Conserved Protein Domain Family
INTS5_C

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pfam14838: INTS5_C 
Integrator complex subunit 5 C-terminus
This family of proteins represents the C-terminus of subunit 5 of the integrator complex involved in snRNA transcription and processing.
Statistics
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PSSM-Id: 494603
Aligned: 9 rows
Threshold Bit Score: 735.759
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003970284  257 KIGSVVGILGHLAAHHSDSIRKELLRMFQ---ESLNPSSpl-spTSsstswessPQLRRAAVPFLLQLAAMSPNLFGAVS 332 
XP_002430577  227 KLNSVVGILGHLASSHFTDIRKALLELFE---WIFDDSN-----AD--------LQYRSAVIPFLLQIASKSQTLLKALS 290 
1_pfamImport    1 KLNSFIRILDHLSITYFNNIKDVVFKLFK---LSLGEEHq----KM--------TIENIAIVPFLLHMAMCSSTLLKSML 65  
3_pfamImport    1 KLKSVVGILIHLSGSHRTEIKKAMSDLFN---WSMEENSrnehrDI--------IREKNSAVPYLLQLASLAPVLLEILC 69  
XP_008197719  233 KLRSVVGILGHLAGSHSKDIRSAILEMFQ---WSTKQESqd-sdAN--------KLQKKATVPFILQLSFLSSTLFSSIC 300 
XP_042937471  273 KFLSVCDVFTFLATQNNSELRNAMREMISndrDLLENETtt------------peQLQNLSLPFLIKIVANSPDILRFLV 340 
XP_002943024  249 KLGSVVGILGHLSSRHGQSIRQEILRMFH---ESLRPGS----------------KQQRATLPYLLQLAALSPSLLGTVC 309 
XP_003230772  245 KIASVVGILGHLASRHSESIKQELLKMFH---GSLGPTWd---------------QQQKATVPFLLQLAIMSPTLLGTIS 306 
XP_064425741  267 KIASVVGILGHLASRHSENIKQELLKMFH---ESLGPVRe---------------QQQKATVPFLLQLAVMSPMLLSIIS 328  coelacanth
XP_003970284  333 AELVDLLRPPVLLQLQTLLQGIPR---EElDNMLGLA-------------VHLISQSPSGGAKVLRF---LADTAtpasv 393 
XP_002430577  291 TDVLHTLDMKMLSNLAEFAPHWNAyfkNDtEKLEDLI-------------IHLALGCEKGGAKIISL---LLDGT----- 349 
1_pfamImport   66 CENLTQITPEVLNKLLPLYPQWKKyfdEQ-CSLLDIM-------------VQVLLNADRGIKHVLNLifqLIDCD----- 126 
3_pfamImport   70 SVIYHLVKPTIFNKLVKFGVEWAEytgSR-QALLDLI-------------VHLILSVTSNSEQLFTL---ILDGT----- 127 
XP_008197719  301 NDMKHILSVETIYKLCSFVEDWCRyfgSN-EILEDLL-------------LTLILSCDNGGIQIVNL---LLDCIsvda- 362 
XP_042937471  341 HNVYDLVTTDFIISGAKYVSQLNK------QCLLPLLpnmeytytafmrqITFYLNSD-ALAHIVEL---MLPIAfddnv 410 
XP_002943024  310 QDLVDSLKPATLSQLQQHCSTLPR---EElDNMLNLS-------------VHLACQTSAGAPRLLRF---LLDTAmpasv 370 
