Conserved Protein Domain Family
AP3B1_C
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pfam14796: AP3B1_C (This model is not part of the current CDD release)
Clathrin-adaptor complex-3 beta-1 subunit C-terminal
This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.
Links
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Statistics
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PSSM-Id: 521452
Aligned: 28 rows
Threshold Bit Score: 144.73
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004349174   878 SNAGPSLLDLSd-DFAAsPLPTASPFLlhgaPlAAYAPAASTPAAavsa---tsssFAPVyLYAP---PTSKHTLLN-KV 949 
XP_046436873   792 KSNLDLLLDLDvsD----SAPVMASVSgiplG-TLASTPIt--------------dSSVQ-PVSAayiSTRPTELVSsIS 851 
XP_002075331   860 KSNLDLLLDLD--DIPP-IGPVMTPSL----G-GFLTPGTPAVTQtqas----patGGLE-LVGPsyiEFKHKQLLN-KV 925 
XP_002037010   868 KSNLDLLLDLD--DIPP-IGPVMTPSL----G-GFLTPGTPMMAGqaaplqpqharNHVE-LVGPshiEFKHKELLN-KV 937 
XP_001991399   917 KSNLDLLLDLD--DIPP-IGPVMTPSL----G-GFLTPGTPMMPGqaalq-pqqahNRIE-LVGPshtDFKHKELLN-KV 985 
XP_001851063   820 KHDLDLLLDLN--DIPP-VGPIMTPSL----G-GFLTPMVGTHPEnas------snDVVD-LVGPsfiPTKSSELLN-KI 883 
XP_001688349   885 KSNLDLLLDLD--DIPP-IGPVMTPSL----G-GFLTPMAATNTAga--------gTGIE-LVGPsfiPIKKHELLN-KV 946 
11_pfamImport    1 TSNLDLLLDLD--DVVP-NLPVMTPSY----G-GFLTPLTATPTTa--------------nVVGPsyiPVKAQEVLN-KI 57  
XP_002427262   787 KTNLDLLLELN--DALPsTAPVLTPSL----G-GFTNNASSVSHTk---------vQSIE-TVGPsyvSYKGKELVN-KL 848 
XP_002435122   764 RKNVDLLLDLD--DIATvSSAPLQPFSaltmT-SV--PIAAPKPSgpk----------favVPVPayvSHERKELLN-KL 827 

XP_004349174   950 TGKGLFVEYRFTRRASVYSQTMTGIQLLFENTSGAAI-KGISCASK-SVDGA-VEIAPFAEIAE-LGAHATSEAVIGINF 1025
XP_046436873   852 SGCGLQILYRYTRSINLYSPSMVTIELTLVNTGNEEL-TEVKITNK-NMPVG-ISMHEFTTLAS-LPVGATRLVTVGIDF 927 
XP_002075331   926 SGHGLQLAYRFTRAPHLYSSSMCSIELQFQNCGPHEI-TNIHLGQR-TLPAG-MQLNEFSPVAQ-LQPQQMASGVLGIDF 1001
XP_002037010   938 SGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRDEKEI-TAIRLGQT-TLPAG-MQLNEFAPITV-LQPQQTASGVLGVDF 1013
XP_001991399   986 SGHGLQLSYRFTRAPHLYSAAMCSIELQFQNRSDQEL-DNIRMGQQ-QLPSG-MQLSEFAPIVQ-LLPQQMASGILGVDF 1061
XP_001851063   884 NGYGLGIAFRFTRAPHLYSAKMISIELTFTNHGNVEL-TDIQLGQK-GLQAG-MTLNEFPPIEI-LNPKQSWTGILGLDF 959 
XP_001688349   947 NGFGLGIEYRFVRSPHLYSSRMVSVELTFTNHGNVEL-VDIEMGKKgNLPAG-MAVNDFAPIGR-LNPGQSVTGMLGVDF 1023
11_pfamImport   58 TGQGLSVEARFTRQPHLYSAKMTSVELKFINNSPTDIfEDIRVSSK-ILPSG-IMLHDFAPLSR-LLPQQYSIGNIGVEW 134 
XP_002427262   849 NGGGLSVEYRYTRSPHLFSYKMISIELTFINHGPDDV-TEIKIDSK-DSNQG-IIIHGFTPISC-LKVNSRQSELIGVDI 924 
XP_002435122   828 SGSGLSVSYRFSRSPNIFSPRMTSIELVLTNHGDKEL-QELYVPDR---KSGqVEIKGFPRSGTpLGPGSSIVGTVGIDF 903 

XP_004349174  1026 NDKSQ 1030
XP_046436873   928 GDSTQ 932 
XP_002075331  1002 NDSTH 1006
XP_002037010  1014 NDSTH 1018
XP_001991399  1062 NDTTH 1066
XP_001851063   960 NDSTQ 964 
XP_001688349  1024 NDSTQ 1028
11_pfamImport  135 NDSTQ 139 
XP_002427262   925 NDSTH 929 
XP_002435122   904 NESTQ 908
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