Conserved Protein Domain Family
NAD_binding_11

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pfam14833: NAD_binding_11 (This model is not part of the current CDD release)
NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidised to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent and this region of the enzyme binds NAD. The NAD-binding domain of 6-phosphogluconate dehydrogenase adopts an alpha helical structure.
Statistics
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PSSM-Id: 521481
Aligned: 56 rows
Threshold Bit Score: 86.825
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q1GHN2        156 GAGQAAKICNNMILGVTMIATCEAFALADKLGLDRQKMFDVVSTSSGYSwtmNAycpAPGVGPQSPADNDYQPGFAADLM 235 Ruegeria sp. T...
jgi:Acry_3405 164 GAGQAMKALNNLVSAGGFLIGVEALLIGQRFGLDPAQMVDVLNASTGMN---NS---TQKKFRQFVLSRKFNSDFSLDLM 237
WP_012029413  166 GSGQAMKALNNLVSAGGFLIGIEALLIGQQFGIDPGLMTDVLNASTGMN---NS---TQKKFKQFVLSRRFNSGFGLDLM 239 Bradyrhizobium...
Q2KV39        174 ASAHAIKALNNYVYAAGLLAASEALAIARRMDLDPAVLADVLNVSSGRN---VA---TETKLKQFIIPETYNGGFALALM 247 Bordetella avi...
WP_012405021  169 GAGHAAKALNNYVSAAGLAATVEALHVAQRFGIEPDVMTDVLNASSGRS---NT---SENKVKQFMLSGTFASGFALQLM 242 Paraburkholder...
1_pfamImport    1 GSGHAAKALNNYVSATGLLATIEALHVAQRFGIEPEVMTEVLNTSTGRS---NT---SENKVRQFMLNGSYASGFTLQLM 74 
4_pfamImport    1 GAGHVTKLLNNLLTGIHLLAASEAVRAARAAGVDPEKLVEALNGGSGRN---SA---TLVNYPTWIFNGAFDSGFTMKLM 74 
Q89UN2        217 GAAQTMKLANNFLSATAIVATSEAVVMGVKAGLDPAVMIDVINAGSGMN---TA---SRDKFPRSVLPRTFDFGFATGLM 290 Bradyrhizobium...
Q742U1        163 GAAQTMKLANNILAANVLAATAEVVVMGVKAGLDPAVMIEVLNAGSGAT---SA---SRDKFPRAILPRSFDYGFATGLM 236 Mycobacterium ...
jgi:Veis_2971 167 GLGQTMKLANNLLSAAAVAITSEAMAMGAKAGLDPGVMLEVINAGSGRN---SA---TMEKFPKAVLTGTFNIGFAARLA 240
Q1GHN2        236 LKDLRLSQQA--AGSADADTPMGKLAEALYsQFVDKEDGKGKDFSAMLPRF 284 Ruegeria sp. TM1040
jgi:Acry_3405 238 AKDLSIALEV--GRDGGIATPFAALCREMW-ASAGAALGKGQDHTAMARFS 285
WP_012029413  240 LKDLSIALDV--ARAAGVAAPFSNLCRELS-ASAQGLLGPGQDHTALAKLs 287 Bradyrhizobium sp. ORS 278
Q2KV39        248 AKDLDTAQSLqaLTGFEA--RQLALCAGLW-KEALAQLPAGSDNTAIYRHL 295 Bordetella avium 197N
WP_012405021  243 NKDLKIARAL--AQAVGYPMVLGETCAAMW-DEAAQHSTPATDHTEMYRLL 290 Paraburkholderia phymatum
1_pfamImport   75 NKDLHIARNL--AQRLNYPMRLGMHCVDVW-DEVSRRATPMADHTEMYRLL 122
4_pfamImport   75 RKDVRLALGL--LDQQGGAAPVAREAARLW-AASEAVIGDAEDFNRIVELL 122
Q89UN2        291 VKDVRLALEE--MKQLGLSMEVADAVGRLW-ETVISAEGADSDFTAAIKPI 338 Bradyrhizobium japonicum
Q742U1        237 VKDVRLYLDE--ASALGVPAEVAETIARLW-ETTAREEGPEADFTTVIKPL 284 Mycobacterium avium subsp. paratuberculosis
jgi:Veis_2971 241 CKDVRLCLEE--SEALGVPMVVGAAVREML-VVTNAVYGKDADYTDVARLL 288
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