Conserved Protein Domain Family
Hce2

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pfam14856: Hce2 (This model is not part of the current CDD release)
Pathogen effector; putative necrosis-inducing factor
The domain corresponds to the mature part of the Ecp2 effector protein from the tomato pathogen Cladopsorium fulvum. Effectors are low molecular weight proteins that are secreted by bacteria, oomycetes and fungi to manipulate their hosts and adapt to their environment. Ecp2 is a 165 amino acid secreted protein that was originally identified as a virulence factor in C. fulvum, since disruption reduces virulence of the fungus on tomato plants. We have recently determined that Ecp2 is a member of a novel, widely distributed and highly diversified within the fungal kingdom multigene superfamily, which we have designated Hce2, for Homologs of C. fulvum Ecp2 effector. Although Ecp2 is present in most organisms as a small secreted protein, the mature part of this protein can be found fused to other protein domains, including the fungal Glycoside Hydrolase family 18, Glyco_hydro_18 pfam00704 and other, unknown, protein domains. The intrinsic function of Ecp2 remains unknown but it is postulated by that it is a necrosis-inducing factor in plants that serves pathogenicity on the host.
Statistics
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PSSM-Id: 521499
Aligned: 88 rows
Threshold Bit Score: 63.1091
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EMR64545      47 LCGE-STFE--DKTNhdksPLTADCEKVISELAAHdnsvvygGGWAPDE--------------ENIEQYvgahtaGTCTF 109
EMR69367      64 YCGA-TSFAavSDIDas-aDWTDGCASIRDSVLSDp------RDFLLADyst--------aefNTLLSD------GGCAF 121
EMR66681      79 YCDLsQAFGreDDYIgl--gtVEDCTTLRDYMLETd------GAFLLGPdgll------pgyyTGLIGH------NTCVV 138
XP_003001398 312 RCHPiTAQKqtKDLL----ARTDDCRELVSVLAHPsw----nGYWLFSHddvqwc---hkgfgTAIIQL------GTCVF 374
XP_001907155  22 NC---QSYTadVRETlwnsPTEMDCYAIQATGESQe------CTYKASDg------------qVQLAAS------ASCHL 74 
CCE29729      44 TCGT-STFV---ESTnldpANWRECASLYSSWMSQn------GTFYLRNvda--------tgfTPILRT------KDCAL 99 
5_pfamImport   1 TCEP-SSFS---QGPipnaADWRVCAALLSAWASEn------GTFSIRDasg--------sawIPVLKS------EGCTL 56 
XP_013961036  40 TCDP-SSFS---QAPiddaADWRFCAALSSSWASEn------GTFRIHDvsg--------stfIPVLKS------EGCVL 95 
XP_013942925  40 TCDP-SSFA---QAPvsdaADWRFCAALSSAWSSTn------GTFSIHDvsg--------snyMPVLKE------EGCTL 95 
EWY96101      54 TCDK-KTYNahQAPKstkrANYRDCAALLSTFGTRn------GTFSIPAasddkreygvgdglVNIVKS------GSCAF 120 Fusarium oxyspo...
EMR64545     110 GFRPQAYGSTYYk-vGYTDIVDVMRDALARFG-DGQR----VGAAGRFDC 153
EMR69367     122 QVKPQTPPTSDPiyfGGTDITDVLKSAVDQSQgGS------VGVGGSMTC 165
EMR66681     139 SVGLDIAAPFDGlwvGNKDVADVLTLALENYVkDDGM----LFTEGYWPC 184
XP_003001398 375 SACPVARIGM-----GNEDIKRFIQSGIDKVA-SGDN----MRVTGEGGC 414
XP_001907155  75 QVRVNGDGNEITf--GNQDAAEIVKLAISKYQ-ATLDgvlrVGGQGTVTC 121
CCE29729     100 GVQPADASKRSFn-iGDQDLKMLLATSLQQFS-EGTN----LRVSGTVKC 143
5_pfamImport  57 GVKASEQGQGPYi-vGDEDVKAIFNIALEYYS-EGTD----LSVEGNVKC 100
XP_013961036  96 GVKASEQGQGPYt-mGDQDVKAILRIALQDYS-EGTD----LSVEGSVKC 139
XP_013942925  96 GVKASEQGQGPYt-mGDQDIKAILRIALQNYS-DGTD----LSVEGNVKC 139
EWY96101     121 AVRADKGLKV-----GDDDVVWIMQKAVLEYS-AGTE----MAARGSVKC 160 Fusarium oxysporum NRRL 32931
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