7T5P


Conserved Protein Domain Family
CANIN

?
pfam14816: CANIN (This model is not part of the current CDD release)
Coiled-coil and Nse Interacting (CANIN) domain
This domain is found at the C-terminal of the SMC5-SMC6 complex localization factor 2 (SFL2, also known as NSE6 and FAM178A)) which bridges the interaction between SMC6 and SFL1 (NSE5), being responsible for targeting the SMC5/6 complex to double-strand DNA breaks (DSBs) repair sites. It is suggested to be a regulatory element in SMC5/6 complex dynamics by locking its coiled-coiled arms together, thus being named as Coiled-coil And Nse INteracting (CANIN) domain. This domain is essential for the interaction with NSE5. It forms a U-shaped structure that seems to be structurally conserved in eukaryotes.
Statistics
?
PSSM-Id: 521468
Aligned: 12 rows
Threshold Bit Score: 504.626
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
7T5P_B         23 TGHVHPGTYTNTLERLVKEMEDTQRLDELQKQLQEDIrqgr--gikSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDA 100  human
XP_007623895   72 VSYGGSECYVNNLDYLLQEKREQALEQEWKQLLQQEH---------PNLEPSECDEDYREAVLTPEHRMLVEKFSISLQV 142 
3_pfamImport    1 STSGGSESYVNSLDYLLQEKREQALQQEREKLLLQNC---------SNLASLDPDED--EVLLTPEHRMLVERFSVSLQA 69  
XP_054100499  157 FSSGGSGSYFNNLDYLLLEKREQALEQKQERLLLQEC---------LHLNSLDTDED--EMPLTPEHRMLVEKYSVSLQT 225 
1_pfamImport    1 FTSGGSECYVNSLDYLLQEKREQALEQEREKLLLQDC---------PHLNSSDPDED--EVPLALEHRKLAERFSTSLQG 69  
2_pfamImport    1 VTSGGSGSYVNSLDYLLQEKRCVWREQEQEKLLLQDC---------LDLNSLDLDEA--DVTLTPEHRMLVEKFSVSQQV 69  
XP_005801683  664 SSSTKPGVYKNNLDQMLKEINSTKKAKEIEAQLLSACnedl--lrlAEYEAAEENQE----EIANEHQEFLQHFSLMSAA 737 
F1QB81        458 AVKTKATSYRNTLEQMLQEKEQYQRSKELERQLLESCeedl--mnlDE----DENSESKGEDISLEHREILQRFSVTSCA 531  zebrafish
4_pfamImport    1 VVSTKQVSYNNSLERLLKEKEESRGLEELERKLQDDIkrgmgvlslAE----EEESTDEDGIVVEEHKVFVQKFSVITDA 76  
XP_005048591  458 TPVISKVSYVNSLDHLLKEKEESRRLEEIEKILQEDIere---dnaSD---GENEDNASGDDLLEEHRAFIKRCSVVSYV 531 
ELV11543      159 LTSGGSGSYVNSLDYLLQEKREQALEQEREELLLQDC---------LSLSSLDLHED--EAPLSPEHRMLVERFSVSLQV 227 
Q8IX21        657 TGHVHPGTYTNTLERLVKEMEDTQRLDELQKQLQEDIrqgr--gikSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDA 734  human
7T5P_B        101 IPDHHPGEEIFnflnsgkIFNQYTLD--LRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQ-CPVPVLKWLF 177  human
XP_007623895  143 ISPVHPGETVF-------LPRRQPLPciLDSSSLKPHSQLEELFLRSPLPQQLSFLHKGLLSNLYLHASdYPRPLLQWLF 215 
3_pfamImport   70 IPLVHPGKIVF-------LPRHHPLPciLDSSHLKPRNSLEELFLSSPLAQQLSFLHNGLLSTLYLHVPdCPVPLLQWLF 142 
XP_054100499  226 IPPVHPGETVF-------LARRHPLPciLDSSHLKPRSHLEELFLSSSPAQQLSFLRSGLLSTLYLHMPdCPVPLLQWLF 298 
1_pfamImport   70 IPAGHPGETVF-------VPMHHPLPhmLDHSRLKPRSHLEELFLSSPPAQQLSFLRSGLLSGLYLHVGdRPEALLRWLF 142 
2_pfamImport   70 IPQVHPGEAVF-------LPTCHPQPhvLDCSQLKPCSYLEGLFLSSPPAQQLSFLRRGLLSNLYLHRPdCPVPLLQWLF 142 
XP_005801683  738 IREIPPGEIVFnlerfgqVFHQDSLQ--LRQCHVSPQGASQKTLIWSSPAQLRLHLNVGLFEEAYCNSP-CPAQVTCFLF 814 
F1QB81        532 IRDIHPGEEIFtpakfgqLFNHQTLD--LRKISVTPHNRSQQILLQARSEHVLSLISAGLLRKAYFSFP-CQPEVTRWLF 608  zebrafish
4_pfamImport   77 IPDLHPGEEIFelsssgkLFTVTSLD--LKNSEVQPQNALEKLILSSGREQQIVLVTQGFLSQAYKLAP-CPSHVFKWLF 153 
XP_005048591  532 IPDKHPGEDLFdlsaagnIFTQHDLD--LRNFHFIPQNRVEYLLLNSGLTQQLFLVVNGVLSSAYCATL-CPIPILKWLF 608 
ELV11543      228 IPSVHPGETVF-------LPRRHPLPciLDCSNLKPHSRLEELFLSASPSQQLSFLRSGLLSNLYLHTShCPVPLLQWLF 300 
Q8IX21        735 IPDHHPGEEIFnflnsgkIFNQYTLD--LRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQ-CPVPVLKWLF 811  human
7T5P_B        178 RMMSVHTDciVSVQILSTLMEITIRN----DTFSDSPVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQPdfNEDYLVSE 253  human
XP_007623895  216 KLLTWPPE--TSSRAFSLLWDLSIDGl---FRQPDEDMRLWCPSLQEVKEVFRSLGAYNPALYPQGPFRH--STRVLESE 288 
3_pfamImport  143 QLLTWPPE--TSVVAFSLLWDLSVDGl---FCKSDRDMHLWCPSLQEIMEAFHSLGAHDPALCPQGLCQH--SSRELSSE 215 
XP_054100499  299 QLLTWPPE--TSLGAFGLLWDLSVDEl---FLQSDEDMHLWCPSLQEIREAFHSLGAYSPALYPLGPFWH--SGRMLPGE 371 
1_pfamImport  143 QLLTWPPE--TSLGAFGLLWDLSVDGl---IRQSDEDTYLWCPSLQEVTAAFHSLGARSPALHPLGPFQH------SGSK 211 
2_pfamImport  143 QLLTWPPE--TSSEAFGLLWDLSTDRl---FHPPEEDTHMWCPTLQEIMEVFQSLGAQSPALYPAGPHPH--GGRVLKSK 215 
XP_005801683  815 KMMSVHSEriISNKILRALCDIACSAayqiVNNDNQKFEVWVPSLADVTLVFMNMGAAFVTLFPFESLQPsfTEGDLLED 894 
F1QB81        609 QMTSVHPNpiISSRIMQSLHTIALSAaqhiVEHKSQSFTVWVPSIRDITQVFLNMGASFISLFPLDVLQPpfTEGDLLED 688  zebrafish
4_pfamImport  154 QMMAVHSDflVSGQILKTLMDITLHTahqrVETGDPRWEIWIPSVKEVSVVFVNMGIRFKNLLPVTHPRLyfNEEEIMGQ 233 
XP_005048591  609 QMMSIHPDhcVSTQILSRLMELTLKN----SSINDQQFKPWIPSIADISAVFVNMGIEFRSLFPLQHFQPpfNEHDILSQ 684 
ELV11543      301 QLLTWPPE--TSLGAFGLLWDLSVDRl---FLQSDEDMHLWCPSLQEVTEAFYSLGAYSPSLYPLGPFQH--SGRVLNSE 373 
Q8IX21        812 RMMSVHTDciVSVQILSTLMEITIRN----DTFSDSPVWPWIPSLSDVAAVFFNMGIDFRSLFPLENLQPdfNEDYLVSE 887  human
7T5P_B        254 TQTTSRGKESEdss-ykpIFSTLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLI 332  human
XP_007623895  289 ASLGWWEPHNS-------TQEVALDIKLSYIYRFLILCFLVQPRSYTDANILGLMELLCRAGLDVGLRLLPKTDLQQLLL 361 
3_pfamImport  216 ASLSGNEQQDT-------PQEVALDISLSYIYKFLTLCAVAQPGAYTDGSLMDLIELLCHTGLDVGLRLLPKADLQQLLL 288 
XP_054100499  372 AGLSENKHQDA-------PQEVTLDISLSHIYKFLSLCAQAQPGAYTDENLMDLIELLCRTGLDVGLCLLPKTDLQQLLF 444 
1_pfamImport  212 ANLSQCEQQDT-------PGETALDISLSHICKFLMLCALAQPGAYPDGSLLGLIELICQAGLDVGLRLLPKTDLQQLLL 284 
2_pfamImport  216 VSLSWDEQQTA-------PQEMALDVSLSYICKFLTLCALAQPVAYTDDSLLGLMELLCQAGLDVGLRLLPKTDLQQLLL 288 
XP_005801683  895 VYLKSESPTNNs------EEISFPEHNCTNILKYLSYCMGLCPHAYSNDELLLLLTVVGRISLDTRLILQSNVAVSCLLY 968 
F1QB81        689 FKPEENSQDSAise--ikDDATLPVHNLESVLSYLSLCTALCPKAYTDEELLLLLAVVCRIGLETHFQLLPTGSFSLLLQ 766  zebrafish
4_pfamImport  234 L-AAVQGEQMRtkvsqegVFSHLPETNIINVVKFLVLCTSISPDAYNDEDLLLLVLLLARVSLEKTLQLTPLIDFQCLLE 312 
XP_005048591  685 VQETVSQKQPRgdv-aspAFPSLLENNLINVIKFLVFCTSVIQDGYTDQEIWLLLVLLFKISLEKQLKQHFVVDFQCLFV 763 
ELV11543      374 ASLGWDGQREA-------PQQVALGISLNYIYKFLTLCAFARPGAYTDGNLLGLIELLCRAGLDVGLRLLPKTDLQQLLL 446 
Q8IX21        888 TQTTSRGKESEdss-ykpIFSTLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLI 966  human
7T5P_B        333 NLMKNIRDWNTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKHE 397  human
XP_007623895  362 LLLENIQEWPGKLQALCCTLSWVSDHHHNLLALVQFFLDVTPRARQLRSQLSLTVIARMLGQQEA 426 
3_pfamImport  289 LLLENIQEWPEKLQQLCSTLSRVSDHHHNLLALVQFFLDVTSRSRQLRSQLSLVVIARMLGQQET 353 
XP_054100499  445 LLLENIQEWPGKLQELCCVLSWVSDHHHNLLALVQFFPDVTSRSRQLRSQLSLVVIARMLGQQET 509 
1_pfamImport  285 LLLENIQEWPGKLRPLCCALSQVSDHHHNLLALVQLFPDVTSRSRQLRSQLSLVVIARMLDQQET 349 
2_pfamImport  289 LLLENVQEWPRKLRQLCCALSSVSDHHHNLLALVQLFPDLTARSRQLRSQLSLVVIAQMLGQQET 353 
XP_005801683  969 TIINNISDWSSVLPRVCKALTDLTDDHHNMCLLVQLLPD-SKCGKELRRHLSMCFISKLLDGNCT 1032
F1QB81        767 NVLKNITDWDVQISKACQILTDLSEDHHNLRRIVSILPE-SSRGKLLKRHLSVSIISKLLNHTCT 830  zebrafish
4_pfamImport  313 QILENIQAWDTKMPELCMTLSDLSAHHHNLLRVVQLLPSFHTRGRQLRGHLSMMIISKLLDERCT 377 
XP_005048591  764 KLLMSIKDWDTKMPELCLAVSELSNNHHNLLWLVQLVPSLTARGREVKRRLSLVIIAKLLHKRHV 828 
ELV11543      447 QLLENIQEWPEKLPKLCRALSWVSDHHHNLLALVQFFLDVTTRSRQLRSQLSLEVIARMLGQQES 511 
Q8IX21        967 NLMKNIRDWNTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKHE 1031 human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap