Conserved Protein Domain Family
NEPRO_N
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pfam14780: NEPRO_N (This model is not part of the current CDD release)
Nucleolus and neural progenitor protein, N-terminal
This domain is found at the N-terminal of nucleolus and neural progenitor protein (NEPRO) which may play a role in cortex development as part of the Notch signalling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. NEPRO may also play a role in preimplentation embryo development. NEPRO interacts with multiple protein subunits of RMRP and is implicated in Anauxetic dysplasia 3. NEPRO is likely the human orthologue of RMP1 subunit from yeast and they share a four-helix bundle domain structure.
Links
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Statistics
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PSSM-Id: 521438
Aligned: 24 rows
Threshold Bit Score: 191.669
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002933056          6 WNRLHIPRPAIQSLvtvpaSAETEeYIKAVVEKCLSVKQSLMSKV----LETEKSALYSILYVYHHQLGYHKPYLALKQV 81 
XP_003425944          5 WNQINLQRPPYRSW-----DVSVTeFDSK--RFIDSIDKILSDFKtfqvLHAEAALLSRLIYRMKSKFRSDKGLKHMEKV 77 
XP_001956285          8 WNDFELKKPPLVTI-----EVENTgFAKNVFVAINKFLQQMGGQD----FDETAALIGRLMTRRKNSFRNMPGFRAICKL 78 
XP_002029931          7 WNDFKLKQPPLVTL-----LVKDTsFAKNVFVVINRFLQQLSEPDak-dFEETAALIGRLMARRKNSFRNMPGFRSVCKL 80 
WGS:AAQB:GK10934-PB  11 WNDFELKKPPLVNI-----QVTDTkFAKHIFVAINRYLQQLTAPDat-eFAETAAMIGRLMARRKNSFHNMPGFRDLCKL 84 
XP_002007604          7 WNEFELKKPPLVTL-----QVKETgFAKNVYMAINRYLQQQSRPDfv-eFNNTAALIGRLMARRKNSFRGMPGFRAVCKL 80 
XP_001983692          7 WNDFELKKPPLVTL-----HVSETrFAKDVFVVINRYLQQLSSPNgq-eFNQTAALIGRLMARRKNSFRSMPGFRAVCKL 80 
XP_038119314          4 WNQKDLVPPALATY-----MCKSKsCKSEIRALVSTLSEAIQYFEslgsFDEAAAYLSRFATRWNNRFYNMHGFRLLKRL 78 
XP_049530918          4 WNRLDLVPPALMNE-----ECTTKhIKDEIRALTNTSGKMLIYFVslqkFEKAAAYLSRFCVRYKARQRNMHGFQIMRRL 78 
XP_032514880          5 WNDRSILPPPINTS-----KCSYDiDLIGLKHACTSIIHILSKQSp---LHKESAIFSRFVYKFDKKFRNDIGYKNFKKV 76 

XP_002933056         82 EQCLKRLAAMGLEVTIQEMLDLCPryfgKNVLTAEKHCCLPSQPIIEVVSIKILGACKLFLRLMDCCEKAFHLCLQHIYL 161
XP_003425944         78 NRALLNYLNMAMEREYELLKEYIE----IN---N-GIISLPPRQTLEYVLVRTQGFAKLMCRVESTALIAGNFLKSRLCI 149
XP_001956285         79 NSALCRLLRLDLCRDLEQFRGSLPdvyvED-----TEGALPTKSSFEFILVRLLAFYYLHKRIAECCLSAASYFTKLLRS 153
XP_002029931         81 NAALCRLLRLDLARDLENFRGALPdvcdED-----LGGAMPTRSSFEFILVRLLGFYHLHERIRECCLSAAAYFTQLLRN 155
WGS:AAQB:GK10934-PB  85 NASLCRLLRLDLPRELEHFRSALP-----DICDDELAGALPTRSSFEYILVRLLAYYHLQERIRECCLGAANYFAQMLRN 159
XP_002007604         81 NAALCRLLRLDLPRDLEHFRGALPdacdAE-----LSGDMPTRNSLQFVLVRLLAFYSLHERIRDCCQAAIKYFGQMIRS 155
XP_001983692         81 NATLCRLLRLDLPRELEHFRGALPdacdDE-----VSGEMPTRNSLEFILVRLIAFHRLHERIHDCCVAAAKYFGQMLRN 155
XP_038119314         79 NQALVRFRSVDIVRILTNVFSTLP----DGNYLE-PVVELPTRGNVDYLLVRLQGVAKLFCRIVVLAKEAARYYVRFMSS 153
XP_049530918         79 NQTLLRIKKLDIVREITDFHSFLP----ESSYIE-KVMRLPVRSNLEHLLIRLQGLAKLLLRVVLLTKDAACYQLKQINR 153
XP_032514880         77 NTALRRYLVVGLLKDVQKFLNVLP-------SEDESSPYFPTKQMLEYVLVRLITFSKIMFRITVCSKKASIFYLNRIRR 149

XP_002933056        162 EEFIVANVVLLGLLSRLWVLHRGILKKLISLYGAQY 197
XP_003425944        150 GQSWTVAMIAYAVISRIWILSRHVIKKSCNWYNSIF 185
XP_001956285        154 NFFMDFTTLLIAAIAKIKKLSADQATQSAQLYNKLR 189
XP_002029931        156 NFFMEFTTLLIAAIAKLSKLSSLQAGKSATLYNKLR 191
WGS:AAQB:GK10934-PB 160 NFFMEFLTLLMAAVAKINKLSSLQSNKCVTLYNKLR 195
XP_002007604        156 NFFMEFLTLLIAAVAKINKLSLVQANNCATLYNKLQ 191
XP_001983692        156 NFFMEILTLLIAAIAKINKLSQLQANSCATLYDKLL 191
XP_038119314        154 GYFFNLSSMFLCLQAEIWFKSREICRQTVQFYNKLV 189
XP_049530918        154 VFLFYHSSIFLALMGELWLLARNISRRVNQYYDELY 189
XP_032514880        150 GESHWMCLMPYALLSRVWSLSLVLLQHSSKWYSRLH 185
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