Conserved Protein Domain Family
DUF4487

?
pfam14868: DUF4487 (This model is not part of the current CDD release)
Domain of unknown function (DUF4487)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.
Statistics
?
PSSM-Id: 521505
Aligned: 19 rows
Threshold Bit Score: 525.817
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_015690770  229 VILLNISWKGIISLLQL--GKGTIEGKVNVREIILIPISIAIESLRIATET--W----CVPLQEVLGTTEAR---RAFLP 297 
XP_023810320  228 IALHANTWKFLIKQSLK--HRPLVEEHLRHGDLSSSLCDNLLTSFHNCVEL--AeqiqHAGLQDSTQSTEYKlfqKTAKM 303 
XP_014326801  228 IALHANTWKFLIKQSLK--YQSLVEEQLHHGDIVNSLSDNLLASLQSCVEM--AeqikLAGLQETVQSPEYKlfqKTAKM 303 
4_pfamImport    1 VALHANTWKFLIKTSLK--YQSLVEEHLHHSEISNSLVDNLLTSFHNCVEL--AeqikHAGLQEATQSPEYKlfqKSAKM 76  
XP_004348155  210 MSMLNATWKALIRLVSRa-APTALRSNIPIGAIVDALSAPLLRNLKDCVTAtpYtvtgQTPDEPATSFGDSKnftRCFRV 288 
XP_006854270  262 VSILNVSWKGVVTLLQLevGKAILANKINVEDIILTLVSLARESLKCTAEA--W----ALPFKGSLSVTEAK---RSFLP 332 
1_pfamImport    1 VTILNLSWKGVVTLLQL--GKGALAVKVNVPDIILTLISLANESLRCAAEA--W-----SSRTETITAAEAK---RTFLP 68  
5_pfamImport    1 VTILNTSWKGVITLLQI--DKQTLASKVDVGEIILKLISLIKESLRFSAVA--W----SCSVKENISATEAR---RVFLP 69  
EEF44288      154 VTVLNVSWKGVVTLLQQ--GKEVLTEGVSVQDIIVTLISLVNEPLKCAAVA--W-----SSLEETISMTEAR---RIFLP 221 
2_pfamImport    1 IALHANTWKFLIKHSLK--YQSLVEEHLHHGDISNSLCENLLVSFNNCVEL--AeqikHAGLQESTQSPEYKlfqKTAKM 76  
XP_015690770  298 IKYFLMNAVRICSIYPSEAMAIYKNIIRCALVISYSsi--lFCRNPQLKAASELVFELLEPSSFL---LLDTLMKSPEVS 372 
XP_023810320  304 CRFFANTLIHYIKEFKYFLTKYCSRFHQLYLQIITK-----FPPSLCAPALPAALSGELSAAAAV---PMDAFLLQLLPL 375 
XP_014326801  304 CRFFANTLVHYIKEFKYFLTKKSSCFHLLYLQIFSK-----SPPSLCAPSLPTALAGELSASALV---PMDAFLLQLLPL 375 
4_pfamImport   77 CRFFANTLIHYIKEFKFFLTKSCSCFHQLYLQIMSK-----FPPSLCTPELPIALSQELNAAALV---PMDAFLLQVLPL 148 
XP_004348155  289 CRFYLSHLFHTVKALASSLESCYAKVIDIVLSVKGLildalTSKNVTAVTFSELRSLVINADTIVkclAINPLFCACLGS 368 
XP_006854270  333 IKFYLINAVRICSRYPCEASKVFKDIMFCVLRISTLgl--eLRKETNLGTASDALAEFLEPTSFL---LIHTLLNSLELE 407 
1_pfamImport   69 VKFYLINAVRISSQYPCQAYLVYREIILCVLMILTLgi--sLSIEKHLKTASEVLAELLEPTYFH---LLNALLNSAQVK 143 
5_pfamImport   70 VKFYLINAVKVAALFPNQVSMVFKEISLCILMISAFkv--sLSQQTHGKYASEVMTDLLEKTTVD---LLNALLNAGEIT 144 
EEF44288      222 AKFYLINAVKISSFYPCQAYLVYREVSHCVLMISTFri--lLSFQKLLNTASEVFSELLEKTSID---LLTSLLNSTEVN 296 
2_pfamImport   77 CRFFANTLVHYIKEFKFFLTKYCNCYHRLYLHIISK-----FPPSLSAPTLPSALSEELSAAALV---PMGALLLQLLAV 148 
XP_015690770  373 PESKCQLVEYLLEKvetnnpentgqvdhrmnf--aslgcifsvdsdgdninRAL-LPAEFTVFLHLLNASPWLTEEV--- 446 
XP_023810320  376 GQFADVVLQVDLQL-------------------------------------NPDqELPHCLLLASIMGQLTSQPEEVlql 418 
XP_014326801  376 RPFAEVVLQPDVWL-------------------------------------SSEhELPHFLMLVNILGQLLSQPEEVmel 418 
4_pfamImport  149 RPFAEAVLQQDLRL-------------------------------------SPEhELPHCLLLVSVMGQLAGQPEEVlql 191 
XP_004348155  369 SCQSDAIAGRPL-------------------------------------------RLAQLTTVLALCTFSTDTRDPLpat 405 
XP_006854270  408 NECKLQILDSLFPIdvakqsmksegdicsidnekiapdealasncedipsmRNL-ILGRVFVLVNLLKNSPDLGEEV--- 483 
1_pfamImport  144 QELKFQILDWLFIDehnsnssvgdpstsywt---asmdtiftvsceampgaQIL-LLSRVALFLNILKSSRDLEEDV--- 216 
5_pfamImport  145 QELRLSLLDSLFIDeqcfptqvcnkqghgsqt-epslvdilslsvesaasaRGL-LLARVVLFQAVMRYSSELEEDA--- 219 
EEF44288      297 QEQKLELLDWIFADeccsnsfhgdlssfyhl---nsmveifsvssesipqeRLL-LLGRIALFHTLLRYSIYVEEDV--- 369 
2_pfamImport  149 RPFAEFVLQNDLRL-------------------------------------SPEhELPQCLLLLSVLGQIHSQPEEVlql 191 
XP_015690770  447 ---------------VIELCKKLHPLLNILILEDvysyVLGCQIPALSGAEDAPGVVwqPIYTSLIQALKTFMIaaSASS 511 
XP_023810320  419 wfags---qfpeetpRLPLYKAIFDSFRRCDVER----KVPVLLPGVMLKGQAQARV--SLHRHICVQLCASIA--ALPP 487 
XP_014326801  419 wysgs---qfpedtpRLPLYQAIFISFRQCYTER----KVPVRLPGVMLKGQAQVEV--TLHQHICVQLCASVA--VLPP 487 
4_pfamImport  192 wyagn---qfseeniRLPLFQAIFTSFRRCYTER----KVPVLLPGVMLKGQAQVQV--TLHQHICVHLCASVA--WLPP 260 
XP_004348155  406 vldllfpnaaadqqsALPLLDMVFAQVAEARAEIllpcTLYVEVPGAVPSSEQAQLLrvSLYQHTWESLCDLAV--ALPA 483 
XP_006854270  484 ---------------VFMLSKKLDWLLDAFINENvysfTLLTQIPQVSGLTTSPEIAvqPMFYYILNSLKTFMIv-ASSS 547 
1_pfamImport  217 ---------------RLGIARKLGWLLDVLVHEEvyssVLVLQVPILYGSGQTLELVwqPMFSSLILSLKTFMIv-VSPS 280 
5_pfamImport  220 ---------------KLAITRKLQWLLDVLTDEKvytsVLSSQLPMADGSGKT--IVweSMFSALLLSLKTLMIt-LSSS 281 
EEF44288      370 ---------------RNKLTRKLGWLLDILVDEEvyssFLDLQILVSYGCGKTIELVwqPIFSSLLDALKTFMIl-VSSS 433 
2_pfamImport  192 whtgs---qfseeepRLPLYQALFTSFRRCCAER----RVPVLLPGVMMKGQAQVLV--TLHSNICVQLCASVA--ALPP 260 
XP_015690770  512 AAWSDFEVFLLENLFHPHFLCLGILTELWCFFVHYAETEASTYLINQLLILLKTLASPDEVFaplSSLRKLARALCTILS 591 
XP_023810320  488 KHFPMLERCLIDAVLQADTQTALLATDAWCFTARYGSAELCFHHVLLVAQLVKTCPTECYRM---SHLGILLKRLVFLMT 564 
XP_014326801  488 VFFPVLERCLMDAVLQADTPTALLAVDVWCFTARYGTAEVCLHHVLLIAQLVKACNSECYQL---LHLGLLLRRMVFLMT 564 
4_pfamImport  261 EYFRVLECCLVEAVLQADTQTALLAADVWCFTARYGTAELCLHHVLLIAQLVKACATDCYQS---FHLGMLLKRMVFLMT 337 
XP_004348155  484 AKFSVLERALMRQVLSPNSLCATLAADVWSFLAPRLPAHTLCAHLRLLGQLIVCTPRDQPLH---VTLGHLISRLSSELP 560 
XP_006854270  548 LAWLEVEKFLLCNVVHPHPLCSEIVTELWCFLAQHAERDLLNDTVDKLSSLIWTLASSGQGPipsSALRKMARSVCIVLN 627 
1_pfamImport  281 PMWSEFEFFLLQNFFHPHFLCWEIVMELWCFMVRHAEIEMVVGIIDKLCSLLKSVASIQPVLapsCPLRKMARSICKILS 360 
5_pfamImport  282 PAWEELETLLLKNLLHPHFLCWQIVMELWCFWARHATDVTVANVIDKLCIFMLSMSTSEAPLcpdSVLRRTAKSICFLLT 361 
EEF44288      434 SGWVEMEAFLLENLFHPHFLCWEMIRELWCFWSRHAESDMVNGILDKFLSLMKLLASPESVLihaSPLRKIARIICSLLM 513 
2_pfamImport  261 VFVPVLERCLLNTVLQSDTQTALLATDVWCFTARYGTAELCLHHVLLVAQLVKCCPAECYQS---SQLGLLLRRMVFLMT 337 
XP_015690770  592 YASPATIDQIYTCALNDnsyes---silylALLMEGFPF--ESLSVGTKELALKTLFTAFAGYLqkQNYLNNHGEIDLpt 666 
XP_023810320  565 PKHQEQLVEHFPPSELEn------------RAVWDNILF--GALSQDTRLRVEADMISLAQNAL--TDWRNGGYKMVQ-- 626 
XP_014326801  565 PSHQLELVAEFSPSKVEn------------LPVWHHVLV--RALSQDVRLRVETEIIALMQRTL--MEWEDGGYKLGQ-- 626 
4_pfamImport  338 PNHQMELVSHFPPSEVEn------------LPVWHHVLL--RALSQDICRQVVTEVTGLTQKML--TDWQNGGYKLGQ-- 399 
XP_004348155  561 DDQYIALVEAFSPAANLa-----------nLAFWRYFAAsgQAMSEQEIAVVQAGVSSIVSGVVapatqalvq------- 622 
XP_006854270  628 CTPQSAIDRIYGSFFGEdnarngasvalhlALLMEGFPL--DSLSENLRKLAVRRVLTAFCGFI--ESNSKN-----Lvd 698 
1_pfamImport  361 SGTESIVDQVYSSIVGDdrsqls--lvmhiALLMEGFPL--NLLSDSMKSIATRRIMTDYFGFI--DSFDDK-----Tlq 429 
5_pfamImport  362 HSPKSLTAQVYKNISTEsrsesa--pdaylALLLEGFPL--NFLPDRMISDAKKQIVAEFFHFI--ENFTEK-----Tsn 430 
EEF44288      514 NGSSSIVDHVYSSVIGDgkshws--svmyiALLLEGFPL--NSLSDNLRSIAKQKIVTDYFSFT--ATSSHK-----Lst 582 
2_pfamImport  338 PDHQTELVERFPPSEVGn------------LPVWRHVLL--RALSQEARRRVEADITDLTEKAL--SDWRSGGYKLGQ-- 399 
XP_015690770  667 ssssgvvglpvhal--asalqsceikdtitvnEKSIATIFKIAISLINMYRtspdGS-KNLLVQH--------------- 728 
XP_023810320  627 --------------------------------VDQVNVALSALLSVVRGQL----SPtAQPAVEMitevwlrmspa---q 667 
XP_014326801  627 --------------------------------VDKVNAALGSLLSLLRGHPsp-eEQcSLSVLRMitqlwsrmnps---q 670 
4_pfamImport  400 --------------------------------VGKVNAVLMSLLSVVRGQSap-eEQcVLSSMRIvtqlwlrmspd---q 443 
XP_004348155  623 -----------------------scqpnqgasVHEIQTLACGAIATLFTSHaiasTIaRRDLTTLidtivrcsasvfpaa 679 
XP_006854270  699 rsstsipglhgepvyalsslfshnqikgheidNKYIWPILRFTMTVIHGFKsitdTSkKDQYIQF--------------- 763 
1_pfamImport  430 acssgvfglpvfal---saalqsievktsdidTK----TLRFLVAIIQKYRssmdNLmKDHCRKL--------------- 487 
5_pfamImport  431 ssryfvqggpvval---saclgilkmsipeidSR----TLKFGVALIQKLRkskdEMtRDRYTEI--------------- 488 
EEF44288      583 tcssgvfgfpvftl---saslqsqqvsisdvdMK----SLNFLVTTIRNFKnavhKLmKEHYHKL--------------- 640 
2_pfamImport  400 --------------------------------VEKVNKVLFALLAVVRVQSsp-eEPcVLSATGVitqlwlrmspd---q 443 
XP_015690770  729 ----------ISSILVIITHMRHLCAFSELEKLTLELHTLFMSGPDNsIaaIsqcKPSMASFMAILGHLNTTEDDANILC 798 
XP_023810320  668 vqscpvlqdtLQLLLSVTAALVKNAEPHVLCQALSCLDAVVSGTCPD-H--L---LLAALDFLSSMGKVFVPPESQSPVL 741 
XP_014326801  671 lqthlvlqdtLKLLLSATTVIVKNIKPETISQGLLCLEAVVSQKCPD-Y--L---LLAALGFLSSLGKIFFPEDCQGQIL 744 
4_pfamImport  444 lrthpvlqwtLQLLLSLSAILVKHIEPHIICQALVCLDDVVSQKCAD-W--L---LLAALEFLCSLGKIFVPPDSQSQIL 517 
XP_004348155  680 gsgeapaqacCALLNAVHA-LYPGLSVDHLTSIFTALAASIERQPLGv-------KLIVCKLLGRCAHFSVEGLRQPHAS 751 
XP_006854270  764 ----------LGQTLEIISHIKQAYACDQMHELVSELLSLFTAYTTIsDgqLhlcKPALAAFLAGLSHMEISEGEECPSS 833 
1_pfamImport  488 ----------LSETLGIVSNMKHLYASDAMEEVILELQNLFISGQAAsDtqLyecKPDLASFLAGLAYMKIVESDKNAKS 557 
5_pfamImport  489 ----------LSETLSIISRSEQLYTCQEMDNVITELQRLFITETDNsQhhLhklKPSLALFLSGLSNYEMSETETCPKS 558 
EEF44288      641 ----------LNETLGIISNLKHLYKSDEIEEVILELQNLFISGPAAsDplLyqcKPYLLLFMGGLGDMDMSESDNCAKS 710 
2_pfamImport  444 vqthpvlqwtLQLLLSITAILVKSLDPQVIYQALLCVDKVVSQKCAD-Q--L---LLAALEFLSSLGKIFFPPDSQNPIL 517 
XP_015690770  799 SAMWD----LFHFLLRERHWALIHLVVGSFGYFAARTSFAQL 836 
XP_023810320  742 PKLSG----LFGVLLADKSWLVQQHALEAFSFFAENTNHEEV 779 
XP_014326801  745 PRLSG----VFGALLADKSWLLHQHALEAFSYFAGNTNHEEV 782 
4_pfamImport  518 PRLSS----LFGVLLAEESWLLHQHTLEAFSQFAENTNHEEV 555 
XP_004348155  752 PELLQawihLFNVVLSEQHWLVLTPACVAWQEFAQFTPFKDI 793 
XP_006854270  834 RAIWE----LYHNMLREKHWALVHLGLAAFGNFAARTSCNQL 871 
1_pfamImport  558 SAVWE----LYRMLLSERHWAFVHLAITAFGYFSERTSCDQL 595 
5_pfamImport  559 RAVWE----LYHLLLRKRHWALVHHAVTAFGYFCARTGCAQL 596 
EEF44288      711 CAVWE----LYHMLFKERHWALVHLAIAAFGYFAARTSCNQL 748 
2_pfamImport  518 PKLSS----LFAVLLADGVWLLQQHALEAFSQFAEITNHEEV 555 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap