6LPG,6QBY


Conserved Protein Domain Family
Vasohibin

?
pfam14822: Vasohibin (This model is not part of the current CDD release)
Vasohibin
This family of proteins function as angiogenesis inhibitors in animals. Reversible detyrosination of alpha-tubulin is crucial to microtubule dynamics and functions and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. VASH1 and its homolog VASH2, when complexed with SVBP, exhibited robust and specific Tyr/Phe carboxypeptidase activity on microtubules.
Statistics
?
PSSM-Id: 521473
Aligned: 12 rows
Threshold Bit Score: 381.339
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6LPG_A         3 VPFFVNRGGLPVDEATW------------ERMWKHVAKIH-PDGEKVAQRIRGATD--LPKIPI---------------- 51  human
XP_002109112   8 VNFYINRGGFPIQQEYW------------HKLWKHTKRHHsAKGEEAENQIRGNRS--LSKVPV---------------- 57 
XP_009015876  10 TNFYVNKSGFPMDVETW------------ELMWSFACYVH-PLGVQLREDIQGRE---CPEVPI---------------- 57 
XP_002130486  20 VPFYINKNGFPVDDKTW------------EKMWRYAGKIY-PDAKSRMEKIKNNEN--LNKIPV---------------- 68 
XP_003128707  55 IPFFVNRGGLPVDEATW------------ERMWKHVAKIH-PDGEKVAQRIRGATD--LPKIPI---------------- 103
XP_004082381  29 VPFYVNRGGLPVDEETW------------ERMWRHVARIH-PNGEGLAKEIRSAAD--LPKIPI---------------- 77 
XP_003200451  64 VPFIINRGGLPVNEETW------------EQMWRHVARIH-PDGEQLARRIRGTRD--LPKIPV---------------- 112
1_pfamImport   1 VLFYVNRTGFPIEDPTW------------DRMWSHVAAVH-PEGQEMVDRIRNAAY--LPKHPV---------------- 49 
XP_031758335  70 AHFYVNKSGFPIDSQTW------------ERMWGHVAKIH-PEGKDMVDKIRNATL--LAKPSI---------------- 118
XP_003357637  47 VLFHVNKSGFPIDSHTW------------ERMWMHVAKVH-PKGGEMVGAIRNATF--LAKPSI---------------- 95 
XP_004991332  55 YDAMYRDETFPMTDASWatfvhtattrfkQATAQLAASTHtQQSKDTNDKHSASDGvlQPDVPAnvdemlklggavldvk 134
6QBY_A         9 VLFHVNKSGFPIDSHTW------------ERMWMHVAKVH-PKGGEMVGAIRNAAF--LAKPSI---------------- 57  human
6LPG_A        52 PSVPTFQPS-TPVPERLEAVQRYIRELQYNHTGTQFFEIKKSRPLTGLMDLAKEMTKEALPIKCLEAVILGIYLTNSMPT 130 human
XP_002109112  58 PIAPTITPG-MTTEERIICIQNYISDLHYNFTGLQFFEIKKSRPMSGLMEIAKDMIKESLPIKCLEAVILSIYFTCGLEG 136
XP_009015876  58 PKPPINLPSsMAVTTKLEMVQKYLESLQYNYTGMQFFCIKKDKPLCYLMEYAKDMIRASLPVKCLEAVVLAMYCTSQYAN 137
XP_002130486  69 PTVPVIPAR-LPTKQCLKLVQNYISSLQYNHTGTQLFEIRKSRPLAGLMDKAKEMIREALPIKCLEAVILAIYLTNGIQN 147
XP_003128707 104 PSVPTFQPS-TPVPERLEAVQRYIRELQYNHTGTQFFEIKKSRPLTGLMDLAKEMTKEALPIKCLEAVILGIYLTNSMPT 182
XP_004082381  78 PSVPSYQLT-TTIPQRLEAIQKYIRELQYNHTGTQFFEIKKSRPLTALMDIAKEMTREALPIKCLEAVILGIYLTNNMPG 156
XP_003200451 113 PSVPTFQPS-ISIAHRLEAIQKYIRDLQYNHTGTQFFEIKKSRPLTALMDIAKEMTRESLPIKCLEAVILGIYLTNSMPS 191
1_pfamImport  50 PSVPTFRPS-MSVPDWLVAIQNYMKALQYNHTGTQFFEIKKSRPHSRLMETAREMIRESLPIKCLEAVILGVYPTTHYLK 128
XP_031758335 119 PAVPTYKAS-MSIPEWLQAVQRYMKLLQYNHTGTQFFEIRKTRPLSGLMETAKEMTRESLPIKCLEAVILGIYLTNGQPS 197
XP_003357637  96 PQVPNYRLS-MTVPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYFTNGQPS 174
XP_004991332 135 PPQPLQQLTsGNVADALKETQRFLWRLQYNHTGMQFFPVKKYLPLTRLMELGRLICRTCLPIKCLEAVIVALYLLLPFEN 214
6QBY_A        58 PQVPNYRLS-MTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYLTNGQPS 136 human
6LPG_A       131 LERFPISFKTYFSGNYFRHIVLG--VNFAGRYGALGM-SRREDLMYKPPAFRTLSELVLDFEAAYGRCWHVLKKVKLGQS 207 human
XP_002109112 137 LDRFPISFKSCFNSHHHRHVVLG--IHYSGRYGALGL-SRRRTLMYKPLIYRSLMDLIQQYKTSYEECYHELEKVKIGLP 213
XP_009015876 138 LDRFPVSFKSQFENRVYRHVVLG--IHHMNMYGALGL-SRKPDLMYKPLVYQNLSDLLLDFVSSYNKCGHRLMKIKIGNS 214
XP_002130486 148 LDRFPIGFKSIFQGHRYYHVVLG--VFYNGKYGALGL-SRRKDLMDKPLAFKSLFDLIESYNEAYYKYTHQLKKVRIGGI 224
XP_003128707 183 LERFPISFKTYFSGNYFRHIVLG--VNFGGRYGALGM-SRREDLMYKPPAFRTLSELVLDYEAAYSRCWHVLKKVKLGQC 259
XP_004082381 157 VERFPLSFKSQYSGNHFYHIVLG--VYSGGRFGALGM-SRREDLMFKPMEFRTLTDLVQEFEGAYRGNWHTLRKVKIGQY 233
XP_003200451 192 VERFPLSFKTQFSGSHFRHIVLG--VHSGGRFGALGI-SRRQDLMYKSLQYKTLSDLLLDFQEAYRGHWHTLCRVRIGHY 268
1_pfamImport 129 TLNFTTPQTSRCSSSSIESILIShqCHHTFSHGLVGLgSKVSDLVTSCATFQVTSLIQFSFVDSYLSYQHTLKKGGSALY 208
XP_031758335 198 VERFPISFKTQFSGSFFHHVVLG--IHCNGHYGTLGM-SRRSDLMDKPLTFRTLSELIFDFEESYKNYLHTVKKVKIGLY 274
XP_003357637 175 IERFPISFKTYFSGNYFHHVVLG--IYCNGRYGSLGM-SRRAELMDKPLTFRTLSDLIFDFEDSYKKYLHTLKKVKIGLY 251
XP_004991332 215 LHRIPISFKSRFCGHTYQHIVLG--VHVNGKFGALGL-SRRQHLMYKPCRYNSLAALIREYEQRYEEVGHTLVRVRVGRP 291
6QBY_A       137 IERFPISFKTYFSGNYFHHVVLG--IYCNGRYGSLGM-SRRAELMDKPLTFRTLSDLIFDFEDSYKKYLHTVKKVKIGLY 213 human
6LPG_A       208 VSHDPHSVEQIEWKHSVLDVERLGRDDFRKELERHARDMR 247 human
XP_002109112 214 VDHSVHSCEPIKWKHVAINYKKSSTDNVRKALEKFSKQIK 253
XP_009015876 215 VPHNLLTCQSIQWGIISLNCEKMDAEKLKKQLEKSSRIIK 254
XP_002130486 225 VLHDMCSQEKIQWGILAVGYSHTSYVERQRQFGRYSRDMR 264
XP_003128707 260 VSHDPHSVEQIEWKHSVLDVEKLGREDLRKELERHARDMR 299
XP_004082381 234 VSHDPHSVEQIEWKHSIIDIDKMSKEELRKELERHTRDMR 273
XP_003200451 269 VSHDPHSVEQIEWKHSVLDVDKLTREELRKELERHTRDMR 308
1_pfamImport 209 VPHDPHVCQS-HRKHLVLNAARLGPQEMRKELEKARPRHL 247
XP_031758335 275 VPHDPHTFQPIEWKHLVINMGKMMKADIKKVLEKHARDMR 314
XP_003357637 252 VPHEPHSFQPIEWKQLVLNVSKMLRADVRKELEKYARDMR 291
XP_004991332 292 IPPSRHSTQAIPWRHLILVMKRLGEEDLRSACERYMRQLR 331
6QBY_A       214 VPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMR 253 human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap