Conserved Protein Domain Family
SOGA1-2-like_CC
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pfam14818: SOGA1-2-like_CC (This model is not part of the current CDD release)
SOGA 1/2-like, coiled-coil
This entry represents a coiled-coil region found in microtubule cross-linking factors 1 and 2 (also known as SOGA1/2), which are members of the SOGA (suppressor of glucose by autophagy) family and in the uncharacterised human protein KIAA0408. SOGA1 regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. SOGA1/2 are required for faithful chromosome segregation during mitosis. These proteins contain long coiled-coils that dimerize and holds two N-terminal domains that bind to microtubules. This region is found in association with pfam11365.
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Statistics
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PSSM-Id: 521470
Aligned: 80 rows
Threshold Bit Score: 38.7025
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KGL76327         1 MDLQKQLENTEKNWNKEKMELLERFDNERKEWECQWKIMQKKIEepdliedftlffQLYQEVKLRR 66  
16_pfamImport    1 MELRWKLQQGEKRWSRERSQLIERFHRERQDWERSLQDMQSQME------------QILKHTSEGG 54  
XP_031666456  1186 LNLHWKLQQGEKRWGRERRGLLERFDQERQEWDSNMRNMHHKME------------RLQRELNVRQ 1239
7_pfamImport     1 LDLRWKLQHGEKRWNQERVDLLEHFDRERQGWDSSMRELHRKME------------RMQRELNSRR 54  
XP_028328279  1151 MDLQWKLLHGEKRWSRERSELLERLERERQEWDGSMRELHRKME------------RMQRELNNWR 1204
XP_030630535  1195 LELRWKLQHSEKRWSRERTELLERFEHEHQEWDWRMREMHRKME------------KMQRELMYRH 1248
28_pfamImport    1 LDLRWKLQHGEKRWSRERGDLLERFDRERQEWDGSMRELQRKME------------RVRDGRTKSV 54  
39_pfamImport    1 -DLRWKLQLGERSWSREKAELLDGFDRERQEWE-----LRQAAE------------KVVRASVVFR 48  
1_pfamImport     1 -DLRRELQLGERRWSRERAELLDGFDRERQEWE-----LRQAAE------------KLFSYQFLQR 48  
XP_032808723  1196 MELRRQLHAGERGWGRERTELLQRFDHERKDWEQQLRLMRHKVH------------QLQKEKPSha 1249 sea lamprey
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