XP_003230772  307 VELVDSLKPAILNQLHQHFVLLPR---EDlENMVSIV-------------VHLICQTSEGAYRTLQF---LINTAmpasv 367 
XP_064425741  329 SELVDSLKQSVLNQLQQHFAVMPR---EDlENMVSLI-------------VHLICQTSNGAYRILQF---LINTAmpasv 389  coelacanth
XP_003970284  394 i--isgptPSPHEGVREGCDRLLQMLLLHLHKLVFNRtdgvevsphhsscmqPQRIIPFLEELQSHISQLCAETLRLERK 471 
XP_002430577  350 --------SYHDANIAEQSNILLELLLEDIDVQLRSY---------------KSTTIPFLESIKAEIIQVQHLLLSDNPL 406 
1_pfamImport  127 --------DPKLKILKTGAQTLFELFLAELEYSLRTN----------------RTTPPIVKALVTNLHSIKLYLLSTNIN 182 
3_pfamImport  128 --------SHPNTSVSAAAEEILE-----LELLVRGN----------------SSKVPFLDCIQKNVDNIFYMLLSDQPL 178 
XP_008197719  363 -----kpnDATTQAIKEKSLEILQNVIYRIDENVRND-----------------KRIELLTSCSHDLDEVHKNLLSVKET 420 
XP_042937471  411 frkfdnydQSFQTSMKDSALQILTEIIGMVVSLVHNQtmynvde--nallkrCATNFEILEETIQNSMA--------GGE 480 
XP_002943024  371 ---ittpgLAVHDSVREACDRIVRLLLLSLQKQVYGRpgsrg------tsevQPRAVPFLEAMRGHLPELCAEMLRLERK 441 
XP_003230772  368 ---ittpcLAVHDSVREACDRIIQLLLLNLQKLVYNRgsan-------laevPPRAVPFLDELKGHVQELCTETLRLERK 437 
XP_064425741  390 ---ittpgLAVHDGVREACDKIIQLLLLNLQKLVYNRtstn-------lidpAPRVVPFLDELKNHIKDLCIETLKLERK 459  coelacanth
XP_003970284  472 RHLWLHQLLCLLSvYGGLTVATEAFCQLLTQARNPEELALAWQLHT----------------MLSSCMVGLIPAAVTRCV 535 
XP_002430577  407 KQQTACRLFKLMG-SVNPSVIVDLSCYLLVHGTNGAHRAALLDLVQsnyscs----lwenknILALALEESLRLISGEFT 481 
1_pfamImport  183 VAQPAGRLLSCIAiRDQECLLP-YIATMLIECENSTQLETLVEILSfg-------------vNMAHFDGGLVYALVK--- 245 
3_pfamImport  179 QTTTAVTILSFIG-EQQPTMLPRCVSYVLLNSTDDEHLATIVRLAEgyk----------ssvVLSPAISLTLNATENVAN 247 
XP_008197719  421 RSQVAAQIVIFLG-HNNPSLLIRSVNFMFQNSQTVEHLSLLVKILThelvnkttwpysekggYFSVVLEQVLSRNVR--- 496 
XP_042937471  481 RSKLFIPYVHAFCiASGPVRTAEIIARYIIEAKDEKQLICLISLLTsliifa----pntsedAITNFFANRTILMLDKER 556 
XP_002943024  442 RHLWIHQLIGLLCiYSSPPCSSEALCILLTLAQSSEELGLAVQLHA----------------VLSSSVQGLAQAAVTRSV 505 
XP_003230772  438 RFLWQHQLLVLLSvHCTPSCASEALFYLLTLAKGQEELSLATQLYA----------------VLSSCMSDLLPATVKKSV 501 
XP_064425741  460 RYLWQHQLLGLLSvYCNPSCATDAIFYMLTLAKTQEELSLVAQLHA----------------VLTSSMAGLLPTTIKKCV 523  coelacanth
XP_003970284  536 AQIHTHt-----------lGPRQLKQLLLNLATAIQSQEEDTKGlqSSMATQVGTAVSGH------------LQNFSGLL 592 
XP_002430577  482 EINHQH-------------TNIDPHLLWQNISELIKFEKSRNLEd-TLSHRVVCNAVAQN------------LSPLTDLL 535 
1_pfamImport  246 -------------------TDVSLSNVWSNINTLLSLESDPPEG---ISLYGVSLAVVSH------------LDKICRSM 291 
3_pfamImport  248 IWTNLTklycthilvwflsNKRTTAFLFRSVNVFLQWESSG-----TLVSLPILNAIYDN------------LLIMSKLL 310 
XP_008197719  497 -------------------QKQDMGQTWTNLLTLLKWEKSGRVP--LLNSQIISKAILSN------------LVKFSAIF 543 
XP_042937471  557 KSSKKLtlssslsstaffeDDFYDVKWLHNLRTLNEWEKMSDDE---HVIKYIRFEMSKHygelateilrwaLDVLSSLK 633 
XP_002943024  506 AQIHAGa-----------lTDKCALQLLQNLALVVQCEE-------GSMGREVGMALSEY------------LSDFGQLL 555 
XP_003230772  502 CQIHAVg-----------lSEQNTAQLLQNMAMIIQWEGEGp----TSMGYQLGQAVSFH------------VYDFGQLL 554 
XP_064425741  524 CQIHSGs-----------iSEQHTIQLLNNLALIIQWEKQEDEGp-ASMSSQVSQIVSMH------------LYDFGQLL 579  coelacanth
XP_003970284  593 ----LHGDP-----TVSHAAVRLLSCSPLPr-----TSSPADLLLLSRAAVTHFFLVLrKQSEGTKAgrdggqgSEAVNC 658 
XP_002430577  536 s---SCYNP-----ETLNAITYVIDLLPLSsl---sTLSLQPMLRLSKNCVKYFFMCL-NEKDRWKK-------CLNCHV 596 
1_pfamImport  292 ieccHSGDM-----HSAHLLSSILSKIATKlc--mkEMSVPKVLYCVKAAVLYFFTCLfKEKDEMFK-------LKACLR 357 
3_pfamImport  311 c---KEKNI-----KVAHTIAELLKRPVLAng---yQPNIQLCRSIVKATVSYFYMCL-VKAEGIDE-------MKGLSA 371 
XP_008197719  544 -----GSET-----AHVHIISEILSQLEIPvgnnldNLPVDVVLNLTQSTVNYFFICC-NEEGTSKK-------TKGFKR 605 
XP_042937471  634 rkekTNESIsamrdSVIEAVLSLCSSIGPPs-----VLEPKYPYKLSAQFASLIVLLL-DYVGREDD-------PTGF-- 698 
XP_002943024  556 ----LHSEP-----GVCEAACILLCSCPLPt-----SIPPSQLHILIRSSSHFLFRSM-----HIRS-------SSGVSS 609 
XP_003230772  555 ----LHHNP-----AVAQAASLLLSVCPIPk-----AIRPAHLLFLIRSAVHHFFLVL-----HSQS-------PTGISY 608 
XP_064425741  580 ----LHRNI-----EVSEAASLLLSVASMPk-----AIKPALLMTIVRSAVHQFFWVL-----HRKC-------NSGISH 633  coelacanth
XP_003970284  659 SVKLLSRFAAYSAL---TLKAVLQQ-----LIEGALHKGNTDLFGGqia-------emSGAPLTSPSASTDpgvSLLDIN 723 
XP_002430577  597 ACSLLGKLCSRSSS---ARALAIRE-----LLECSLFLSASCLFGA------------NKKKNFVDSKQGY---LLMEQN 653 
1_pfamImport  358 MNKFVNTVSYRSSI---ARTAAMKY-----ILDGVLKEPFSLLFVM------------PDNRRNDYIIQPLertSLMGSF 417 
3_pfamImport  372 INAMLKKLCQSSGS---TRSYALRE-----LLESSLFRAPSVLFGS------------IPPLAQPLIEDPI---SLMMEN 428 
XP_008197719  606 INGLLRRLCTHSKV---ARVLALRE-----LLERALFRKDNVLFGA------------KNAQHDESSEK-----LLLKQN 660 
XP_042937471  699 --ALFTNACTCANEfltSQVGYVREqfiihLLDEAFAKA-SHLFGCsslnawetelqfSGGFQQTNHSIDM---SDAEEN 772 
XP_002943024  610 ASRLLLRLCRVSSA---GRKAVLNQ-----LVEGALHEGNAGLFGGn-----------RPSSTGPRLGNDTa--SLLESN 668 
XP_003230772  609 ASRLLCCLSGASLM---ASKAILQY-----LVEGALHPSKAELFGGv----------sEPPSVANDLFLEGaklSLLDIN 670 
XP_064425741  634 ATRLLFKLSGICSM---TLKAILQQ-----LVEGALRRGNARLFGGt-----------ADLFIVNESSLEDiktSLLDVN 694  coelacanth
XP_003970284  724 CRFGTAV--------NFTGSVWSVFHAGVIGKGLKVRTATKMPDPSWVIQNVQTLLAVIIQCCSpAGLNGSINGSqsqde 795 
XP_002430577  654 YQLGTTT--------ILAQRQSSVFGNGVTRHGKKEKVVVARLDEDIVKENTVYLIKAIRACCTdTTKTNSDSGN----- 720 
1_pfamImport  418 FQQEFNL--------MFGEEISIKFDKDELHPKYKTPVF----DAKSVRFNEQRLVSFLRSCYS----SDECYSF----- 476 
3_pfamImport  429 MKQGHTT--------LMGQRHSSVFHSGVIGSGKRRAVPACPIPYNDVIHNKELLLSVLEACCT-------CETS----- 488 
XP_008197719  661 KKINKTI--------PLT-KHSSVFNGGIIGRGKRKLLPPNDLPPEVVASNTSELINAIKSCCS-LPEDVDSKFS----- 725 
XP_042937471  773 DELEESLfdlarklpLYQQKPVHLAHSGIIGRGVKRLEIKNVKDGNTMRR--LVFFECLQRFCS---------------- 834 
XP_002943024  669 SHLGSAV--------DFSGSVWSVFHAGVIGAGLKPEENSKQLGEEECTENTQSLLSLLCHCCA-RKGEDGGQST----- 734 
XP_003230772  671 RRFMTAV--------NFSGSVWSVFHAGVIGRGLKPPHAPHQREPEEISHIIQNFLTLLLQCCGvGRYGQEPSQHv---- 738 
XP_064425741  695 CKFGTAV--------NFSGSIWSVFHAGIIGQGLKPSSVVLRKEKEEIVYNIQHFMNLIIQCCSgGKYHTDLNELqpn-- 764  coelacanth
XP_003970284  796 paPINAE--------AAKVVAVTLVESVCPDVANGELSWPPEEHARTTVERDIHIRRCFEAHPVLFPLLQVVAAGRPALC 867 
XP_002430577  721 --NLSLD--------AVIQVSLLMVELISPDVMYNGLPWPEEEFCKVTIERDVHIRKIFDELPLAWKLLDFIARNQPALC 790 
1_pfamImport  477 --EPTLD--------TVVSLALLVVQFVSPDVMYNGLPWPDEDFTKVTIERDVHIYHTITTKPILWTILGILAGHRPALC 546 
3_pfamImport  489 --QGTLD--------SVISIALLLVELISPDVMYNGLPWPEEDFCKVTVERDLYIRRVLDEIPLTWSLLAFIAHHRPALC 558 
XP_008197719  726 --DISLE--------SVTLVSLLLVQFVSPDVMYNGLPWPDEEFSKVTIERDLFIRRLFGNAPVLWDLLSFVAVYRPAFC 795 
XP_042937471  835 --TMGPDrnlipyqqVYKQLAIKLTDRVCKDGLAASFVWEEWEHAREVIPRYIAVSKRLTEIPLIWDIMLALTEVHPCLW 912 
XP_002943024  735 --TLDPE--------AAKTLAVTLTENACPDVTNSELAWPPEDHARTTVQRDLLIYKCFCQNPLLFQLLHLIAQGRPALC 804 
XP_003230772  739 --VVNPE--------AAKTVAVVLVETVCPDVTNSELAWPPEDHTRNTVERDIQIGRAFRDNPLLFQLLHLVAVGRPALC 808 
XP_064425741  765 mmPVNPE--------AAKTVAVVVVEYVCQDVTNSELAWPPEEHTKNTVERDIQIRKCFEENPLLFKLLQFVATGRPALC 836  coelacanth
XP_003970284  868 YCSAVLRGLLATLLAHWEASREALSTDSpw----hLQASCLLVSCMGEGQLLPPVLANVHEAFPHLSPFEVRLLLLT-VW 942 
XP_002430577  791 YCSVLLRALMATLKSQWSSTSTSDSKIV-------LAATVRLLEIMSLGQLLPPPLSSLQVAIPHLTAPEVVVLLQDcVW 863 
1_pfamImport  547 YCSVLLRAVCACLINHWGAVNHTKGKskdn--rqlLDDTVKLLNTMSLGQLLPKPLDVLGVIVPELTPQQILIVLRDcVW 624 
3_pfamImport  559 YCSVILRAVMLQIIyr-----------------dlIFTTTKILQIMALGQLLPPPFTALSDVVPHIPPHQVVLLLRDcVW 621 
XP_008197719  796 YCSVLIRALTATLIHQWKSTGEQSKSHVtenykalMNTTVKVIDVMALGQLLPPPLSSIRDVLPSLKCFEIVAILKDcIW 875 
XP_042937471  913 YCCPLLKAYLAVIMIQFENSSDQKSL-PrkqltsmLDKWFLLAR---KGQMLPQQMVYYFDLITRVSCREGFVILLD-VW 987 
XP_002943024  805 YCSVLLRGLLAVLLAYWEASRHQDSVSSsw----hLKASCELVSCMGEGQLLPPALTNMHEMFSLLAPFEVRLLLLS-VW 879 
XP_003230772  809 YCSVLLRGLMATLMAHWEASRENDTTSSpw----hLQASCDLVACMGEGHLLPAVLSNMHEIFDQLAPFEVHLLLLS-VW 883 
XP_064425741  837 YCSVVLRGLLATLMAHWEASRDNVTTSSlw----qLHASCTLIACMGEGHLLPPVLSNMHEIFHQLAPFEVNLLLLS-VW 911  coelacanth
XP_003970284  943 EYVRGNGPM--PQKFVFSPDKGQFCRDFSRD--GDVARYVAPIHSVLHKNIDRL 992 
XP_002430577  864 SYMRDNVPS--PALFTRDSRTGFMWRDPNFE--KPSSQYTETFRLILQNNIKSF 913 
1_pfamImport  625 TYTRDHIPA--PALFLRNNIGG-MWRDTTTV--AVPKPYSDSLRLTMIENISQF 673 
3_pfamImport  622 NYMRDHVPS--PALFGRDANG-VMWRDTSTS--RPPKQYTETLRHVMLDNLSSL 670 
XP_008197719  876 CYMRDHIPS--PALFVCDQNG-IHWRDPTLS--RPTEVYTNTLRIIMQRNIEAL 924 
XP_042937471  988 QYFQSVLDAevSAANMINAAFDRSLNSSIDPiqGNPTKFRESCRLVIQRNIAKL 1041
XP_002943024  880 DFIQENGPF--PQRFVFQSGRGIFTRDFSRE--GDPAKYMSIVHSVLHRNVDRL 929 
XP_003230772  884 DYMHDNSPL--PQKFSFNASTGRFFRDFSRD--ADAGKYLCVLHSVLHKNIDRL 933 
XP_064425741  912 EYMKDNSPL--PQKFTFSAEKGLFYRDFSRD--GDISKYLNVLHSVLHKNIDKL 961  coelacanth
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