRKqWRL 140
PAV72324      126 SHGNCtha------siCYRT-HSFVSNEGCLTQGQAEACCDIAIEPYKGWRFTAIKINQPDTWLIFRYSIFSRSAQtWRQ 198
VDN08265      112 KYKNCskg------flCYRTYHSHQSSSGCLMSSKSEVCCEVIMEPYGGKSYTAVKLNQPDTVIILRHRIYERVTNhWAE 185
VDN92734      113 KY------------------------NSGCLMSSKSEVCCEVAIEPCDGRTYTAVKLTQPDTIIILRHRIYERLASrWTE 168
8_pfamImport   65 RYKNCskg------avCYRTFHSHQSNLGCISSARSDVCCEVSIEPYNEKMYTAVQLNQPDTLIVLRHRIYERIAGrWAE 138
2_pfamImport   65 KYKNCskg------svCYRTYHPFQSNTGCISSSRSEVCCEIIIEPAHNKVYTAVKLNQPDTIIILKYRFLERAANrWVE 138
VDL76911      119 HYKNCssg------alCYRTYHPVQTNVGCIGTQKSEACCQLQVDPYKDWTFTAIKINQPVTILVFRYSIFDRFSRrWRK 192
4OJC_A        208 KDKTKIRSQLDGGTQDRHLDQK---RRISLaVTAGGRASHQLETGMYFSRTs-nGgeteELRMQ---PLNEITDNNFDRL 280 Caenorhabditis...
14_pfamImport 143 YSDDTIEVPLDKGIAKFELNNY---HKIEL-SITGSRPNRQLEPGLYFWQH---NepglALRGGv--TLNDIAETSMDKL 213
3_pfamImport  142 SSDDILEVPLNRGGAKFELVNY---NKIEI-TVTGGRPHRQLEPGVFFYQQf-dRfsppIVKGNi--PINDINENSLDKL 214
12_pfamImport 141 SADDVIEVPLNRGSSKFKLNNN---HRMDI-VVGGSRPHRQLEPGMYFMKEdstR----DLRGGa--PINDVFESNLDKL 210
PAV72324      199 ISSEIIKVPLNNGIARFQFNQI---HHIEL-SVSGGPTNRRVEPGMYFVREg-sH----ELHGGtltPLNDLTETHMERL 269
VDN08265      186 AASEEFEAVVNKGSAKMETIDK---RKMEI-RTTTGRAIREMYNGMYYFSNdn-----rALMMGv--RLNEPTETDIHKL 254
VDN92734      169 AASEEFEAVVNKGSAKMETIDK---RQMEI-RTTTGRAIREMLNGMYYFSNdn-----rQLMMGv--RLNEPTESDIHKL 237
8_pfamImport  139 TASEEFDVVINKGSAKIESIDRqrvRLVEI-RVTSGRAIREIYEGMYYYSDdd-----rLLMMGv--RLNEPTENDIHKL 210
2_pfamImport  139 MLSEEFEAIINKGSAKIENIDG---HKTEI-RATSGRAIREMTEGLYYFWDek-----rVLMSGv--RLNDPAESNIHKL 207
VDL76911      193 ASEEVVEVPLNLGISKFDFNNV---QKIEM-VVSGSRPYRELQPGMYFLRDg-tH----ELRGSv--PVNDLGESSLEKL 261
4OJC_A        281 GWYRM------DDsGHFHVNNGVVKMDDIHKAKVKNCKEQTYKSILSANHYMp--------GHFNLTRPLEViKPWIQSA 346 Caenorhabditis...
14_pfamImport 214 GWMRY------EK-EEWSVRNGLVKLTQAQHINVLDCKNQKYISTINGEQLVvsgd-nklmESYNLGSLIIE-DPWVKAV 284
3_pfamImport  215 GWMRK------ED-GKWNVRKGQVKITQAQHINVQDCKLQRYLSTLNAEQYVsvgdgnekdENINLGNLLTD-ETWLESV 286
12_pfamImport 211 GWMRWeipagtSE-GRWDIRKGMVKVTQAHHVNVEDCKGQKYTTNFNGEQMVvsgd-egesENIDLGRQIQA-DPWIQSV 287
PAV72324      270 GWMRF------NDeGKLAIYNGDTKIKIAHSVRVINCVKQEYETKFAGREYVldtg-krvtENFDLGKALTE-ESWIKTA 341
VDN08265      255 GWLRK------NG-TSWLIRNGIIKITDSQHITVENCKEQRYLTRYNAEYFLtyg---driSDLDLGHQVDE-QNWVERA 323
VDN92734      238 GWLRK------NA-NSWLIRNGIIKITDSQHVTIENCKGQRYLTRYNAEYFItsd---driTDLDLGYPVHE-QNWIEQV 306
8_pfamImport  211 GWFRK------QD-GIWAVRNGIVKITDSQHVTVEDCKGQKYLTRYNAEYYTtds---dgiIGLDMGYRVDA-QVWVNKV 279
2_pfamImport  208 GWLRR------EE-GIWVIRNGIIKITDSQHITIENCKSQRYLTRYNADYFLtds---ndiSQMDLGFRVDE-LSWVERV 276
VDL76911      262 GWMRY------TD-GKWDIRNGQVKIKQAHHVNVENCKQQLHKSTLNGEQLVyvsg-devvEEFDLGRALTS-DPWIETA 332
4OJC_A        347 RIfdsslRQAVVTHAEGTNLQISIHldDEvesQNLVFFHNASRIRDFSGSIIVDSKSNRLFNLTVYEASGKIDGSVKMST 426 Caenorhabditis...
14_pfamImport 285 SVid--sRFVKIEHGEGTGIVGSIK--TE---FKPLMLTHSSQFESFNGTLQLDKYSNRFMNVSFFEAKGTLIGTIFSSE 357
3_pfamImport  287 SVke-dgRVMKIVHSEGIGILGSVK--TE---FKPLMLTHSSQFASFNGTIQLDKESNRFLNITFHEAKGTVIGMVYSSE 360
12_pfamImport 288 DVg---tRVVKVEHAEGTNILISLT--TV---SRPQILHHSSQFSAFNGSVQVDRESNRFLNITFQEAKGTLIGQLYSSE 359
PAV72324      342 RVe---sRVVVVEHGEGSYVNIDVL--TE---TRPQILKHPSQMQNFSGLIQLDRESNRFLNVTFFGVKGTLIGKIYKSE 413
VDN08265      324 EIsg-ddRAVRIVHAEGSVIRVSVS--SG---ARQ-------------------------------GGKGTLIGYVYRSD 366
VDN92734      307 EIln-dnRAVRIVHAEGTVVHISVS--SD---TRPIIVRHASHLLTFNGTIRMDDQSNRFLNLTILGGKGTLIGYVHRSE 380
8_pfamImport  280 SVaa-dgRSVRIIHGEGTAVHLTVS--SE---TRPLIVQFSSQVQSFSGAIQMDENSNRFLNLTIQGGKGTLIGYVHQSE 353
2_pfamImport  277 LIss-ntRSIRVLHAEGTVVHLTIT--TD---KKPLIVQHTSQIRSFDGFLRMDDKSNRFLNLSLIDVKGTLIGYIHQSE 350
VDL76911      333 VYe---gRFVRVEHAEGTTISVHMT--SE---IRPHMLRHISQLESFDGMIQVDRDSNRYLNVSFTGSKGTLLGSIFSSE 404
4OJC_A        427 GFGSDtIHTFTAYVsdlhasNRSMIIpLPAIVGQGARAICLRADSMaDiDKICHVIEYFESPLEIDLVEGKWHEMIGTCP 506 Caenorhabditis...
14_pfamImport 358 AKDRG-DLSFSVQIdgtstrDYNFNV-AVPPSVNGSRYVCVHPSGDyM-GQHCVWMTFNEVPLETFTISNHWISDQAECH 434
3_pfamImport  361 NKANI-DIVFSVLIdgtstrEFNCII-TVPGSVNSSRYVCFHPAGDvR-GQQCSWLQYKSVPIPVYTVPHRWVSGKGDCE 437
12_pfamImport 360 ERQHM-DIVFSVQIdgpttrSFNAIV-SIPSSVNSRRYICFHPAGDvD-GQMCKWFEFKEDPLPKYKVAHRWQTGPADCA 436
PAV72324      414 TKTEP-EMTFSVQTslsktlDQLSII-SVPASINGKRYVCFYPASDlK-GEICKWFNYDSQPLHSYKALNPFEMQVGDCH 490
VDN08265      367 DKSTT-DWSFSIEIgtatrtKFMATVgGIPSGIISDRYVCLQPAGDaN-AEQCKWLKYEASPLRERHMAHRWQAGIGNCP 444
VDN92734      381 DKSST-DWSFSIEIgtatrtKFTATIgGIPTGIISDRYVCLQPAGDaS-AEQCKWLKYEASPLRERHVAHRWQAGIDNCP 458
8_pfamImport  354 DKSIT-EWSFSVELgasirqHFRTTVgGIPPDINSDRYVCMHPSGDiF-AEICKWLRYDSRPLRERHVAHHWKTNIGECP 431
2_pfamImport  351 EKTKT-EWSFSVEVgsflkhHFITTIgGIPPEINNDRYVCIHPAGDiN-AEKCKWLQYEADPLRQVRYTPRWQIGIGDCP 428
VDL76911      405 KKDQI-DMAFSVLVds---kNQRSII-SIPSTINSSRFVCFHPSGDvE-SEICKWFRYETQRLNSYRVAHRWATGRGDCA 478
4OJC_A        507 TCNQINFNGMMKFLNPAHWIK 527 Caenorhabditis elegans
14_pfamImport 435 GCNEFTIESIIEKLDPQKMWK 455
3_pfamImport  438 NCNERGVDYFTAKLDPRTWFK 458
12_pfamImport 437 GCNEIGVENFIEKMDPRKWLD 457
PAV72324      491 GCNARGLEGYLVSLDPRSWLN 511
VDN08265      445 GCNERGIENFLLKLDPRQWLD 465
VDN92734      459 GCNERGIENFLLNLDPRQWLN 479
8_pfamImport  432 GCNERGFDNFLQKLDPRQWFD 452
2_pfamImport  429 GCNERGFDNFLQKLDPRQWLN 449
VDL76911      479 GCNERGVEHFLTSLDPRQWFN 499
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap