Conserved Protein Domain Family
Scorpion_toxin_alpha-beta
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pfam14866: Scorpion_toxin_alpha-beta 
Long chain scorpion toxin, cysteine-stabilized alpha/beta domain
This entry includes long chain scorpion potassium channel toxins and and scorpine-like peptides, which exhibit strong antimicrobial effects as well as cytolytic activity against eukaryotic cells. Thi is the cysteine-stabilized alpha/beta (CS-alpha/beta) domain, which is more closely related to invertebrate defensins, than to the classical scorpion toxins. Its structure shows an alpha-helix along with one beta-sheet stabilized by three disulfide bridges folding into a CS-alpha/beta motif.
Links
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Statistics
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PSSM-Id: 259003
Aligned: 13 rows
Threshold Bit Score: 57.8525
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9NJC6   30 KNIKEKLTEVKDKMkhswnkltSMSEYACPV---IEKWCEDHCAA-KKAIGKCEDTECKCLKlrK 90  Chinese scorpion
A9XE60   37 STLRTVLQTVVHKV--------GKTQFGCPA---YQGYCDDHCQDiEKKEGFCHGFKCKCGIpmG 90  lesser Asian scorpion
Q0GY44   36 DTLRSIMKTIVHKL--------AKTQFGCPA---YEGYCMNHCQDiERHDGSCHGFKCKCEK--S 87  Tityus discrepans
P0C2F3    9 DQLRSILKAVVHKV--------AKTQFGCPA---YEGYCNDHCNDiERKDGECHGFKCKCAK--D 60  Tityus stigmurus
Q0GY45   33 GKIKDKLIEAKDKIksgwerltSQSEYACPA---IEKFCEDHCAA-KKAVGKCDDFKCNCIK--L 91  Tityus trivittatus
C7G3K3   28 QRVKNAASKAYNKLkg----laMQSQYGCPI---ISNMCEDHCRR-KKMEGQCDLLDCVC----S 80  Liocheles australasiae
Q0GY41   27 QKLKKKLNQAVDKVke----vlNKSEYMCPV---VSSFCKQHCAR-LGKSGQCDLLECIC----S 79  Hadrurus gertschi
ABR21074 30 SNLKEKLSGVKEKMknswnrltSLSEYACPV---IEKWCEDHCQA-KNAIGRCENTECKCLS--K 88 
D9U2B1   28 DKVKKVFSKAKDKIlagvedlnNMSELGCPF---IDKWCEDHCES-KKLVGKCENFDCSCVKlgG 88  Chinese swimming scorpion
C6ZH27   24 TEILDKVKKVFSKGiagvadlnNMSELGCPF---IEKWCEDHCES-KKQVGKCENFDCSCVKlgG 84  Chinese swimming scorpion
Q0GY43   33 GKIKNKLVEVKEKIkagwdkltSKSEYACPV---IDKFCEDHCAA-KNAIGKCDDFKCQCLN--S 91  Tityus discrepans
D9U2A7   39 GIVKNLLQAGIHKV--------AKMQYGCPI---IKDYCSFHCNDlEKHEGYCHGTKCKCNIpnQ 92  Chinese swimming scorpion
Q0GY40   38 GIIRNAAKAIVHKM--------AKNQFGCFAnvdVKGDCKRHCKA-EDKEGICHGTKCKCGVpiS 93  Hadrurus gertschi
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